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건강한 젊은 성인에서 액상 물질 한 모금 삼킴량의 측정
김수익 ( Su Ik Kim ),강지훈 ( Ji Hun Kang ),이동익 ( Dong Ik Lee ),조정열 ( Jeong Ryul Jo ),김형준 ( Hyung Jun Kim ),이재백 ( Jae Baek Lee ),진영호 ( Young Ho Jin ),정태오 ( Tae Oh Jeong ),윤재철 ( Jae Chol Yoon ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2
Purpose: The aim of this study is to estimate one mouthful volume in a single swallow and average volume per swallow (AVS) in multiple swallows in the situation of toxic liquid poisoning. Methods: Thirty five men and 35 women were included in this study. Each subject was asked to drink one swallow and three consecutive swallows from bottle containing water and a bottle containing saline separately. We calculated one mouthful volume in a single swallow and AVS in three swallows. One mouthful volume and AVS were compared according to sex and content, respectively. One mouthful volume of water and saline was then compared with AVS of each. Results: Sixty seven adults(34 men; 26.9±3.2 years, 33 women; 25.6±2.4 years) completed the study. Men had larger one mouthful volume of water(49.1±19.9 ml vs 39.7±10.2 ml, p=0.02) and saline(20.7±10.9 ml vs 14.0±4.6 ml, p=0.004) and AVS of water(28.5±11.9 ml vs 21.5±5.9 ml, p=0.004) and saline(11.9±6.3 ml vs 7.9±2.0 ml, p=0.001) than women. One mouthful volume and AVS of saline swallow were lower than those of water swallow. AVS of three consecutive swallows was lower than one mouthful volume in water and saline swallow. Conclusion: We suggest that one mouthful volume in a single swallow is 21 ml in men and 14 ml in women and AVS in multiple swallows is 12 ml in men and 8 ml in women. AVS in multiple swallows is two-threefold lower than reference values(20~30 ml) commonly used in poisoning study.
하수오가미방이 고지혈증 SHR 및 항산화에 미치는 영향
김수익,김남욱,전상윤,홍석,Kim, Su-Ik,Kim, Nam-Uk,Jean, Sang-Yun,Hong, Seok 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4
Objectives : This study was designed to evaluate the effect of Hasuogamibang (HGB) on hyperlipidemia and antioxidant activity. Methods : For this study, we divided four groups of rats (normal WKY group, normal SHR group, high cholesterol diet and saline-treated SHR group, high cholesterol diet and HGB-treated SHR group), and observed the change of body weight, weight of liver, cholesterol, triglyceride, glucose, albumin, histologic change of liver and aorta, lipid peroxidation and antioxidant activity of liver tissue, and cholesterol gene revelation control efficiency. Results : Total-cholesterol, LDL-cholesterol, triglycerides were decreased significantly by HGB. However, HDL-cholesterol increased significantly. The tissue of liver and aorta were controlled defect by HGB on histologic study. Lipid peroxidation and SOD of liver tissue was decreased significantly by HGB. Gene revelation of ACAT and HMG CoA reductase in hepatic tissue was decreased significantly by HGB. Conclusion : This study suggests that HOB is significantly effective on hyperlipidemia and antioxidant activity.
김소은 ( So Eun Kim ),김수익 ( Su Ik Kim ),이재백 ( Jae Baek Lee ),진영호 ( Young Ho Jin ),정태오 ( Tae Oh Jeong ),조시온 ( Si On Jo ),윤재철 ( Jae Chol Yoon ) 대한임상독성학회 2015 대한임상독성학회지 Vol.13 No.2
Purpose: Acute endosulfan poisoning is rare but causes significant morbidity and mortality. The aim of our study is to describe complications and features of seizure and determine factors associated with mortality in acute endosulfan poisoning. Methods: Twenty-eight adult patients with acute endosulfan poisoning admitted to our emergency department during a 15-year period were studied retrospectively. The clinical features of seizure, use of antiepileptic drugs during seizure, and hospital courses were evaluated. Clinical factors between survived group and non-survived group were compared for identification of factors associated with mortality. Results: Of the 28 patients with endosulfan poisoning, 4 patients (14.3%) died and 15 (53.6%) patients developed generalized tonic-clonic seizure. Thirteen patients (46.4%) and 5 patients (17.9%) progressed to status epilepticus (SE) and refractory status epilepticus (RSE), respectively. SE and RSE were associated with mortality. Almost all significant complications including shock, acute renal failure, hepatic toxicity, rhabdomyolysis, and cardiac injury developed in SE and RSE patients. Conclusion: SE and RSE were important contributors to death in endosulfan poisoning. Emergency physicians treating endosulfan poisoning should make an effort not to progress seizure following endosulfan poisoning to SE and RSE using a rapid and aggressive antiepileptic drug.