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위 십이지장질환 환자들의 위액내 Fungus 에 관한 연구
정정명(Jung Myung Chung),박주열(Joo Youl Park),문기석(Key Seack Moon),김병제(Byoung Je Kim),김동민(Dong Min Kim),최하진(Ha Jin Choi) 대한내과학회 1986 대한내과학회지 Vol.31 No.1
N/A It is widely known that with recent environmental changes and improved methods of diagnosis, infection of fungi in a number of human organ is steadily increasing. Despite a few reports made by scientists on the relationship between candida infection and gastroenteric diseases, the infection and growth of fungi in a stomach and gastric juices has been seldom reported. In cases of gastric and duodenal disease, however, enviornmental changes within a stomach such as changes of gastric juices, disturbances of gastric motility and impairment of gastric mucosa are likely to come about, it can, therefore, be assumed that the growth of various fungi in a stomach and gastric juices is possible. Recently we have investigated the fungal infection in gastric juices aspirated from various gastroduodenal disease patients and obtained following results. 1) 40 patients have vague epigastric pain complaints for a long duration, although no definite pathological findings are endoscopically recognizable in stomach and duodenum, 16 duodenal ulcer patients, 30 gastric ulcer patients and 30 stomach cancer patients were studied on fungal growth in their salivas and gastric juices aspirated from their mouth and stomach. 2) pH of gastric juices from 21 patients in whom fungus was grown in their stomach aspirates was 4.85±1.45, whereas pH of gastric juices from another 21 patients in whom no fungus was grown was 1.91±0.61. A rather striking difference in their acidity between those 2 groups is recognizable, as already reported previously, 3) The frequency of fungal growth in gastric juices was found in following order. 32.5% of cases of non-ulcer, non-cancer patients, 18.8% of cases of duodenal ulcer patients, 73.3% of cases of gastric ulcer patients, and 83.3% of cases of stomach cancer patients. Among those patients who have fungal growth in their gastric juice, candida was found. 25.0% of cases of non-ulcer, non-cancer patients 6.3% of cases of duodenal ulcer patients, 60.0% of cases of gastric ulcer patients, and 70.0% of cases of stomach cancer patients. It was revealed that the frequency was rather higher in gastric ulcer and stomach cancer patients than in duodenal ulcer and non-ulcer, non-cancer patients. 4) Ten non-ulcer, non-cancer patients who had fungal growth in their gastric aspirates were, 6 cases of acute gastroenteritis, 2 cases of cirrhosis, 1 case of Parkinson's disease, and 1 case of renal stone.
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