울산 지역 고혈압 노인의 비만 지표 및 혈중 총항산화도

김정희,김미정,곽호경,Kim Jung-Hee,Kim Mi-Joung,Kwak Ho-Kyung 대한지역사회영양학회 2006 대한지역사회영양학회지 Vol.11 No.2

The role of free radicals in the progression of many diseases and aging has been given a great attention and total antioxidant status (TAS) has shown to be reduced with aging. The incidence of hypertension has shown to be relatively high in the aged population, and it is known to be associated with increased obesity and oxidative stress. The aim of this study was to examine the obesity indices and the total antioxidant status in hypertensive elderly (64y<age<80y) and to compare with elderly controls. Obesity indices such as Body Mass Index (BMI), Percent Ideal Body Weight (PIBW), Waist-Hip Ratio (WHR) and weight were significantly higher in the hypertensive elderly than controls (p<0.05). TAS was significantly higher (p=0.001) in the hypertensive elderly than controls, and was significantly positively correlated with weight, BMI, PIBW, systolic blood pressure, diastolic blood pressure (p<0.05). Uric acid tended to be higher in the hypertensive elderly than controls and significantly correlated with TAS and BMI, while plasma concentrations of $\alpha$-tocopherol, $\beta$-carotene and ascorbic acid did not show their significant correlations with TAS. These results showed that the hypertensive elderly are prone to be obese and to have increased TAS. Due to unknown factors affecting TAS values, measurement of plasma TAS as a sole indicator of total antioxidant capacity is limited to fully understanding changes in the body's free radical trapping power. However, the results from the current study may suggest that hypertension and/or obesity might increase oxidative stress, followed by increased the body's total antioxidant defense system.

교모면적과 저작근 활성도와의 관계에 대한 연구

김정희,윤창근,Kim, Joung-Hee,Yoon, Chang-Keun 대한치과보철학회 1987 대한치과보철학회지 Vol.25 No.1

The purpose of this study was to obtain basic data needed to clinical diagnosis and treatment by investigating the occlusal wear facets and those related factors. Sixty-six subjects, ranging from 24 to 26 years of age without symptoms of stomatognatic system, were selected from dental students in Chosun University. The area of occlusal wear facets was measured and twenty subjects were selected, and divided into two groups (Group I and Group II). The Group I had small facet areas, and the Group II had large facet areas. These two groups were investigated into right and left side wear facet areas, vertical overlaps, occlusion types of working side, masticatory muscle activities, and asymmetry of right and left side masticatory muscle function. The results were as follows: 1. The average wear facet areas of all subjects was $22.84{\pm}88.95mm^2$, and Group I and Group II were $96.12{\pm}32.00mm^2$ and $372.94{\pm}65.63mm^2$ respectively. 2. The right and left wear facet areas of Group I were $46.72{\pm}14.36mm^2$ and $49.40{\pm}21.46mm^2$ respectively. The right and left wear facet areas of Group II were $175.27{\pm}45.75mm^2$ and $185.69{\pm}45.37mm^2$ repsectively. 3. The vertical overlap of Group I and Group II was $3.88{\pm}0.81mm$ and $2.88{\pm}1.14mm $ respectively. 4. Most of the Group I had Canine protection occlusion (80%), and most of the Group II had Group function occlusion (80%). 5. The masticatory muscle activities at rest position, maximum bite, habitual chewing, right and left unilateral chewing were greater in Group II than in Group I, especially in the masseter muscle of working side at right and left unilateral chewing. (P<0.01). 6. The asymmetry of right and left wear facets and masticatory muscle activities were greater in Group II than in Group I. (P<0.01).

