사마귀양 혈관종

김장오,윤영묵,김동석,김상원 ( Jang Oh Kim,Young Mook Yoon,Dong Seok Kim,Sang Won Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

We report herein a gigantic case of verrucous hemangioma occuring in a 15 year-old school- boy. The lesion was a dark red colored, 10.0 x 6.0 x 0.8cm sized, verrucous surfaced, hemangiomatous tumor affecting the posterior aspect of the right thigh. At birth an erythematous macule appeared and insidious]y increased or extended with age. In the last 6 months, it had grown rapidly to the size of the present lesion with a smaller satellite one, assumably ascribing to the repeated minor trauma or pressure. Histological findings from the totally excised lesion showed epidermal hyperplasia with irregular acanthosis and papillomatosis and diffuse marked proliferation and dilatation of blood vessels from the upper dermis to subcutaneous fatty tissue. Wide excision was done. There was no relapse after about one years postoperative follow up. (Kor J Dermatol 1997;35(3): 584-587)

6 MV X-ray에 피폭된 흰쥐에 대한 아보카도 껍질 추출물의방사선방호효과 평가

김장오(Jang-Oh Kim,1 Ji-Hye Shin),신지혜,정도영(Do-Young Jung),전찬희(Chan-hee Jeon),이지은(Ji-Eun Lee),이윤지(Yoon-Ji Lee),민병인(Byung-In Min) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.5

본 연구의 목적은 Sprague-Dawley Rat을 통하여 아보카도 껍질추출물의 방사선방호효과를 조사하는 것이 다. 52 마리의 수컷 Rat을 무작위로 4개의 그룹으로 분류하였다. NC Group은 일반대조군, PA Group은 아보카도껍질추출물 투여군, IR Group은 방사선조사군 마지막으로 PA+IR Group은 아보카도 껍질추출물 투여 후 방사선조사군으로 설정하였다. 아보카도 껍질추출물은 방사선 조사전 14 일동안 1 일 1 회 200 mg/kg으로 경구투여를 하였으며, 방사선량은 7 Gy의 6 MV X-선을 전신조사하였다. 방사선 조사 후 4일, 21일에 실험동물을 희생하여 혈구성분, 비장 지수의 변화 및 간과 소장의 조직병리학적 평가를 수행하였다. 실험 결과, 혈구성분은 PA+IR Group이 IR Group보다 림프구(p<0.01), 적혈구(p<0.01), 혈소판(p<0.05)가 유의하게 회복하는 결과가 나타났다. 또한 Superoxide Dismutase(SOD) 활성화도 더 증가하는 것으로 확인하였다. 조직병리학적으로 간에서는 PA+IR Group에서 핵의 응집, 세포질의 팽창 등이 소폭 감소된 것이 관찰되었으며, 소장움세포의 피해에 따른 융모길이 변화에서도 유의하게 피해가 감소(p<0.01)하는 것으로 나타났다. 위의 결과를 토대로 아보카도 껍질추출물은 방사선 조사에 따른 혈구 및 주요 장기의 피해를 감소시킬 수 있는 방사선방호제 역할을 기대할 수 있다. In this study aims to investigate the radiation protection effect of avocado peel extracts on the Sprague-Dawely rats. 52 male rats were randomly classified into 4 groups. NC Group was a normal control group, PA Group was a group injected avocado peel extracts, IR Group was irradiated group, and lastly PA+IR Group was set as an irradiated group after injected of avocado peel extracts. Avocado peel extract was administered orally at 200 mg/kg once a day for 14 days before irradiation, and the radiation dose was systemically irradiated with 6 MV X-ray of 7 Gy. On the 4 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the change in blood cell composition, spleen index, and histopathological evaluation of the liver and small intestine. As a result, the PA+IR Group showed a significantly greater recovery of lymphocytes(p<0.01), red blood cells(p<0.01), and platelets(p<0.05) than the IR Group. It was also confirmed that the activation of Superoxide Dismutase(SOD) was further increased. Histopathologically, observed that nuclei aggregation and cytoplasmic expansion were slightly reduced in the PA+IR Group in the liver. and the damage was significantly reduce(p<0.01) in the change of villi length due to damage to the small intestine cells. Based on the above results, avocado peel extract can be expected to act as a radiation protection agent that can reduce damage to blood cells and major organs caused by irradiation.

