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김종태,박현준,Kim, Jong-Tae,Park, Hyeon-Jun 한국광학회 2021 한국광학회지 Vol.32 No.1
In this paper, an aircraft warning light's optical system was designed using an LED light-source module and a collimating Fresnel lens. As for the optical system, a collimator Fresnel lens was designed for each module to satisfy a vertical-elevation center luminous intensity of 20,000 cd and the divergence-angle luminous-intensity standard conditions of the Ministry of Land for Infrastructure and Transport for aircraft warning lights. In addition, the optical system was optimized by adjusting the position and tilt of the LED light-source module and Fresnel lens. By analyzing and comparing the light-distribution characteristics of the optical system, an aircraft-warning-light optical system with optimal performance was obtained. 본 논문에서는 LED 광원 모듈과 시준용 프레넬 렌즈를 이용하여 항공기 장애등 광학 시스템을 설계하였다. 설계된 광학계는 국토 교통부 항공기 경고등의 수직 양각 중심 광도 20,000 cd와 발산각 광도 규격 조건을 만족시키기 위해 프레넬 렌즈를 모듈별로 설계하였다. 또한 LED 광원 모듈과 프레넬 렌즈의 위치와 기울기를 조정하여 광학 시스템을 최적화하였으며, 이렇게 설계된 광학계의 배광 특성을 분석하고 비교하여 최적의 성능을 가진 항공기 경고등 광학계를 설계하였다.
기초 : 악성신경교종의 세포고사체로 감작시킨 수지상세포에 의해 유도된 종양특이적 T 림프구의 HLA Type에 따른 세포독성
박익성 ( Ik Seong Park ),정동섭 ( Dong Sup Chung ),한영민 ( Young Min Han ),장경술 ( Kyung Sool Jang ),김종태 ( Jong Tae Kim ),박영섭 ( Young Sup Park ) 대한뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2
Objective:The purpose of this study is to determine whether human dendritic cells(DCs) pulsed with glioma apoptotic bodies(GABs) can induce tumor-specific T lymphocytes having cytotoxicities to allogeneic glioma cells matched or mismatched at class I human leukocyte antigen(HLA) loci. Methods:DCs were generated from peripheral blood mononuclear cells(PBMCs) of HLA-A2 positive healthy donors cultured in the presence of granulocyte macrophage-colony stimulating factor and interleukin(IL)-4. GABs from HLAA2 positive T98G glioblastoma cells following actinomycin D treatment were pulsed to DCs. CD8+ T lymphocytes isolated from PBMCs of the same donors were cultured in media containing IL-2 and were stimulated by GAB-pulsed DCs three times at weekly interval. Then cytolytic activities of these cytotoxic CD8+ T cells against HLA-A2 positive T98G and U87 glioblastoma cells, and HLA-A2 negative A172 glioblastoma cells were determined by a standard 4hr [51Cr]-release assay. Results:The average percentages of T98G , U87 and A172 cell lysis were 43.7%, 45.6% and 5.1% compared with 3.6% of controls at an effector to target cell ratio of 40:1 respectively. The cytotoxic T lymphocytes(CTLs) primed with HLAA2 positive T98G GAB-pulsed DCs had cytotoxicity to HLA-A2 positive T98G and U87 glioma cells but not to HLAA2 negative A172 cells(p<0.01). Conclusion:This study showed that tumor-specific CTLs generated by stimulations with GAB-pulsed DCs had cytotoxicity to the glioma cells in a HLA-restricted manner. This result suggests the feasibility of the use of HLA-matched allogeneic glioma cells as a source of antigens for patients not eligible for surgery in the DC-based immunotherapy.
암반 불연속면의 거칠기 특성 -조,중,세립질 화강암을 중심으로-
김종태 ( Jong Tae Kim ),정교철 ( Gyo Cheol Jeong ),김만일 ( Man Il Kim ),송재용 ( Jae Yong Song ),박창근 ( Chang Kun Park ) 대한지질공학회 2004 지질공학 Vol.14 No.2
이 연구는 지하수유동에 영향을 주는 조·중·세립질 화강암 불연속면 거칠기의 특성을 비교한 것이다. 공초점 레이저현미경으로 관찰된 거칠기 데이터는 스펙트럼 분석과 고속푸리에변환에 의해 해석되었다. 또한 노이지가 제거된 거칠기 데이터에 대하여 거칠기 특성을 정량화하기 위하여 프랙탈 해석에 적용해 보았다. 이를 위해 조·중·세립질 화강암 코어를 대상으로 브라질리안 시험으로 인공 단열을 발생시켰다. 측정은 전체 12개의 공시체에서 36개의 조사선에서 실시되었다. 공초점 레이저 현미경을 사용하여 연속적인 거칠기를 이산 데이터로 표현할 수 있으며, 이렇게 하여 얻어진 이산데이터를 바탕으로 고속 푸리에 변환을 실시한 결과 제2 고조파 성분이 가장 큰 값을 보이고 있다. 또한 스펙트럼 에너지 분포는 조립질 공시체에서 0.9853, 중립질 공시체에서 1.0792, 세립질 공시체에서 0.6794의 평균값을 보이고 있으며, 이는 프랙탈 해석에서와 마찬가지로 거칠기가 클수록 저주파수 영역대에서 고조파의 에너지 분포가 높게 나타남을 알 수 있다. Purpose of this study is to quantitatively characterize the fracture roughness which was measured with a confocal laser scanning microscope. The roughness discrete data measured by confocal laser microscope were analyzed by spectral analysis and fast Fourier transform (FFT).The roughness data by used noise reduction filter were applied for fractal analysis to describe roughness features quantitatively. Artificial fractures created by Brazilian test on granites were used to measure fracture roughness under the confocal laser scanning microscope. Measurements were performed along three scan lines on each fracture surface. 36 scan lines were determined on 12 specimens in total. Features of roughness showed that coarse and medium grained granites tend to more rough features than those of fine grained granites. Continuous analog data of roughness is possible to described as discrete data of measure roughness with a fixed interval under the confocal laser microscope. Results of FFT with the measured data showed the highest values on the second harmonics. Distribution of average amplitude of second harmonics was observed 0.9853 in coarse grained granite, 1.0792 in medium grained granite and 0.6794 in fine grained granite. This indicates that the larger roughness has the higher energy of harmonics as the result of fractal analysis in low frequency zone.