Overdenture 하에서 하악응력 및 의치의 변위에 관한 유한요소법적 분석

김정희,정재헌,조규종,Kim, Joung-Hee,Chung, Chae-Heon,Cho, Kyu-Zong 대한치과보철학회 1990 대한치과보철학회지 Vol.28 No.1

The purpose of this study was to analyze the displacement and the magnitude and the mode of distribution of the stresses in the lower overdenture, the mucous membrane, the abutment tooth and the mandibular supporting bone when various denture base materials, such as acrylic resin and 0.5mm metal base, and various denture base designs were subjected to different loading schemes. For this study, the two-dimensional finite element method was used. Mandibular arch models, with only canine remaining, were fabricated. In the first denture base design, a space, approximately 1mm thick, was prepared between the denture and the dome abutment. In the second denture base design, contact between the denture and the dome abutment was eliminated except the contact of the occlusal third of the abutment. In order to represent the same physiological condition as the fixed areas of the mandible under loading schemes, the eight nodes which lie at the mandibular angle region, the coronoid process and the mandibular condyle were assumed to be fixed. Each model was loaded with a magnitude of 10 kgs on the first molar region(P1) and 7 kgs on the central incisal region (P2) in a vertical direction. Then the force of 10 kgs was applied distributively from the first premolar to the second molar of each model in a vertical direction(P3). The results were as follows. : 1. When the testing vertical loads were given to the selected points of the overdenture, the overdenture showed the rotatory phenomenon, as well as sinking and the displacements of alveolar ridge, abutment and lower border of mandible under the metal base overdenture were less than those under the acrylic resin overdenture. 2. The maximum principal stresses(the maximum tensile stresses) being considered, high tensile stresses occured at the buccal shelf area, the posterior region of the ridge crest and the anterior border region of the mandibular ramus. 3. The minimum principal stresses(the maximum compressive stresses) being considered, high compressive stresses occured at the inferior and posterior border region of the mandible, the mandibular angle and the posterior border region of the mandibular ramus. 4. The vertical load on the central incisal region(P2) produced higher equivalent stress in the mandible than that on any other region(P1, P3) because of the long lever arm distance from the fixed points to the loading point. 5. Higher equivalent stresses were distributed throughout the metal base overdenture than the resin base overdenture under the same loading condition. 6. The case of occlusal third contact of the abutment to the denture produced higher equivalent stresses in the abutment, the mandibular area around the abutment and the overdenture than the case of a 1mm space between the denture and the abutment. 7. Without regard to overdenture base materials and designs, the amounts and distribution patterns of equivalent stresses under the same loading condition were similar in the mucous membrane.

포도전정가지 추출물이 UVB에 유도된 HR-1 mice의 피부손상에 대한 광보호 효과

김정희(Joung-Hee Kim),김종국(Jong Guk Kim),김선건(Sun-Gun Kim),정승일(Seung-IL Jeong),장민정(Min-Jung Jang),김길수(Kil-Soo Kim),김극준(Keuk-Jun Kim),곽승준(Seung-Jun Kwack) 한국생명과학회 2017 생명과학회지 Vol.27 No.4