백하수오 에탄올추출물이 방사선조사에 따른 흰쥐의 혈구 및 장기에 미치는 영향

김장오(Jang Oh Kim),최준혁(Jun Hyeok Choi),신지혜(Ji Hye Shin),정도영(Do Young Jung),민병인(Byung In Min) 대한방사선과학회(구 대한방사선기술학회) 2016 방사선기술과학 Vol.39 No.4

방사선 사고 및 방사선 치료 등 방사선에 의한 과피폭의 피해를 줄이기 위해 방사선방호제 개발연구는 활발히 진행되고 있다. 이에 화학적 합성물이 아닌 항산화, 항암, 면역 증강에 효과적인 것으로 알려진 백하수오를 이용하여 방사선방호효과를 확인하였다. 백하수오 에탄올추출물을 Sprague Dawley Rat (SD Rat)에 14일간 1일 1회 경구 투여하고, 7 Gy X-ray를 조사한 후 1일, 4일, 7일, 21일의 시간 변화에 따른 혈구성분, 비장 지수의 변화 및 간과 자궁의 조직변화를 관찰하였다. 실험결과 백하수오 에탄올추출물을 섭취한 실험군의 백혈구 수치(p < 0.05)와 비장 지수(p < 0.05)가 대조군보다 회복이 빠른 것을 확인하였다. 간 조직에서는 핵의 응축, 세포질의 팽창, 염증세포의 침윤이 감소하였으며, 자궁샘 조직은 세포고사가 감소한 것을 확인하였다. 위의 결과를 토대로 백하수오 에탄올추출물은 방사선 조사에 따른 혈구 및 장기의 피해를 줄일 수 있는 새로운 방사선방호제로써 유용할 것으로 기대되며, 방사선 사고와 같은 비상관리 분야에 적절한 시사점을 제공할 수 있다. The development of radioprotector is being actively conducted in order to reduce the damage from over radiation exposure at radiation accident or radiation therapy. So this study was confirmed for radiation protective effects using the Cynanchi wilfordii Radix that has been known to be effective for antioxidant activity, anti-cancer, immune enhancing effects. The method of this study was administered orally Cynanchi wilfordii Radix ethanol extracts to Sprague Dawley Rat(SD Rat) for 14 days once a day, while measuring changed blood cell, spleen index, liver and uterus tissue along the change in time of 1, 4, 7 and 21 days after X-ray beam of 7 Gy irradiation. As the result of the experiment, the experimental group’s rats which are administered with Cynanchi Wilfordii Radix ethanol extracts showed a rapid recovery in white blood cell count(p < 0.05) and spleen index(p < 0.05). In addition, condensation of nuclei, cytoplasmic swelling, and inflammatory cell infiltration in experimental group’s liver cell was decreased more than in irradiation group’s component. Further, experimental group’s Uterine gland decreased the apoptosis more than irradiation group’s components did. It is expected that Cynanchi Wilfordii Radix extracts will be useful as a new radioprotector. With above in mind, this paper may provide appropriate implications with the field of emergency management such as radiation accident.

온라인에서 소비자 감성형 SELF광고 제작 시스템 개발의 필요성 -경제적, 사회적 효과 중심으로-

김장오 ( Jang Oh Kim ) 한국정보디자인학회 2012 정보디자인학연구 Vol.19 No.-

Atypical Polypoid Dermatofibroma

김장오 ( Jang Oh Kim ),김종우 ( Jong Woo Kim ),윤영묵 ( Young Mook Yoon ),김상원 ( Sang Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

Atypical polypoid dermatofibroma(APDF) represents a distinctive clinicopathologic variant of dermatofibroma. We des~<.,ribe an unusual case of APDF occuring on the right butt~ack in a 27-year old female. The lesion was a reddish-hued, rounded, hard protuberant tumor with short pedicle, measuring 2,7 x 2.7 x 1.5cm. Excised tumor showed a well circumscribed dermal le~sion loca- lized in the protruded ar~ea, and dense proliferation of fibrobl~asts and capillaries reminiseent of fi- brous or scle~rosing hema~ngioma type, with prominent focal cellular atypia. The tumor cells were vimentin-positive, but di~rl not express CD34. There was no evidence of recurrence after 18 months postoperative foll~ow-up. (Kor J Dermatol 1996;34(5): 818-822)

