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자궁경관임신에서 Methotrexate 치료 후 소파술을 시행한 보존적 치료
강은주(E . J . Kang),김현진(H . J . Kim),김미희(M . H . Kim),조은나(E . N . Cho),김현주(H . J . Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : To evaluate the safety and efficacy of intramuscular methotrexate injection followed by dilatation and curettage (D & C) for the treatment of ectopic cervical pregnancy. Method : Nine patients with cervical pregnancy were treated alternately with four doses of intramuscular methotrexate (1.0 mg/kg) and four doses of intramuscular folinic acid (0.1 mg/kg). On the seventh day after treatment, patients were measured for level of serum β-hCG (human chorionic gonadotropin) and underwent ultrasounds. According to the result, additional dose of MTX or curettage were done. Serum β-hCG and ultrasound were checked every week until the level of serum β-hCG and the finding of ultrasound had been normalized. Results : Eight patients showed normal level in serum β-hCG and normal finding in ultrasound after the methotrexate/folinic acid therapy followed by D & C. One of nine patients showed increase by double concentrations in serum β-hCG after the MTX/Folinic acid treatment. After intraamnionic injection of MTX, serum β-hCG titer was decreased in this case. One week later, D & C was performed. No patient was experienced severe complications. All patients who had wanted a subsequent pregnancy were conceived. Conclusion : These results suggest that methotrexate/folinic acid therapy followed by D & C is safe and effective as a primary therapy for ectopic cervical pregnancy.
이지연(J . Y . Lee),박소양(S . Y . Park),김미희(M . H . Kim),양수진(S . J . Yang),조은나(E . N . Joe) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
The amniotic band syndrome is a collection of fetal malformation associated with fibrous bands that appears to entangle or entrap various fetal parts in utero, leading to deformation, malformation, or disruption. Its pathogenesis has been still debated in the literature for many years. The associated anomalies vary from minor limb anomalies to major craniofacial defect, and visceral defects. We had experienced a case of limb anomalies due to amniotic band and presented with a brief review of literature.