본 연구는 포도수확 후 버려지는 가지를 이용한 포도전정가지 추출물(Grape Pruning Stem Extracts, GPSE)에 함유된 polyphenol류 중 항산화, 항염증, 항암 등의 효과가 있다고 알려진 rutin, procyanidin B3, quercetin, kaempferol의 함량을 분석하고, UVB로 유도된 HR-1 mice의 손상된 피부에 대한 피부 보습, 피부 증식 억제, 항염증 등의 효과를 측정하여 기능성식품, 기능성 화장품 소재로서의 응용 가능성을 확인하고자 하였다. 포도전정가지에서 polyphenol 성분을 80% EtOH로 추출하고 여과하여 농축한 후, 동결건조하여 -20℃에 보관하면서 사용하였다. GPSE의 유효성분 함량은 HPLC를 사용하여 분석하였다. 피부손상을 유도하기 위해 UVB를 실험동물에 조사하였고, GPSE의 효능을 확인하기 위하여 TEWL assay, 피부조직의 H&E staining 및 COX-2 단백 발현 측정을 위한 면역조직화학적염색(immunohistochemical stain) 등을 실시하였다. 포도전정가지 시료 53 kg에서 EtOH 분획 추출물 2.34 kg을 추출하여 4.42%의 수율 결과를 얻었다. 유효성분 분석 결과, procyanidin B3, 0.28 mg/g, rutin 12.81 mg/g, quercetin 0.51 mg/g 및 kaempferol 8.24 mg/g로 나타났다. TEWL assay 결과 대조군과 비교, GPSE와 serum base의 혼합물이 도포된 그룹(농도 2,000 mg/kg~125 mg/kg)에서 모두 보습효과가 있는 것을 확인하였다(p<0.05). GPSE의 피부증식억제를 통한 광보호 효과를 확인한 결과 epidermis에는 GPSE 농도 2,000mg/kg의 농도에서 suncream과 유사한 결과를 얻을 수 있었고(p<0.05), dermis의 두께를 측정한 결과 GPSE 농도 2,000 mg/kg~125 mg/kg 모든 농도에서 UVB 조사한 그룹 두께 800 μm와 비교하여 suncream 도포군이 580 μm, GPSE 2,000 mg/kg~125 mg/kg 모든 농도에서 600 μm이하로 나타나 UVB에 의해 손상된 HR-1 mice의 피부증식억제를 확인할 수 있었다(p<0.05). GPSE가 UVB에 의해 손상된 HR-1 mice 피부에 항염증 정도를 확인하기 위해 COX-2 단백발현을 보기위해 immunohistochemical stain한 결과 UVB를 조사한 대조군에 비해 GPSE를 도포한 그룹 모두에서 항염증 효과를 보였지만, GPSE의 농도 1,000 mg/kg에서는 suncream 22%보다 낮은 8%에서 COX-2의 단백발현이 낮은 것으로 나타나 우수한 항염증효과를 얻을 수 있었다(p<0.05). 본 연구 결과에서, GPSE 내 rutin, kaempferol, quercetin, procyanidin B3와 같은 유효성 페놀성 화합물이 확인되었으며, GPSE는 보습효과, 피부증식억제효과, 염증발현억제효과 및 자외선 손상에 의한 피부장벽 기능 개선효과 등이 있는 것으로 확인되었다. 결론적으로 GPSE는 피부보호 효과의 가능성이 있는 기능성 물질로서 기능성 식품 및 기능성 화장품 등의 원료로 활용성이 높을 것으로 판단된다. This study intends to analyze the contents of rutin, procyanidin B3, quercetin, kaempferol, known to have antioxidant, anti-inflammatory and anti-carcinogenic effects, among the polyphenol type contained in the grape pruning stem extracts (GPSE), utilizing grape stems being discarded after harvest, measure the effects on the skin moisture, inhibition of skin cell proliferation, anti-inflammatory on the damaged skin of a HR-1 mice induced with UVB, and verify the applicability as a material for functional food and functional cosmetics. The results of verifying the photoprotection effects through the skin proliferation control through of GPSE showed similar result to suncream was achieved at the GPSE concentration of 2,000 mg/kg on the epidermis (p<0.05). The results showed anti-inflammatory effects on all groups applied with GPSE as compared to the control group irradiated with UVB, but at the GPSE concentration of 1,000 mg/kg, a lower COX-2 protein expression at 8%, lower than the 22% of suncream, was observed to achieve an excellent anti-inflammatory effect (p<0.05). The results of this study confirmed the existence of active polyphenol type, such as rutin, kaempferol, querocetin and procyanidin B3, within the GPSE, and GPSE has improvement effects on moisturizing effects, skin proliferation control effect, inflammatory control effect and improvement effects on the skin barrier function through UV ray damage. GPSE is a functional ingredient with a potential for skin protection effects, and has high utilization as an ingredient for functional food and functional cosmetics.

