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급성 신부전이 합병된 심한 횡문근융해증을 유발한 Doxylamine 중독증
김성열 ( Seong Ryol Kim ),이해운 ( Hae Woon Lee ),이정연 ( Jeong Yeon Lee ),안해련 ( Hae Lyun Ahn ),조영일 ( Young Il Jo ),송종오 ( Jong Oh Song ) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.6
Doxylamine succinate is an over-the-counter drug widely used for treating. We experienced a case of severe rhabdomyolysis complicating acute renal failure after doxylamine overdose in a 24-year-old male. The maximum values of creatine kinase and creatinine level during hospitalization were 264,141 IU/L and 8.4 ㎎/dL, respectively. Oliguria on the sixth hospital day and sere treated with hemodialysis. Then, he recovered without any sequelae. To the best of our knowledge, the maximum creatine kinase level of 264,141 IU/L in the present case is the highest value anong the case reports on doxylamine-induced rhabdomyolysis and this is the first case report in Korea of doxylamine-induced severe rhabdomyolysis accompanying oliguric acute renal failure and requiring treatment with hemodialysis.