흰쥐의 자궁에 대한 애엽-모링가 혼합추출물의 방사선 방호효과

이윤지(Yoon-Ji Lee),김장오(Jang-Oh Kim),전찬희(Chan-hee Jeon),이지은(Ji-Eun Lee),정근우(Geun-Woo Jeong),정도영(Do-Young Jung),민병인(Byung-In Min) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.6

본 연구의 목적은 항산화 식품으로 알려진 애엽과 모링가를 적절한 비율로 혼합하여 제조한 추출물의 방사선방호제 개발 가능성을 검토하였다. 애엽-모링가 혼합 추출물을 암컷 SD Rat 2주간 경구 투여 후 7 Gy 방사선을 조사하여 1일 7일, 21일 후에 혈구 성분의 변화, SOD활성 및 자궁의 조직 변화를 관찰하였다.AM + IR Group이 IR Group에 비하여 백혈구(p<0.05) 및 혈소판(p<0.05) 수치 회복 경향이 더 높은 것으로 확인하였다. 또한 SOD 활성을 증가시켰으며 자궁 조직에서는 세포사가 감소한 것을 확인 하였다.이 결과를 토대로 A와 B의 혼합추출물은 방사선 피폭으로 인한 혈구 및 자궁피해를 감소시킬 수 있는 방사선 방호제로서 유용할 것으로 기대된다. The purpose of this study was to examine the potential for the development of radioprotective agent in extracts manufactured by mixing Artemisia asiatica Nakai and Moringa oleifera Lam known as antioxidant food with the appropriate ratio. Their whole body were irradiated 7Gy radiation after oral administration of a mixed extract of Artemisia asiatica Nakai and Moringa oleifera Lam to SD Rat for two weeks. And 1 day, 7days, 21days later, changes in blood cell components, SOD activations and tissue changes in the uterus were observed.It was confirmed that the AM + IR group had a higher tendency to recover leukocyte (p<0.05) and platelet (p<0.05) levels than the IR group. It was also confirmed that SOD activity was increased and cell death was decreased in uterine tissue.Based on these results, the mixed extract of A and B is expected to be useful as a radiation protection agent capable of reducing blood cell and uterine damage caused by radiation exposure.

경북 중서부 지역에 집단 발생한 페데러스 피부염의 역학조사

김상원 ( Sang Won Kim ),김동석 ( Dong Seok Kim ),편세현 ( Sae Hyun Pyun ),김장오 ( Jang Oh Kim ) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.5

Background : Paederus derriattis is a peculiar linear lesion caused by an insect belonging to genus Paederus, family Staptylinidae, order Coleoptera. The deliberate or accidental contact of crushed coelomic fluid of th insect, on the skin causes acute lesions due to a t.oxin(pederin) being released. Objective : The study was nade in order to investigate an epidemic status of the peculiar der matitis and its causative agent of factor prevailing in the midwest area of Kyungpuk province. Methods : We performed field approaches on 633 cases(M: 303, F: 330) including cases enrolled in a local clinic, teamiring up with a local skin clinician over the 3-month period of August November in 1994. Results : 1. The captive insect causing the present dermatits, was identified as Paederus fuscipes(PF). The epidemic might be attributeid to the climatic conditions with higher temperature than usual during the period of July-eary September in the past year by 3-4C as well as a lower relative humidity. The active temperature zone for PF was presumed to be about 15.5+1.2C to 28.9+1.0C 2. There was the highest p;evalence of 412 cases(65.1%) in early September, followed by mid September, late August, early October and mid August in a small number of cases in decreasing order. The cases were not found after mid October. 3. All age groups were evealy represented. The sex ratio was 1: 1.1 with little difference. The majority of cases lived in Kiriich on city(80.3%), with a lesser outbreak in the neighboring coun ties and Kumi cit,y. 4. The preferred site was the mainly exposed area such as face, neck and extremities. The number of lesion was single(60%) and multiple(40%). The lesion showed a common linear con figuration and acute irritant contact dermatitis consistent with the histologic finding. Conclusion : The unusual wiather conditions and poor environmental hygiene help to develop an ecosystem breakdown, which, in urn, sometimes influences the innocuous insects life to be harm ful being on humans, as like outbreak of PF dermatitis. (Kor J Dermatol 1995;33(5): 821-829)

장결핵에 병발된 피부의 전이성 결핵성 농양

김태형 ( Tae Hyung Kim ),김장오 ( Jang Oh Kim ),신호철 ( Ho Cheol Shin ),김상원 ( Sang Won Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