唐代 後期 商人對象 雜稅와 商稅

金貞姬(Kim Joung-hee) 역사학회 1995 역사학보 Vol.146 No.-

당대의 吏部 銓選과 관료 인사

金貞姬(Kim, Joung-Hee) 동양사학회 2012 東洋史學硏究 Vol.121 No.-

포도전정가지 추출물이 UVB로 유도된 결합 조직 손상에 미치는 피부 보호 효과

김정희(Joung-Hee Kim),김극준(Keuk-Jun Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.2

본 연구는 포도수확 후 버려지는 가지를 이용한 포도전정가지 추출물(Grape Pruning Stem Extracts, GPSE)에 함유된 polyphenol류 중 항산화, 항염증, 항암 등의 효과가 있다고 알려진 rutin, procyanidin B3, quercetin, kaempferol의 함량을 분석하고, UVB로 유도된 HR-1 mice의 손상된 피부에 대한 교원섬유, 탄력섬유 파괴억제 효과를 측정하여 기능성 화장품 소재로서의 응용 가능성을 확인하고자 하였다. 포도전정가지에서 polyphenol 성분을 80% EtOH로 추출하고 여과하여 농축한 후, 동결건조하여 -20℃에 보관하면서 사용하였다. GPSE의 유효성분 함량은 HPLC를 사용하여 분석하였다. 피부손상을 유도하기 위해 UVB를 HR-1 hairless mice에 조사하였고, 손상된 피부에 교원섬유 파괴억제 효과를 보기 위해 Masson’s trichrome stain, 탄력섬유 파괴 억제 효과를 보기 위해 Verhoeff’s elastic fiber stain, MMP-9 단백 발현을 보기 위해 면역조직화학적 염색을 실시하였다. 본 연구에 사용된 포도전정가지 시료 53 kg에서 EtOH 분획 추출물 2.34 kg을 추출하여 4.42%의 수율 결과를 얻었다. 유효성분 분석결과, procyanidin B3, 0.28 mg/g, rutin 12.81 mg/g, quercetin 0.51 mg/g 및 kaempferol 8.24 mg/g로 나타났다. GPSE와 serum base를 혼합 도포한 그룹에서 UVB에 의한 교원섬유와 탄력섬유를 분해하는 MMP-9 단백발현 결과, 대조군 대비 평균 약 90% 감소 억제하는 효과를 볼 수 있었다. 교원섬유 파괴억제 효과는 모든 농도에서 평균 24%의 억제율과, GPSE와 serum base의 혼합물 농도 2,000 mg/kg 에서 43%로 가장 우수한 교원섬유 파괴억제효과가 나타났으며, 탄력섬유파괴 억제 효과는 모든 농도에서 평균 12%의 억제율과 GPSE와 serum base의 혼합물 농도 1,000 mg/kg에서 35%로 가장 우수한 탄력섬유 파괴 억제 효과가 있는 것으로 나타났다. 이 결과는 GPSE가 진피층의 세포 외 기질에 UVB 조사에 의해 파괴되는 교원섬유, 탄력섬유의 파괴를 억제하는 작용을 한다는 것을 알 수 있었다. 이상의 결과로 포도전정가지로부터 rutin, kaempferol, quercetin, procyanidin B3 등의 폴리페놀성 화합물이 화장품 기초 원료인 serum base에 함유토록 제조된 GPSE 는 교원섬유 파괴 억제, 탄력섬유파괴 억제효과 및 피부손상 기능개선 효과의 결과를 얻을 수 있었다. 본 연구의 의의는 지역포도농가에서 수확 후 버려지는 포도전정가지에서 폴리페놀류와 같은 유효성분을 확보하여 화장품 원료로서의 활용 가치가 높을 것으로 기대된다. This study aimed to analyze the contents of rutin, procyanidin B3, quercetin, and kaempferol, known to have antioxidant, anti-inflammatory, and anti-carcinogenic effects, among the polyphenol types contained in grape pruning stem extracts (GPSE). It utilized grape stems discarded after harvest to measure the effects of GPSE on skin moisture, inhibition of skin cell proliferation, and anti-inflammatory activity on the damaged skin of HR-1 mice induced with ultraviolet B (UVB), and to verify the applicability of GPSE as a material for functional food and functional cosmetics. The polyphenol was extracted from grape pruning stems with 80% EtOH, and then the extract was used while storing at -20℃, after filtering, concentrating, and freeze-drying it. The content of an active ingredient of GPSE was analyzed using high performance liquid chromatography (HPLC). From 53 kg of the grape pruning stem specimen, 2.34 kg of the EtOH fraction extracts were extracted to achieve a 4.42% yield ratio. Analysis of the active ingredients showed 0.28 mg/g of procyanidin B3, 12.81 mg/g of rutin, 0.51 mg/g of quercetin, and 8.24 mg/g of kaempferol. After UVB irradiation on the dermis, to confirm the degree of inhibition of collagen synthesis, we examined the protein expression of MMP-9 using immunohistochemical staining. The results of this study confirm the existence of active polyphenol types, such as rutin, kaempferol, quercetin, and procyanidin B3, in GPSE. Moreover, the study found that GPSE has anti-collagenase effects and it decreases the effects of UV damage on skin barrier function. GPSE is a functional ingredient with a potential for skin protection effects, and it has high utilization potential as an ingredient for functional cosmetics.

