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산양산삼(山養山蔘)열수추출물이 db/db 마우스 당뇨모델에서 혈중 지질대사와 혈당에 미치는 영향
김응래 ( Eung Lae Kim ),김창식 ( Chang Sik Kim ),이희영 ( Hee Young Lee ),이혜림 ( Hye Rim Lee ),김응렬 ( Eung Yeol Kim ),윤미정 ( Mi Chung Yoon ),신순식 ( Soon Shik Shin ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.2
Objectives:We investigated the effects of mountain cultivated ginseng water boiled extract(MCG) on blood glucose and insulin levels, and examined whether lipid metabolism are improved by it in male db/db mice(a murine model of type 2 diabetes mellitus). Methods:9 weeks old, male db/db mice were divided into 5 groups: C57BL/6J normal, control, MCG-250㎎/㎏ (MCG-1), MCG-500㎎/㎏(MCG-2) and MCG-1000㎎/㎏(MCG-3). After mice were treated with MCG for 8 weeks, we measured body weight, food intake, fat weight, visceral organ weight and blood glucose, insulin and lipid levels. Results:1. We found no difference in body weight, food intake, fat weight and visceral organ weight among the animal groups. 2. Compared with controls, MCG-treated mice had lower blood glucose level and higher blood insulin levels, the magnitude of which was prominent in MCG-2. 3. Compared with controls, MCG-treated mice had lower LDL-cholesterol and higher HDL-cholesterol levels. 4. Compared with controls, MCG-treated mice had blood triglyceride and free fatty acid levels, the magnitude of which was prominent in MCG-2. 5. Blood AST and ALT concentrations were not changed by MCG, indicating MCG do not show any toxic effects. Conclusions:These results demonstrate that MCG effectively increases blood insulin level and decreases blood glucose level, blood lipid levels, and prevents and improves diabetic dyslipidemia and cardiovascular disease.