건강 자원자에서 위 배출에 미치는 tadalafil의 효과

김민수 ( Min Su Kim ),장진혁 ( Jin Hyuck Chang ),김익성 ( Ek Seong Kim ),황성준 ( Seoung Joon Hwang ),장재훈 ( Jae Hoon Jahng ),김승민 ( Seung Min Kim ),유영훈 ( Young Hoon Ryu ),박효진 ( Hyo Jin Park ) 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.1

목적: 본 교실에서는 건강 자원자에서 phosphodiesterase (PDE) 5형 억제제인 sildenafil이 전체 위 배출능에는 영향이 없었으나 음식물의 위내 분포에는 영향이 있음을 보고한 적이 있다. 이에 sildenafil 보다 작용시간이 긴 것으로 알려진 tadalafil (cialis(R))은 위 배출에 어떠한 영향을 미치는지 알아보고자 하였다. 대상 및 방법: 건강한 남자 자원자 8명(평균 나이 26.4세)을 대상으로 투약 전, tadalafil 투약 30분 후, 투약 24시간 후에 위 배출 주사를 시행하여 전체 위 배출능을 알아보기 위한 지표로서 total T(1/2) (min)을 구하였고, 위내 분포를 알아보기 위한 지표 중 위 근위부에 대해서는 proximal T(1/2) (min)과 검사식 섭취 직후 위 근위부의 방사선량인 initial proximal activity (%)를, 위 원위부에 대해서는 위 원위부에서 가장 높이 기록된 방사선량인 maximal distal content (%)을 구한 다음 tadalafil 효과 및 24시간 후까지 작용 지속 여부를 확인하였다. 결과: 위 배출 주사 결과 투약 전, tadalafil 투약 30분 후, 투약 24시간 후의 total T(1/2) (min), proximal T(1/2) (min), initial proximal activity (%), maximal distal content (%)가 모두 통계학적으로 유의한 차이를 보이지 않았다. 결론: 최근 시판된 PDE 5형 억제제, tadalafil은 위 배출 및 위내 분포에 유의한 영향을 미치지 않음을 확인할 수 있었다. Background/Aims: In a previous study we demonstrated an influence of sildenafil, a phosphodiesterase (PDE) type 5 inhibitor, on intragastric food maldistribution without affecting total gastric emptying. In this we wanted to determine the effect of tadalafil (cialis(R)), which has longer duration of action than sildenafil, on gastric emptying. Methods: Eight male (mean age, 26.4 yrs) healthy volunteers were selected. Total T(1/2) (min) was measured to assess total gastric emptying before, 30 minutes and 24 hours after tadalafil intake. Proximal T(1/2) (min), initial proximal activity (%)-radioactiviy measured in the proximal body of the stomach immediately after food ingestion-, and the maximal distal content (%)-the highest radioactiviy measured in the distal body of the stomach was measured as indicators of intragastric food distribution. Results: There were no significant differences in total T(1/2) (min), proximal T(1/2) (min), initial proximal activity (%) and maximal distal content (%) before and 30 minutes and 24 hrs after intake of tadalafil. Conclusions: The recently launched PDE5 inhibitor, tadalafil, has no significant influence on total gastric emptying or intragastric food distribution. (Kor J Neurogastroenterol Motil 2006;12:31-34)

필리핀에서 유입된 망막병증을 동반한 뎅기열 1례

김승민 ( Seung Min Kim ),김동현 ( Dong Hyun Kim ),신재령 ( Jae Ryung Shin ),오치혁 ( Chi Hyuk Oh ),유정선 ( Jung Sun Yoo ),정명화 ( Myoung Hwa Jung ),박선희 ( Sun Hee Park ),문수연 ( Soo Youn Moon ),손준성 ( Jun Seong Son ),한지상 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.1

Over the last few decades, the incidence and distribution of dengue has increased. Although Korea is not an endemic area, the numbers of imported dengue cases are increasing because of an increasing number of people travelling overseas. Common symptoms of dengue are malaise, fever, musculoskeletal pain and headache. But ocular manifestations have only been reported in one case in Korea. Here, we report a case of imported dengue fever presenting with fever, petechiae and visual disturbance. This case highlights the ocular manifestations of dengue fever. Ophthalmologic evaluation should be performed in patients presenting with severe dengue fever and visual disturbances.

대후두공 주변에 발생한 경막내 축외 해면상 혈관종

김승민(Seong-Min Kim),정승영(Seung-Young Chung),정성삼(Sung-Sam Jung),박문선(Moon-Sun Park) 대한두개저학회 2006 대한두개저학회지 Vol.1 No.2

Intraparenchymal cavernous hemangioma(CH) of central nervous system(CNS) was already well known to us, but the intradural and extra-axial CH was not and very rare. This case summarizes our surgical experience intradural-extramedullary CH on foramen magnum. A 44-year-old man complained occipital headache. Magnetic resonance imaging(MRI) showed a 15mm sized well enhancing mass that slightly displaced the medulla to the right side. An angiogram showed tumor staining with feeding artery from left posterior cerebellar artery(PICA). Our diagnosis with imaging studies was extra-axial tumor including meningioma, hemangiopericytoma. A suboccipital craniectomy and C1 laminectomy were performed. An encapsulated, highly vasculized mass was visualized and removed. Mass was purely extra-axial and pathological evaluation demonstrated a CH. So this case of CH reminds the neurosurgical community to consider CH in the differential diagnosis for extra-axial mass on foramen magnum.