상담자의 수퍼비전 경험이 상담자 발달에 미치는 영향: 수퍼비전 만족도의 조절효과

김정희(Joung-Hee Kim),하정희(Jung-Hee Ha) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.5

본 연구는 상담자의 수퍼비전 경험이 상담자 발달에 미치는 영향을 검토하고 상담자 수퍼비전 경험과 상담자 발달과의 관계에서 수퍼비전 만족도의 조절효과를 검증하고자 하였다. 이를 위하여 서울, 경기, 강원, 전라 지역의 공공기관, 학교, 대학교, 전문 상담기관 등에서 상담 실무에 근무하는 상담자 299명을 대상으로 연구변인들에 대한 설문지를 실시하였다. 자료분석은 SPSS 21.0 프로그램을 사용하였다. 연구결과를 살펴보면, 첫째, 개인수퍼비전 횟수와 집단수퍼비전 참여 횟수는 상담자 발달에 유의한 영향을 미치는 것으로 나타났다. 둘째, 상담자 발달에 주된 영향을 미치는 것은 상담자의 연령과 상담경력으로 나타났다. 셋째, 수퍼비전 횟수과 상담자 발달의 관계에서 수퍼비전 만족도의 조절효과를 살펴보기 위하여 수퍼비전을 개인수퍼비전 횟수와 집단수퍼비전 횟수로 나누어 각각 살펴보았다. 그 결과, 집단수퍼비전 횟수와 상담자 발달(사례이해) 간의 관계에서 수퍼비전 만족도의 조절효과가 유의하게 나타났다. 이러한 결과는 상담자들의 수퍼비전에 긍정적인 경험이 이후의 상담 성과와 상담의 질적인 측면에 유의한 영향을 준다는 것으로 해석될 수 있다. 이를 바탕으로 수퍼비전에 대한 시사점과 제한점에 대해 논하였다. This study examines the effect of a counselor"s supervision experience on counselor development, and verifies the moderating effect of supervision satisfaction on the relationship between the counselor"s supervision experience and counselor development. Data were collected via survey administered to 299 counselors who were actively engaged in counseling practice for institutions and public organizations in Seoul, Gyeonggi, Gangwon, and Jeolla regions, such as schools, universities, and professional counseling services. Data analysis was conducted using SPSS version 21.0. The results of the analysis are as follows. First, the amount of participation in individual supervision and group supervision had a significant effect on counselor development. Second, age and years of counseling experience had major effects on counselor development. Third, when the moderating effect of supervision satisfaction on the relationship between the amount of participation in individual or group supervision and counselor development was verified, it was found that supervision satisfaction had a moderating effect on the relationship between the amount of participation in group supervision and counselor development (regarding the level of understanding with cases). The result can be interpreted as meaning that a counselor"s positive supervision experience has a direct influence on the outcome and quality of counseling services. Based on these results, proposed implications are presented regarding counseling supervision.

