특발성 종양성 석회증 11예: 단일기관 체험

김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9

Background: Tumoral calcinosis is characterized by the deposition of calcific masses around major joints, and it often causes significant impairment of joint function. Dermatologists sometimes encounter patients with a subcutaneous hard mass around the joint. However, there are few studies about tumoral calcinosis in the dermatologic literature, especially in Korea. Objective: The aim of this study was to determine the clinical characteristics of tumoral calcinosis. Methods: We reviewed the clinical photographs, medical records, and biopsy specimens of 11 cases of tumoral calcinosis seen at our clinic in 10 years. Results: All 11 patients were female, and the mean age at onset was 58.5 years. The mean duration of the disease was 7.1 years. Most patients (9, 81.8%) presented with an asymptomatic subcutaneous hard mass around the iliac crest. None of the patients had a family history, or abnormal serum calcium, phosphorus, and parathyroid hormone levels. All patients underwent surgery for treatment. Conclusion: Tumoral calcinosis can occur sporadically without metabolic disease. Therefore, careful history taking and biochemical work-up involving the metabolism of calcium and phosphorus should be performed. If there is no peculiarityon examination, the lesion is cured by resection. Although the sample size of this study is small, it can be inferred that the characteristics of tumoral calcinosis in Korea can be described by its predominant sex preponderance and location, that is, the female sex and the iliac crest, respectively. (Korean J Dermatol 2020;58(9):596∼600)

항암치료 후 발생한 다발성 한공종 1예

김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9

A poroma is a benign adnexal neoplasm originating from the sweat gland duct. It usually presents clinically as a soft erythematous or flesh-colored papule, plaque, or nodule on the palms and soles. In most cases, poromas manifest as a solitary lesion, but rarely, multiple lesions have been reported and are defined as poromatosis. Although the pathogenesis is unclear, poromatosis is known to be associated with actinic damage, human papillomavirus infection, radiation therapy, or polychemotherapy. Herein, we describe a 53-year-old woman who had multiple erythematous papules on her feet for a year. She had a medical history of acute lymphoblastic leukemia and had undergone polychemotherapy with stem cell transplantation. To our knowledge, poromatosis related to chemotherapy is a rare entity, and our case could be attributed to the theory that using polychemotherapy can induce poromatosis. (Korean J Dermatol 2020;58(9):617∼619)

중등도-중증의 한국인 건선 환자에서 Ustekinumab 장기 투여에 따른 효과 및 안전성 연구

김연아 ( Yeona Kim ),배경남 ( Kyung-nam Bae ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoonsoo Kim ),고현창 ( Hyun-chang Ko ),김문범 ( Moon-bum Kim ),신봉석 ( Bong Seok Shin ),김병수 ( Byungsoo Kim ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.3

Background: Ustekinumab is a humanized monoclonal antibody targeting interleukin (IL)-12 and IL-23. Although popular, data on its long-term efficacy and safety in Korean patients with psoriasis are limited. Objective: To evaluate the long-term efficacy and safety of ustekinumab in Korean patients with psoriasis. Methods: A retrospective study in patients with moderate-to-severe psoriasis who had been treated with ustekinumab for at least 5 years was conducted. The sex, age, body mass index, medical records, previous psoriasis therapy, psoriasis area and severity index (PASI) scores, and adverse events were evaluated. Results: Twenty-five patients (median age 47.00 years) had been treated with ustekinumab for 5 years. The mean duration of psoriasis was 19.12±8.45 years, and the treatment duration with ustekinumab was 285.12±8.48 weeks. The baseline PASI was 17.52±7.38. PASI75 was achieved in 84% of the patients at week 28, and 96% of the patients maintained PASI75 during the 5-year follow-up period. Furthermore, 56% of patients reached PASI90 at 28 weeks, and 48% of patients maintained PASI90 for 5 years. No unexpected adverse events other than herpes zoster, herpes simplex, or elevated liver enzymes were reported. Conclusion: Ustekinumab demonstrated long-lasting efficacy with an acceptable safety profile in Korean patients with moderate-to-severe psoriasis. (Korean J Dermatol 2022;60(3):151∼158)

