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위암에서 E-cadherin과 β-catenin의 발현양상
김성인 ; 이광주 ; 연정민 김천대학교 2007 김천대학교 논문집 Vol.28 No.-
AIM: to invetigate the expression patterns of E-cadherin and β-catenin in fastric adenocarcinoma by immunohistochemical methods and relationship with stagings, invesiveness, metastasis to lymph node. METHODS: E-cadherin and β-catenin expression in paraffin tissue specimen which came from 10 cases of gastric carcinoma were examined by immunohisto-chemical methods. patients were performed gastrectomy at chungbuk university hospital and they were conformed gastric adenocarcinoma by histopathological diagnosis. RESULTS: Histochemical stain showed normal expression of E-cadherin and β-catenin in 2 cases of early gastric adenocarcinoma. But there were no expres- sion of E-cadherin and ß-catenin at tumor cells in 2 cases of advanced gastric adenocarcinoma. CONCLUSION: This study found that expression of E-cadherin and 8-catenin were decreased in gastric adenocarcinoma between early and advanced gastric carcinoma according to degree of tumor cell differentiation. Therefore it is thought that this study will be helpful for the presumption of diagnosis, treatment and prognosis in stomach cancer patients, but further studies on a large number of cases are needed to clarify the valuable relationship prognostic factors with the expression of E-cadherin and ß-catenin related with gastric carcinoma.
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