황련(Coptidis rhizoma), 오배자(Chinese galls), 피톤치드 혼합물(Phytoncide)이 비듬균(Malassezia furfur)에 미치는 영향

김정희(Joung-Hee Kim),조용권(Yong-Kwon Cho),김병관(Byung-Kwan Kim),곽승준(Seung Jun Kwack),김종국(Jong Guk Kim),이은경(Eunkyung Lee),조혜경(Hye-Kyung Cho),김극준(Keuk-Jun Kim) 한국생명과학회 2015 생명과학회지 Vol.25 No.7

본 연구는 기존의 선행 연구된 천연물 중 항균활성이 가장 좋은 황련, 오배자, 피톤치드(Phytoncide)가 단일추출물과 추출혼합물 일 때 M. furfur의 항균활성 차이에 대한 효과를 알아보고자 하였고, 선행연구에서 비듬균에 대한 천연한방추출물의 항균활성결과와 비교하였다. 추출혼합물에서 S. aureus는 3가지 혼합한 천연물질에서 항균활성이 내성하였으며 E. coli는 황련과의 혼합물에서 내성하였고 C. albicans는 오배자와 혼합물에서 내성이있는 것으로 나타나 각 균주에 따라 항균활성이 다른 것으로 나타났다. 반면 M. furfur는 단일추출물에서 전혀 항균활성이 없었고, 혼합물에서는 황련과 피톤치드 50% 혼합물에서 3.20mm의 직경으로 미약한 항균활성을 보였다. 이는 같은 진균인 C. albicans와 비교하여 볼 때 현저한 차이가 있었다. 그 이유는 M. furfur가 C. albicans에 비하여 세포벽이 지방친화성 성분을 지니고 있고 라멜라층, 원형질내막, 중간 다층구조로 되어있기 때문이라고 사료된다. The report explores the possibility that the single extract of natural substances and the mixture of single extracts of natural substances create a synergy effect to increase the antimicrobial activity. It also compares the previous researches to find out if the natural medicinal herbs" extract has antimicrobial activity on dandruff causative organism, Malassezia furfur. For the experiment on the mixture of single extracts of natural substances, the results are like following: 1. Staphylococcus aures"s antibacterial activity is resistant to mixture of three natural substances. 2. Escherichia coil"s antibacterial activity is resistant to mixture with Coptidis rhizoma. 3. Candida albicans" antifungal activity is resistant to mixture with Chinese galls, which means the different results may be expected when tested with each germ. 4. On the other hand, Malassezia furfur has no antifungal activity on the single extract of natural substances and shows weak antifungal activity, whose diameter is 3.20 mm when tested with the mixture of 50% of Coptidis rhizoma and 50% of Phytoncide. The result is totally different from the one on the same eumycetes, C. albicans. That is because M. furfur has more lipophilic chemicaled cell walls than C. albicans does and it also consists of lamella layer, inner plasma membrane and intermediate multiple layers.

소형 패션 리테일 샵에 나타나는 기능성 오브제의 표현특성

김정희(Kim, Joung-Hee),김진우(Kim, Jin-Woo) 한국실내디자인학회 2012 한국실내디자인학회 학술대회논문집 Vol.14 No.3

This study intends to analyse and understand various functions and representations of objet as a medium which induce consumption by stimulating the consumers" sensitivity in a small fashion retail shop. Actually modern fashion retail shops have significance to building brand identity with the emergence of strategic and innovative stores of large corporations. In the current market with plenty of retail shops, small fashion shops are showing the active attitude to present brand identity. Objet has a very important medium function in the current design tend which induces customers to a variety of image experience rather than buying stuff simply. The use of objet in a small shop with space constraint appears increasing frequency rather than the large shop. This study redefines the functional objet on the basis of previous study data and shows the expression characteristics of functional objects through 32 foreign cases. Finally the following conclusions are drawn. The functional objet shows not only one characteristic but also a variety of features and characteristics in the space of a small fashion retail shop. The functional objet expresses the important mood by inducing primarily the directionality and the flow of human traffic for space. And it gives vitality to the store by providing the unity and rhythm with repetitive expression of figurative basic elements.