http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김경진 ( Kyong Jin Kim ),김남의 ( Nam Eui Kim ),이영호 ( Yong Ho Lee ),김경아 ( Kyoung A Kim ),홍상기 ( Sang Ki Hong ),백수경 ( Su Kyung Baek ),주명진 ( Myung Jin Joo ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11
Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc. The increased risk is due to inherited mutations that impaired DNA mismatch repair. Two to three percentage of colon cancer is caused by Lynch syndrome. A family history of colon cancer occurs at a young age. We experienced one case of Lynch syndrome who had had stomach cancer, endometrial cancer and colon cancer recently. Hence we report this case with a brief review of literature.
말초혈액단핵구에서 아토피에 따른 GATA-3, c-maf, T-bet의 발현차이
신재민 ( Jae Min Shin ),임상수 ( Sang Su Lim ),홍구현 ( Gu Hyun Hong ),이호연 ( Ho Yeon Lee ),김남의 ( Nam Eui Kim ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2
Background & Objective: GATA-3 and T-bet are now considered as master transcriptional factors involving Th cell differentiation, but the roles of these factors are still uncertain in vivo. The study was to investigate the expression of these transcription factors in the peripheral blood mononuclear cells (PBMC) according to atopic status. Method: PBMCs were obtained from non-atopic controls, atopic controls, allergic rhinitis patients, atopic asthmatics, and non-atopic asthmatics. PBMCs were cultured for 48 hours, and then 12-o-tetracanoylphorbol-13-acetate (PMA) and calcium ionophore (ionomycin) were added. Expressions of mRNA of cytokines, GATA-3, c-maf and T-bet were measured by RT-PCR. Result: T-bet was expressed higher in the non-atopic controls that in the other groups. GATA-3 was expressed higher in the atopic controls, allergic rhinitis patients and atopic asthmatics, but lower in the non-atopic controls. Non-atopic asthmatics showed similar levels of expression of T-bet with atopic asthmatics, but significantly lower level of expression of GATA-3 than atopic groups. Conclusion: This study suggest that transcription factors, especially GATA-3, reflect or may be related to atopic status. (Korean J Asthma Allergy Clin Immunol 2007;27:90-97)