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에크린성 종양에 대한 임상 및 병리조직학적 소견 -대한피부과학회 피부병리 연구분과위원회 공동연구-
신정현 ( Jeong Hyun Shin ),고재경 ( Jai Kyoung Koh ),김광호 ( Kwang ho Kim ),김명화 ( Myung Hwa Kim ),김상원 ( Sang Won Kim ),김수남 ( Soo Nam Kim ),김시용 ( Si Young Kim ),김유찬 ( You Chan Kim ),손숙자 ( Sook Ja Son ),오지원 ( C 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
Background: Various eccrine tumors are rather common diseases in clinicians. However, data on the clinicopathologic features of eccrine tumors in Korea are limited. Objective: The purpose of this study was to investigate the clinicopathologic characteristics of eccrine tumors in Korea. Methods: Two hundred and sixty five cases of eccrine tumors, seen from 2002 to 2004 in Korea, were retrospectively analyzed clinically and histopathologically. Results: The most common eccrine tumors identified within Koreans were syringoma (61%), followed by eccrine poroma (13%), eccrine hidrocystoma (9%), and nodular hidradenoma (6%). Moreover, eccrine tumors were usually found to occur in middle-aged woman as multiple asymptomatic skin-colored papules. The most common site of occurrence was the face (45%), followed by the neck (9%), scalp (5%), foot (5%), abdomen (4%), and vulvar (3%). Conclusion: The results of this study will be useful and fundamental data on eccrine tumors for clinicians and pathologists. (Korean J Dermatol 2006;44(11):1273~1283)
박영민(Young Min Park),이준영(Jun Young Lee),김시용(Si Yong Kim),조백기(Baik Kee Cho) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4
We herein report three caes of xanthogranuloma occurring in aduls representing solitary nodule or multiple papules. Blood lipid substances such as cholesterol and triglyceride were normal and extracutaneous manifestatioiis were not found in all cases. Histopathorogic findings commonly revealed a granulomatous infiltrate c(intaining foam cells, foreign body gianf. cells and Touton giant cells as well as histiocytes and lymphocytes. (Kor J Dermatol 1993;31(4):633-637)
Erlotinib (Tarceva(R))에 의해 발생한 여드름양 발진
김윤영 ( Yoon Young Kim ),김시용 ( Si Yong Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Erlotinib (Tarceva(R)) is a new anticancer agent, acting as a reversible tyrosine kinase inhibitor of the epidermal growth factor receptor. It blocks signal transduction pathways implicated in the proliferation and survival of cancer cells. Side effects of erlotinib are mostly on the skin, such as, acneiform eruption and xerosis which are related to the interruption of normal epidermal and hair follicular kinetics. Herein we report a case of a 66 year-old man diagnosed with lung cancer with distant metastasis, who developed an acneiform eruption on his face after 5 days of erlotinib. (Korean J Dermatol 2007;45(11):1183∼1186)
주혜영 ( Hye Young Ju ),김시용 ( Si Yong Kim ),강석진 ( Seok Jin Kang ),김경문 ( Gyong Moon Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Microcystic adnexal carcinoma is a rare, locally aggressive tumor with a high potential for local recurrence. It usually presents in elderly patients as a solitary, slowly growing, firm, indurated plaque on the face, and particularly on the upper lip or central face. It has occasionally been found in extra-facial locations, including the nipple, axilla and lower extremities, yet scalp involvement has been rarely reported. Histopathologically, it is a poorly circumscribed dermal tumor that shows both follicular and ductal differentiation, and it may extend into the subcutis and skeletal muscle. We report here on a case of microcystic adnexal carcinoma at an unusual site: the scalp. A 42-year-old woman presented with a 6-month history of a painful, solitary, 1 cm-sized, firm, fixed, dome-shaped nodule on the scalp, and this was accompanied by ulceration and oozing. A biopsy specimen demonstrated features of microcystic adnexal carcinoma, with both follicular and ductal differentiation. Immunohistochemical staining for CEA (carcinoembryonic antigen) was positive in the ductal structures, but this was negative in the follicular structures. (Korean J Dermatol 2008;46(10):1376∼1380)
김태윤,조상현,김시용,조백기,이숙영 (Tae Yoon Kim,Sang Hyun Cho,Si Yong Kim,Baik Kee Cho,Sook Young Lee) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2
Scleroderma is sclerosis of the skin characterized by the appearance of circumscribed or diffuse hard, smooth, ivory-colored anea that are immobile upon the underlying tissues and give the appearance of hide-bound skin. Several environmental factors and chemicals have been described as being able to induce systemic scleroderma and scleroderma-like diseases. A possible association between scleroderma and workers exposed to silica has been suggested by reports in the literature since the turn of the century. We report a 55-year-old man, with a history of Raynaud's phenomenon and dysphagia, who had been exposed to silica dust over fifteen years. He had a mask-like face, flexian deformity of fingers, and hyperpigmented induration on the skin of all the extremities and the trunk. Antinuclear antibodies were positive in nucleolar type. On radiologic study, streaky, mottled, and nodular increased densities were noted in the both lung fields and these findings were consistent with silicosis. Endoscopic and manometric examination of the esophagus represented scleroderrna esophagus. Histopathological findings were compatible with scleroderma. He was treated with azathioprine and nifedipine with good improvement. (Kor J Dermatol 1996;34(2): 322-325)
김윤영 ( Yoon Young Kim ),김시용 ( Si Yong Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.1
Eosinophilic pustular folliculitis (Ofuji`s disease) is characterized by inflammatory infiltration of the pilosebaceous units by numerous eosinophils. Clinically, recurrent crops of papules and plaques studded with sterile follicular pustules can be seen. Follicular mucinosis is a reaction pattern which occurs in the follicular epithelium and is characterized by a mucinous degeneration of the outer sheath of follicles and sebaceous glands. The condition can occur in various diseases. Herein, we report a case of a 46-year old woman who presented with a recurrent episode of papules and follicular pustules, revealing inflammatory infiltration in and around the pilosebaceous units and prominent eosinophils, in addition to follicular mucinosis. (Korean J Dermatol 2007;45(1):34~36)