We reported herein a rare case of a 65-year-old female who lead intestinal tuberculosis of about 2 months duration, with little late development of metastatit berculosis abscess of the skin. The lesions were egg tow wolnut-sized abscesses or nodules occu in, on the back, right flank and lower abdomen with no pain or mild tenderness. Physical exami saion was unremarkable on dissemination of other sites. The tuberculin test was negative. The skin esions were diagnosed by clinical, histopathologic features, and positive results for Mycobactc iuntuberculosis in smear.; and cultures in the pus discharge: as well as polymerase chain reaction nethod on the nodular lesion. A barium enema showed the findings of intestinal tuberculosis, with positive culture in the stool. A combined treatment was intituted. During the initial 4 month, utaneous lesions did not respond and in some cases worsened with the multidrug of isoniazicr fampin, pyrazinamide and streptomycin, all of which were surgically excised. Thereafter, the drugs of isoniazid and rifampin were further administered for ahout 14 months, with the complete resecution of both lesions and the systemic symptomatolo. There was no relapse at follow-up after 6 months. (Kor J Derrnatol 1995;33(3): 510-515)

수컷 쥐 전립선에 대한 타히보 추출물의 방사선 방호효과 연구

전찬희(Chan-hee Jeon),김장오(Jang-Oh Kim),이지은(Yoon-Ji Lee),이윤지(Ji-Eun Lee),이창호(Chang-Ho Lee),민병인(Byung-In Min) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.6

본 연구는 타히보 추출물이 천연 방사선 방호제로써 수컷 쥐의 전립선 내에서 일으키는 영향을 알아보기 위한 연구이다. 타히보 추출물은 유방암, 전립선 암의 세포라인에 대해 세포성장을 억제하는 능력이 있다고 알려져 있다. 수컷 쥐의 전립선을 채택하여 타히보 추출물에 의한 방사선 방호효과를 알아보기 위해 X-선 7 Gy를 조사한 날로부터 1 일, 7 일, 21 일 후의 혈액학적 변화, 외부독성평가, 항산화 효소(SOD)활성 변화 및 조직학적 변화를 관찰하였다. 타히보 투여 후 방사선 조사군은 방사선 조사군에 비해 더 큰 림프구 수치를 나타내었으며, 이 결과는 타히보가 조혈면역계의 회복능력에 영향을 미치는 것으로 사료된다. 외부독성평가결과로 타히보 추출물의 가장 높은 독성은 18.129±5.16 %, 가장 낮은 독성은 13.6945±4.43 %로 나타났다. 이는 타히보 추출물의 독성이 미미한 것으로 판단된다. 대조군 및 타히보 투여군의 전립선 세포핵 및 세포질의 구성은 균질하였으며, 이에 반해 방사선 조사군의 전립선 내 세포 핵 응집현상과 세포질 내 염증반응이 나타났다. 타히보 투여 후 방사선 조사군은 방사선 조사군에 비해 전립선 내 세포질 염증반응은 적게 나타났으나 세포핵의 응집현상이 나타났다. 이는 타히보 추출물이 전립선의 세포에 대해 방사선 방호효과가 있음으로 판단된다. This study is desinged to examine the effects of Taheebo(Tabebuia avellanedae) extract on the prostate of male rats as a natural radiation protection agent. Taheebo extract is well known to inhibit cell growth for the cell lines of breast and prostate cancer. In this study, the X-ray 7 Gy was irradiated in the prostate of male rat to identify radiation protection effects by Taheebo Extracts, 1, 7, and 21 Days later, hematological changes, external toxicity assessments(LDH), antioxidant enzyme(SOD) activity changes and tissue change were observed. IR+TH group showed greater lymphocyte levels than the irradiation group, which is believed to affect the hematopoietic immune system s resilience. As a results of the external toxicity assessment, Taheebo extract‘s toxicity is maximum 18.128±5.16%, minimum 13.6945±4.43%. Taheebo is considered to be of little toxicity. The composition of prostate cell nuclei and cytoplasm in Control and TH group was honogeneous, whereas the cell nucleus cohesion in the prostate in irradiation group and inflammatory reactions in cytoplasm were shown. IR+TH group showed less inflammatory reactions of cytoplasm in the prostate than in the radiation irradiation group, but showed a cohesive phenomenon of cell nuclei. It is judged that Taheebo extract has radiation protection against prostate cells.

