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- 저자 : 김상우 ( Gim Sang U ) (검색결과 1 건)
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조유경 ( Jo Yu Gyeong ),최명규 ( Choe Myeong Gyu ),김세희 ( Kim Se Hui ),이인석 ( I In Seog ),김상우 ( Gim Sang U ),정인식 ( Jeong In Sig ),이상열 ( I Sang Yeol ),최석채 ( Choe Seog Chae ),설상영 ( Seol Sang Yeong ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.3
Background/Aims: It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on the symptom and life quality of patients with functional dyspepsia using the Nepean dyspepsia index-Korean version (NDI-K), a reliable and validated disease-specific quality of life questionnaire. Methods: A single, open trial was performed in 129 patients with functional dyspepsia. Patients were received mosapride 5 mg t.i.d before each meal for 4 weeks. The symptoms and quality of life were measured with the NDI-K at baseline and 4 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores. Results: All the 15 symptom scores and the dyspepsia score decreased after treatment (p<0.05). The total symptom score decreased from 60.9±25.8 to 24.7±20.4 (p=0.001). Correlations were observed between the total symptom score and the NDI-K score (r=0.47, p=0.001), and between the total symptom score and each score in 5 subscales (r=0.25-0.44, p=0.001). The NDI-K score was significantly increased in the effective group whose dyspepsia score decreased more than 50% of the score at baseline, compared with that of ineffective group. Any significant adverse effect and prolongation of QT interval were not occurred in all patients. Conclusions: A prokinetic drug, mosapride improves the symptoms and the quality of life in patients with functional dyspepsia. (Korean J Gastroenterol 2004;43:160-167)
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