트렌드세터(Trend-Setter)로서 조선후기 기생의 뷰티와 패션에 관한 연구

김연아(Kim Yeona) 한복문화학회 2018 韓服文化 Vol.21 No.3

The Korean traditional costume and beauty structure have not been changed much since the period of the three States. Especially, women’s costume and make-up were more stationary. However, women’s clothes has just started to be changed from the mid-Choson period, and the clothes and make-up for Gisaeng had a great change in the late Joseon Dynasty. Gisaeng was more interested in fashion and beauty than the public did, and their class tended to seek a new change relatively faster than others. Thus, Gisaeng’s clothes style was leading a trendy fashion and beauty, and it impacted on other classes’ clothes style from the noble class to working one. As a trendsetter at that time, it affected Joseon Dynasty’s beauty behaviour and fashion structure, which has not changed for a long time. This research studied about which kinds of Gisaeng’s beauty and fashion, which adopted to change clothes style by women at that time, and did also about the way the make-up and clothes style of a special status as Gisaeng could be in vogue with which background. Through an examination of the theoretical background, it had a deep significance in the period, as well as when Gisaeng held influence over fashion in the late Joseon Dynasty. Classes of leisure were increased due to economic enhancements. In addition, a frank atmosphere of society was seen, as evidenced by Silhak. Women of the upper class wore clothing with gorgeous bottoms and skin-tight tops, which were popular among Gisaeng. Gisaeng wore sumptuous garments which subject to fewer social restrictions, in comparison to the clothing which ordinary women wore. Ordinary women had limits on their freedom, and had to wear thrifty clothes because of strict Confucianism values. Gisaeng could meet with the men of the ruling class and performed social activities as governed by Confucianism. Gisaeng became objects of attention among ordinary women. Noble women tried to imitate Gisaeng’s clothing, and ordinary women who accumulated wealth imitated Gisaeng’s sumptuous costume to hide their social status. By considering their role as trend-setters, the image of Gisaeng should be re-evaluated, as it has been distorted. A follow-up study should be conducted based on this subject’s needs.

비정규직의 세대 간 전승 : 부모세대의 직업적 지위가 자녀세대의 비정규직 여부에 미치는 영향

김연아 ( Kim Yeona ),정원오 ( Joung Wonoh ) 한국보건사회연구원 2016 한국복지패널 학술대회 논문집 Vol.9 No.-

본 연구는 한국복지패널 데이터(1~10차)를 활용하여 비정규직의 세대 간 전승 여부를 검증했다. 아버지가 비정규직이면 자녀도 비정규직일 가능성이 높다는 가정을 전제로 하여 직업적 지위의 세습 여부를 살펴보았다. 분석 결과, 지난 연구(1~8차)에 이어 이번 연구에서도 부모의 직업적 지위는 자녀의 비정규직 여부에 영향을 미치는 것으로 나타났다. 즉, 자녀의 경제활동 진입 당시 부모가 비정규직이면 자녀도 비정규직으로 입직할 가능성이 높고, 부모가 정규직이면 자녀도 정규직으로 입직할 가능성이 높았다. 부모세대의 영향력은 현직에까지 이어져 만 15세 이상 현 경제활동인구에 대한 분석에서도 같은 결과를 보였다. 물론 자녀의 직업적 지위에는 자녀 개인의 노동공급 요인(성별, 연령, 학력)과 노동수요 요인(업종, 직종, 기업 규모), 그리고 초직 경력이 부분적인 영향력을 행사하는 것으로 나타났다. 그러나 이들 요인을 통제한 상태에서 부모세대의 영향력이 검증됨으로써 직업적 지위의 세대 간 전승 현상이 확인되었다. 이러한 결과는 우리사회의 노동시장이 정규직과 비정규직이라는 형태로 분절되어 있고, 이중구조화된 분절의 정도가 세대 간 전승될 정도로 심각한 상태라는 점을 함축한다. 이론적 측면에서 보면, 인적자본론의 관점보다는 이중노동시장이론의 관점을 지지하는 결과라 할 수 있다. 노동시장의 이중구조 문제는 빈곤의 문제와 맞닿아 있다는 점에서 중요한 의미를 지닌다. 정규직 노동시장과 비정규직 노동시장이 이질적인 질서를 형성하고 양 시장 간의 이동성이 제약을 받을 경우 잦은 실업과 빈번한 직업이동을 경험하는 비정규직은 만성적인 소득불안정으로 인해 빈곤의 늪에 빠질 위험이 높다. 2차 노동시장에서의 문제가 빈곤의 악순환과 사회적 양극화의 문제와 연결되어 있다는 점을 감안하면, 비정규직 문제는 고용 총량의 관점에서가 아니라 고용 안정의 차원에서 보다 적극적인 정책 과제로 논의될 필요가 있다. 즉 비정규직 문제를 해결하기 위해서는 노동시장의 분절 해소를 위한 종합 대책을 마련하는 쪽으로 정책 방향을 전환해야 할 것이다. This research examined intergenerational job mobility(between regular and irregular work) by utilizing data of koweps(Korea Welfare Panel Study from 1st wave 2006 to 10th wave 2015). This study hypothesizes that father`s irregular occupational status leads to high possibility of his offspring`s irregular job. As it were, we assume that it is difficult to move from irregular job to regular job not only on the individual life history but also on the time of family history. Individual`s irregular work experience limits him moving to regular work and affects offspring`s regular or irregular occupational status. This hypothesis was tested through logistic regression analysis. The findings of our study are as follows. If the parents have irregular job when their offspring start to get job, the possibility that the offspring have irregular job is high. The opposition is true. If the parents have regular job, the possibility that their offspring have regular job is high. The parent`s occupational status affect their offspring`s occupational status continually, and therefore the present offspring`s job is affected if the parent have got regular work or not. Of course, the offspring`s occupational status is affected the others facts, for example, the labor supply factors(sex, age, education), the labor demand factors( industry, occupation, company size), and their entrance job experience. The most important fact is that the statistical power of the parent`s occupational status is tested after all other affecting factors have been controlled. Our research results insist the perspective of dual labor market theory, and the degree of labor market segmentation is serious level. Because of deepening labor market segmentation, it can say that dual structuring between regular worker and irregular worker were facilitated. Dual structure problem of labor market has significant meaning in terms of having relationship with poverty problem. Regular labor market and irregular labor market shape a heterogeneous order and when both labor market`s mobility is limited, irregular worker experiencing frequent unemployment and career change is at high risk because of chronic income unstability. By considering that problem in secondary labor market is linked to vicious circle of poverty and social polarization, irregular worker problem need to be regarded as active policy task in perspective of employment stability not as total employment. In other words, to solve irregular worker problem, policy stance needs to turn into comprehensive measure for easing labor market segmentation.