복사 열전달에 의한 성층권 무인 비행선의 열 특성 연구

김승민(Seung-Min Kim),이상명(Sang-Myeong Lee),박휘섭(Hwi-Seob Park),노태성(Tae-Seong Roh),최동환(Dong-Hwan Choi) 한국추진공학회 2006 한국추진공학회지 Vol.10 No.2

복사 열전달에 의한 성층권 무인 비행선의 열 특성 연구

김승민(Seung-Min Kim),이상명(Sang-Myeong Lee),노태성(Tae-Seong Roh),최동환(Dong-Hwan Choi) 한국추진공학회 2005 한국추진공학회 학술대회논문집 Vol.2005 No.11

발전용 소형가스터빈엔진 제어시스템 개발

홍성진,김승민,육심균,남삼식,Hong, Seong-Jin,Kim, Seung-Min,Yook, Sim-Kyun,Nam, Sam-Sik 한국유체기계학회 2011 한국유체기계학회 논문집 Vol.19 No.2

Small-sized gas turbine engine could be applied to various fields such as propulsion, power generation, machine driving, etc., and Doosan has been developing 5MW class gas turbine engine for power generation since 2005. To verify its design performance and operating characteristics, a gas turbine engine test facility was constructed, and control system was also established to satisfy rapid and reliable control performance. In this paper, the hardware specification and structure of control system for gas turbine engine are introduced, and test result for starting characteristics analysis and loading is also presented.

자동차 대시보드 UX디자인 트렌드 연구

박성수 ( Park Seong Su ),김승민 ( Kim Seung Min ) 한국기초조형학회 2018 기초조형학연구 Vol.19 No.5

인간이 이용하는 이동 수단은 문명 발달과 함께 지속적인 형태의 변화 과정을 거쳐 왔다. 사람에서 동물로, 사람에서 엔진으로, 그리고 현재 수소나 전기와 같은 대체 에너지로 동력의 원천이 변화하였고 이는 그동안의 개별 이동 수단 형태 변화의 원인이었다. 더 나아가 소나 말과 같은 이동 개념의 탈것이 운전자 조작 중심의 자동차 산업으로 바뀌었고, 현대 기술의 발달로 자율 주행 자동차가 등장하며 운전자 중심에서 탑승자 중심으로의 자동차 개념의 변혁을 앞두고 있다. 이러한 자동차의 기능과 가치의 변화에 따라 UX(User Experience, 사용자 경험)디자인 또한 어떻게 탑승자를 만족시켜 줄 수 있을지 새롭게 고민해야 할 시점이다. 최근 자동차의 UX는 관련 산업의 성장에 가장 중요한 요소로 작용하고 있다. 그중에서도 자동차 대시보드는 그동안의 전통적인 기능적 구성요소에서 새로운 사용자 경험을 제시하는 중요한 부분으로 부각되었다. 본 연구는 새로운 모빌리티 개념에 대응하는 UX디자인의 방향을 모색하기 위해 다음의 과정을 수행하였다. 첫째, 자동차 가치 변화에 따른 모빌리티 UX디자인의 개념 변화를 선행 연구 분석과 문헌 조사를 통해 고찰하였다. 둘째, 자동차 UX디자인 관점에서 기존 양산 차량과 컨셉카의 대시보드 역할 및 인터페이스 트렌드를 분석하였다. 그리고 셋째, 기술 동향에 따른 대시보드 디자인의 변화 요인과 추이를 분석하여 향후 대시보드 UX디자인의 새로운 가능성을 제안한다. The means of transportation used by humans have gone through continuous transformation with the development of civilization. In the past, power sources changed from animals to people, from people to engines, and now from alternative energies such as hydrogen and electricity. These changes have caused changes in the forms of transportation. Furthermore, mobile vehicles such as cows and horses have been transformed into driver-controlled auto industries. With the advent of modern technology, self-driving cars are about to transform the concept of cars from driver-centric to passenger. It is time to think anew about how the UX (User Experience) design will satisfy the occupants according to the changes in the function and value of the vehicle. Recently, UX of the automobile is becoming the most important factor in the growth of the related industry. Among them, automobile dashboards have become an important part of presenting new user experiences in traditional functional components. This study took the following steps to find the direction of the UX design in response to the new concept of mobility. A prior study and literature survey considered the conceptual change of UX design according to the value of the car. Second, we analyzed the roles of a dashboard and interface trends of existing vehicles that are being produced and concept cars from the point of view of the UX design. Third, we analyze the changes and trends in dashboard design according to technology trends and suggest new possibilities for dashboard UX design in the future.