컨테이너 보안 검색용 9 MeV 전자 선형가속기에서 발생한 방사화 특성평가에 관한 연구

이창호(Chang-Ho Lee),김장오(Jang-Oh Kim),이윤지(Yoon-Ji Lee),전찬희(Chan-Hee Jeon),이지은(Ji-Eun Lee),민병인(Byung-In Min) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.5

본 연구 목적은 컨테이너 보안 검색용 선형가속기에서 발생하는 방사화 특성을 평가하는 것이다. 전산모사 설계는 첫째, 표적은 텅스텐(Z=74) 단일물질 표적 및 텅스텐(Z=74)과 구리(Z=29) 복합물질 표적으로 구성하였다. 둘째, 부채꼴(Fan beam) 조준기는 물질에 따라 납(Z=82) 단일 물질과 텅스텐(Z-74)과 납(Z=82)의 복합물질로 구성하였다. 셋째 선형가속기가 위치한 방(Room)의 콘크리트는 Magnetite type 및 불순물(Impurity)을 포함하였다. 연구 방법은 첫째, MCNP6 코드를 이용하여 선형가속기 및 구조물을 F4 Tally로 광중성자 플럭스(Flux)를 계산하였다. 둘째, MCNP6 코드에서 계산된 광중성자 플럭스를 FISPACT-II에 적용하여 방사화 생성물을 평가하였다. 셋째, 방사화 생성물의 비방사능을 통해 해체 평가를 진행하였다. 그 결과 첫째, 광중성자 분포는 표적에서 가장 높게 나왔으며, 조준기 및 10 cm 깊이의 콘크리트 순으로 나타났다. 둘째, 방사화 생성물은 텅스텐 표적 및 조준기에서 W-181, 불순물이 포함된 콘크리트에서 Co-60, Ni-63, Cs-134, Eu-152, Eu-154 핵종이 부산물(by-product)로 생성되었다. 셋째, 해체 시 텅스텐 표적은 90일 이후 자체 처분 허용 농도를 만족하는 것으로 보였다. 이러한 결과는 9 MeV 에너지에서의 광중성자 수율(Yield) 및 방사화 정도가 미미한 것으로 확인할 수 있었다. 하지만, 선형가속기 텅스텐 표적 및 조준기에서 발생한 W-181은 수리를 위한 분해 시 피폭의 영향을 줄 수 있을 것으로 생각된다. 따라서, 본 연구는 컨테이너 보안 검색용 선형가속기 방사화된 부품관리에 관한 기초 자료를 제시한 것이다. 또한, 컨테이너 보안 검색용 선형 가속기 해체 시 자체처분을 만족하는 농도 기준을 입증하는데 활용될 수 있을 것으로 기대한다. The purpose of this study is to evaluate the activation characteristics that occur in a linear accelerator for container security inspection. In the computer simulation design, first, the targets consisted of a tungsten (Z=74) single material target and a tungsten (Z=74) and copper (Z=29) composite target. Second, the fan beam collimator was composed of a single material of lead (Z=82) and a composite material of tungsten (Z-74) and lead (Z=82) depending on the material. Final, the concrete in the room where the linear accelerator was located contained magnetite type and impurities. In the research method, first, the optical neutron flux was calculated using the MCNP6 code as a F4 Tally for the linear accelerator and structure. Second, the photoneutron flux calculated from the MCNP6 code was applied to FISPACT-II to evaluate the activation product. Final, the decommissioning evaluation was conducted through the specific activity of the activation product. As a result, first, it was the most common in photoneutron targets, followed by a collimator and a concrete 10 cm deep. Second, activation products were produced as by-products of W-181 in tungsten targets and collimator, and Co-60, Ni-63, Cs-134, Eu-152, Eu-154 nuclides in impurity-containing concrete. Final, it was found that the tungsten target satisfies the permissible concentration for self-disposal after 90 days upon decommissioning. These results could be confirmed that the photoneutron yield and degree of activation at 9 MeV energy were insignificant. However, it is thought that W-181 generated from the tungsten target and collimator of the linear accelerator may affect the exposure when disassembled for repair. Therefore, this study presents basic data on the management of activated parts of a linear accelerator for container security inspection. In addition, When decommissioning the linear accelerator for container security inspection, it is expected that it can be used to prove the standard that permissible concentration of self-disposal.