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Suppression Subtractive Hybridization법에 의한 교모세포종에서 특이적으로 발현하는 유전자의 동정 및 기능 연구
유나미 ( Na Mi Yu ),안정용 ( Jung Yong Ahn ),김계성 ( Kye Seong Kim ),김창현 ( Chang Hyun Kim ),김태규 ( Tai Gyu Kim ),최은진 ( Eun Jin Choi ),김진경 ( Jin Kyeoung Kim ) 대한뇌종양학회 2004 대한뇌종양학회지 Vol.3 No.2
A variety of genetic alterations in human glioblastomas comprises signal transduction and cell cycle arrest control of cellular processes. Subtractive hybridization is potentially a faster method for identifying differentially expressed genes associated with a particular disease state. Using the technique of subtraction, we isolated a novel gene that is overexpressed in glioblastoma as compared to normal brain tissue. Glioblastoma was used as tester and brain normal was used as driver. We identified 23 novel genes by BLAST of the digested 130 clones. In this study, we selected that this 571 bp cDNA of “clone 25” was not homologous to any of the known genes in the Genbank database. The expressions of mRNA of “clone 25” of brain tumors were significantly higher than normal brain tissue. “Clone 25” is clearly more frequently and more strongly expressed in several carcinoma cell lines compared to corresponding normal tissues of lung, colon, and prostate. To test the time course for G0-phase arrest, serum stimulation and expression at various times for RT-PCR was performed. We confirmed the mRNA expression of “clone25” was up-regulation for 0.5, 1, 2, and 4hr of WI-38 cell differentiation. The novel gene, “clone 25” was upregulated in glioblastoma tissue and several cancer cell lines. This gene is time dependent activation during time course of serum stimulation. Expression and activation of “clone 25” may be important and specific development roles of glioblastoma.
정상미 ( Sang-mi Jung ),김창현 ( Chang-hyeon Kim ),노현우 ( Hyeon-woo Noh ),최진우 ( Jin-woo Choi ),정유진 ( Yu-jin Jung ),문의성 ( Eui-seong Moon ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2
최근 보안적 이슈에 따른 피해가 지속적으로 늘어남에 따라 사람들이 보안에 관심이 많아 지기 시작했다. 모의해킹 분야의 경우 기존에 문제 풀이 웹 사이트들이 존재하지만 회원 가입 단계부터 입문자들이 시작하기에는 높은 진입장벽이 존재한다. 본 연구에서는 방 탈출 게임의 컨셉을 모의해킹에 적용하여 모의해킹 문제를 게임을 푸는 방식으로 접근하여 입문자들도 쉽게 모의해킹 분야를 시작할 수 있도록 하였다. 웹 서버는 오픈소스 웹 방화벽인 ModSecurity[1]와 Spring Security 로 서버 보안을 강화하였다.