내시경을 이용하여 경접형동 접근술로 치료한 여포 자극 호르몬 분비 뇌하수체 샘종

정종철(Jong Chul Chung),김승민(Seong Min Kim),정성삼(Sung Sam Jung),정승영(Seung Young Chung),김병준(Byung Joon Kim) 대한두개저학회 2007 대한두개저학회지 Vol.2 No.2

Follicle-stimulating hormone-secreting pituitary adenomas are rarley diagnosed and likely considered as a non-functioning pituitary tumor. Because they usually do not present until of sufficient size to cause neurologic deficits by mass effect or hypopituitarism, whereas other functioning tumors - acromegaly, prolactinoma, Cushing s disease - frequently present earlier with symptoms caused by physiologic effects of excess hormones that they secrete. 62-year-old man suffered from visual disturbance. Endocrinologic evaluation showed high serum FSH level. Suprasellar extended pituitary mass with compression to optic chiasm & cavernous sinus was imaged on MRI and removed by endoscope assisted endonasal transsphenoidal surgery. It was composed of gonadotroph showed strong immunohistochemical reactivity against FSH and LH. Uncommon pituitary tumors such as FSH-secreting adenomas can be defined early and accurately through correlation between their clinical, endocrionological, radiographic and immunohistochemical characteristics.

임상 : 전방 두개저부 병변에 대한 두개 안면 접근법; 합병증

김근식 ( Geun Sik Kim ),김승민 ( Seong Min Kim ),정승영 ( Seung Young Chung ),정성삼 ( Sung Sam Jeong ),박문선 ( Moon Sun Park ),하호균 ( Ho Gyun Ha ),김한규 ( Han Kyu Kim ) 대한뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.2

Objective￡ºThe purpose of this study is to describe the commom complications of craniofacial approaches to lesion on anterior skull base and some technical refinements to prevent the complications. Methods￡ºAuthors reviewed medical records and radiological findings of 21 operations(including 2 reoperations) of 19 patients having anterior skull base tumors treated by craniofacial approaches from 1998 to 2004 . Results￡ºTwenty-one operations showed several complications. Those were cerebrospinal fluid leakage(3), meningitis(1), anosmia(3), epidural hematoma(1), pneumocephalus(1). Cerebrospinal fluid leakage was treated by lumbar drainage. Meningitis was treated by lumbar drainage and appropriate antibiotics. Epidural hematoma and pneumocephalus were resolved spontaneously. The complication of transfrontal and transnasomaxillary approach was none. The complications of transfrontal nasal approach were anosmia(1) and epidural hematoma(1). Cerebrospinal fluid leakage(3), meningitis(1), anosmia(2), and pneumocephalus(1) arose in the transfrontal nasal-orbital approach. Conclusion￡ºMotality and morbidity of craniofacial approach is relative low. Water-tight duroplasty, strong reconstrucion of anterior skull base and lumbar drainage are important for prevention of cerebrospinal leakage. We think that the lesion of anterior skull base is safely performed by appropriate craniofacial approach and reconstruction.

임상 : 사대 척삭종의 수술 치료에 대한 비교 분석; 내시경을 이용한 경접형동 접근법의 유용성

정종철 ( Jong Chul Chung ),김승민 ( Seong Min Kim ),정성삼 ( Sung Sam Jung ),박기석 ( Ki Seok Park ),박문선 ( Moon Sun Park ),김한규 ( Han Kyu Kim ) 대한뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2

Objective:Chordomas, whether involving the clivus or simply situated anterior to the brainstem, present a technical challenge for adequate exposure and safe resection. Transsphenoidal approach is safer and easier than any other approaches, but it has some limitation of resectability in laterally extended tumor. The objective of this paper is to demonstrate the advantages of endoscope assisted transsphenoidal approach to remove paraclival lesion on the midline. Methods:Nine patients with clival chordomas underwent surgery in our institution from 2002 to 2009. There were two men and seven women who ranged in age between 4 and 59 years. Four patients underwent stage operation by both transsphenoidal surgery and transpetrosal or transcavernous surgery. Three patients underwent only transsphenoidal surgery and two underwent only transpetrosal surgery. For image guidance, both endoscope and neuronavigation system were used in all surgical procedures. Results:Gross total removal was achieved in 33.3% and subtotal removal was achieved in 55.5%. The mean follow-up period was 44.2 months. The mortality rate during the follow-up period was 11.1%. Conclusion:For accessing clival chordoma via an anterior route, visualization of the tumor with the endoscope and navigation system is readily achievable and have the advantages of confirmation the anatomy that cannot be seen in the conventional transsphenoidal approach. This study shows transsphenoidal approach become safer and easier if the tumor is located on upper two thirds of the clivus and located on the midline.