저색소성 선천성 평활근 과오종 1예

김종욱 ( Jongwook Kim ),이기욱 ( Giwook Lee ),신준오 ( Jun-oh Shin ),노동영 ( Dong Young Roh ),김연아 ( Yeona Kim ),원상현 ( Sang-hyeon Won ),이정수 ( Jungsoo Lee ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoonsoo Kim ),고현창 ( Hyun-chang 대한피부과학회 2024 대한피부과학회지 Vol.62 No.3

Congenital smooth muscle hamartoma is a benign proliferation of smooth muscles within the dermis. The classic form presents as well-defined, skin-colored, or hyperpigmented plaques associated with hypertrichosis. However, there have been reports of atypical forms, including a follicular spotted appearance, linear atrophic plaques, and morphea-like forms. In such cases, distinguishing congenital smooth muscle hamartomas from other cutaneous diseases can be challenging. Herein, we report on a 16-month-old boy who presented with a hypopigmented patch and hypertrichosis on his back since birth. Histopathological examination revealed mild acanthosis and well-defined smooth muscle bundles haphazardly oriented in the dermis. These bundles stained positively with Masson’s trichrome stain. Based on these findings, a definitive diagnosis of congenital smooth muscle hamartoma was established. In conclusion, an exceptionally rare case of congenital smooth muscle hamartoma with a hypopigmented appearance is reported. (Korean J Dermatol 2024;62(3):165∼168)

여성형탈모에서 저용량 경구 미녹시딜의 효과 및 안정성: 44명의 환자를 대상으로 한 단일기관 연구

김영범 ( Youngbeom Kim ),이기욱 ( Giwook Lee ),신준오 ( Jun-oh Shin ),노동영 ( Dong Young Roh ),김연아 ( Yeona Kim ),원상현 ( Sang-hyeon Won ),이정수 ( Jungsoo Lee ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoonsoo Kim ),고현창 ( Hyun-chan 대한피부과학회 2024 대한피부과학회지 Vol.62 No.3

Background: Female-pattern hair loss (FPHL) is characterized by diffuse hair thinning in the mid-frontal scalp and increased hair shedding. Although the use of low-dose oral minoxidil (LDOM) is increasing significantly in Korea, data on its use are limited. Objective: To determine the efficacy and safety of LDOM in Korean patients with FPHL. Methods: This retrospective, single-center study was conducted at Pusan National University Hospital. The study included female patients with pattern hair loss who received treatment with LDOM at 1.25 mg/d for a minimum of 6 months in combination with other treatments. Patients were eligible for LDOM addition if their previous treatments showed a limited response and the previous treatment regimen remained unchanged throughout the evaluation period. Clinical response to treatment was evaluated using the Sinclair hair loss severity scale. Results: The study included 44 females with FPHL. Before treatment, the mean Sinclair scale score was 2.77, which decreased to 2.27 after treatment. By the 3rd month, one patient (2.3%) experienced worsening, while seven patients (15.9%) showed slight improvement. By the 6th month, the treatment response was as follows: stabilization in 30 patients (68.2%), slight improvement in 13 patients (29.5%), and substantial improvement in one patient (2.3%). Adverse effects, predominantly hypertrichosis, were observed in nine patients. All adverse effects improved upon discontinuation of LDOM and no life-threatening adverse effects were observed during the study. Conclusion: This study provides evidence that LDOM can be an effective therapeutic option with a good safety profile for FPHL. (Korean J Dermatol 2024;62(3):136∼142)

