http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
STZ-유도 당뇨 쥐의 지구성 운동과 α-리포익산의 심장근 손상의 억제
박준영(Park Joon-Young),조준용(Cho Joon-Yong),김승석(Kim Seong-Suk),양대승(Yang Dae-Seung),박장규(Park Jang-Kyu),조임형(Cho Lim-Hyeong),임예현(Leem Yea-Hyun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.2
The purpose of this study is to investigate whether chronic endurance exercise training and α-lipoic acid supplementation alter myocardiac damage in STZ-induced diabetic rats. In order to achieve the purpose of this study, the male Sprague-Dawley rats which were single-injected intraperitoneally with 50㎎/㎏ of streptozotocin were subject to treadmill running (28m/min, 1h/day, 5days/week, 4weeks) and were injected with α-lipoic acid (50㎎/㎏) intraperitoneally. First, HOMA-β3% was lower in STZ group, and inversely enhanced in others, especially synergistic effect seen in COM group. Second, the incline of cytosolic cytochrome C levels and active caspase-3 was declined administrated to exercise or ALA treatment. In pararelle, Bcl-2/Bax expression ratio and in myocardiac tissue were markedly reduced in STZ group, which were reversed in other groups. Finally, the levels of Cu-Zn SOD and Catalase protein expression in myocardiac tissue were markedly reduced in STZ group, and reversely increased in others. Based on the current findings, the endurance exercise and α-lipoic acid supplementation believed to suppress the STZ-induced diabetic myocardiac damage via improving antioxidant system.