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알릴셀레늄클로로피리다진의 TBAB를 촉매로 하는 부탄올용액에서의 알킬아미노화반응 및 토오토머화반응
김샛별;박명숙 德成女子大學校 藥學硏究所 2011 藥學論文誌 Vol.22 No.-
We synthesized new organoselenium compounds that allylseleno moiety at 3-position of pyridazine nucleus was introduced to yield allylselenium compounds and the 6-position was substituted with nitrogen (N) atom containing alkyl moieties. Imines 3a~d were synthesized from the 3-allylseleno-6-chloropyridazine by refluxing in n-butanol for 18〜36h with catalytic tetra-w-butyl ammonium bromide (TBAB) through alkylimination. We studied structures of synthetic organoselenium compounds and proposed the alkylimination through tautomerization and alkylamination. The target compounds 3a~d were characterized by solution NMR spectroscopy (^1 H, ^13 C).
알킬아미노피리다진을 포함하고 있는 유기셀레늄 화합물의 NMR 동태
김샛별,박명숙 덕성여자대학교 약학연구소 2010 藥學論文誌 Vol.21 No.-
We synthesized new organoselenium compounds that allylseleno moiety at 3-position of pyridazine nucleus was introduced to yield allylselenium compounds and the 6-position was substituted with oxygen(O), sulfur(S) and nitrogen(N) atom containing alkyl moieties. We studied structures of organoselenium compounds. The compounds were characterized by solution NMR spectroscopy (1H, 13C, 2D experiments).
김채원,김샛별,정주희,박명숙 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.6
A new series of 3-alkylseleno-6-alkylaminopyridazines, 3-alkylseleno-6-alkyliminopyridazines, and 3-alkylseleno-6-dialkylaminopyridazines was synthesized from 3,6-dichloropyridazine for development of new anticancer agents. The process involves the selenylation, Se-alkylation, and aralkylamination (or imination). The alkylamines such as ethylamine and the dialkylamines such as dipropylamine were introduced into the 3-position of the pyridazine ring. These new compounds showed antiproliferative activities against breast cancer (MCF-7) and hepatocellular carcinoma (Hep3B) cells in CCK-8 assays and could be promising candidates for chemotherapy of carcinomas.