다발성 밀크커피반점이 동반된 변이형 터너증후군 1예

이기욱 ( Gi-wook Lee ),김연아 ( Yeona Kim ),원상현 ( Sang-hyeon Won ),배경남 ( Kyung-nam Bae ),이정수 ( Jungsoo Lee ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoon-soo Kim ),김병수 ( Byung-soo Kim ),김문범 ( Moon-bum Kim ),고현창 ( Hyun-ch 대한피부과학회 2023 대한피부과학회지 Vol.61 No.4

The phenotypic variability of variant Turner syndrome is wide, ranging from characteristic clinical features to those that are hardly distinguishable from the general population. A 4-year-old girl presented with multiple brownish macules and patches on the trunk and upper extremities as well as axillary freckles. Exome sequencing and chromosomal microarray testing revealed a microdeletion at Xp22.33p22.11 leading to a diagnosis of Turner syndrome. Here we describe an unusual case of variant Turner syndrome with multiple café-au-lait spots. (Korean J Dermatol 2023;61(4):244∼247)

흑염소의 건락성 림프절염 제어를 위한 소독제 효능 비교

조현우,김연아,장범순,김찬란,박건택,Cho, Hyeunwoo,Kim, Yeona,Jang, Beomsoon,Kim, Chan-Lan,Park, Kun Taek 한국식품위생안전성학회 2022 한국식품위생안전성학회지 Vol.37 No.5

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA), a chronic contagious disease in small ruminants. The prevalence of CLA has been reported to be >50% in Korean black goats. CLA is difficult to control due to a lack of efficient vaccines and treatment methods. Effective disinfection of the farm environment may be an alternative strategy for reducing the spread of C. pseudotuberculosis. The objective of this study was to evaluate the efficacy of commercial disinfectants against CLA. The six commercial disinfectants, largely composed of sodium dichloroisocyanurate, sodium hypochlorite, potassium monopersulfate triple salt, quaternary ammonium, citric acid, and copper sulfate, were tested against five different genotypes of C. pseudotuberculosis isolated from goat farms in Korea. Efficacy tests were performed in accordance with the disinfectant efficacy test guidelines recommended by the Animal and Plant Quarantine Agency of Korea with slight modifications. All disinfectants except for copper sulfate exhibited >99.99% killing efficacy under hard water conditions following 30 min of incubation, which is the recommended standard treatment time according to guidelines. The minimum bactericidal treatment time was evaluated by employing treatments for durations of 1, 5, and 15 min. The most effective compounds under hard water conditions were sodium dichloroisocyanurate, potassium monopersulfate triple salt, and sodium hypochlorite, exhibiting >99.99% killing efficacy after 1 min of treatment. In the aqueous solution forms, citric acid and the quaternary ammonium compound were the most effective, but required at least 5 min to kill >99.99% of the bacteria. The current study characterizes the killing efficacy of six commercial disinfectant active compounds against C. pseudotuberculosis. Thus, this study provides essential information regarding the efficacy of the disinfectants used to control CLA in goat farms.

식용 식물추출물의 구강 세균에 대한 항균 활성

이지혜 ( Jihye Lee ),김연아 ( Yeona Kim ),김동청 ( Dong Chung Kim ),채희정 ( Hee Jeong Chae ) 한국응용생명화학회(구 한국농화학회) 2020 Journal of Applied Biological Chemistry (J. Appl. Vol.63 No.1

식용 식물 35종의 생리활성 부위를 대상으로 70% 에탄올 추출물의 구강 세균(Streptococcus mutans, Lactobacillus casei, Staphylococcus epidermidis, Klebsiella pneumoniae)에 대한 항균 활성을 확인하였다. 35종의 식물추출물 중 항균 스펙트럼이 가장 넓고 최소저해농도가 낮은 히비스커스 꽃 추출물을 구강세균에 대한 항균 소재로 최종 선발하였다. 히비스커스 추출물의 항균 활성은 산성 조건에서 안정하였고, 열 안정성이 우수하였다. 히비스커스 추출물의 총 폴리페놀 및 총 플라보노이드 함량은 130.5 및 25.7 mg/g으로 나타났고, 유리라디칼 소거활성과 환원력의 항산화 활성이 우수하였다. Thirty-five edible plants were tested against oral bacteria (Streptococcus mutans, Lactobacillus casei, Staphylococcus epidermidis, Klebsiella pneumonia). The edible plants were extracted using 70% ethanol as a solvent. Among the thirty-five edible plants, hibiscus (Hibiscus sabdariffa) extract was selected as an effective antibacterial source because it showed the lowest minimum inhibitory concentration. The antimicrobial substances of hibiscus extract were very stable at acidic condition and at wide range of temperature 4-75℃. The total polyphenol and flavonoid contents of hibiscus extract were 130.5 and 25.7 mg/g, respectively. Also hibiscus extract showed a high degree of antioxidant activity.