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인삼을 경구투여한 흰쥐 심장근의 수축력 퇴화율 억제에 미치는 작용 기전 연구
신원,김낙두,오우택,고광호,Shin, Won,Kim, Nak-Doo,Oh, Uh-Taek,Ko, Kwang-Ho 대한약학회 1985 약학회지 Vol.29 No.4
It was previously reported that the deterioration rate of contractile force of the isolated heart from ginseng extract treated rat was slower than that from control. Present study was carried out to investigate the mechanism of the action of ginseng on the contractile force of the papillary muscle in terms of calcium metabolism. Rats weighing 200-300g were administered orally with ginseng ethanol extract (100mg/kg/day) for more than 10 days. The isolated papillary muscles from rat hearts were suspended in bath containing Krebs-Henseleit solution. When equilibration of contractile force of papillary muscle was reached, the rates of deterioration of contractile forces of papillary muscle from ginseng component treated rats were determined by washing with Ca-free Krebs-Henseleit solution and compared with that of normal hearts. At the beginning of washing, the rate of deterioration of contractile force of the papillary muscle was slower significantly in ginseng treated rats than in control rats, suggesting that calcium may be somehow involved in sustaining the contractility in ginseng treated hearts. Anoxia of papillary muscle with nitrogen gas to muscles inhibited the contractility, but differences between control and ginseng treated groups in the rate of deterioration were not observed. Influence of diltiazem, calcium blocker, on the contractility of papillary muscle from ginseng treated and control hearts was studied. Contractility of papillary muscle from control and ginseng treated hearts was inhibited by diltiazem in dose dependent manner but the inhibition of the ginseng treated muscles was much weak. The effect was significantly different. From the results, it seemed that slowing in deterioration rate of papillary muscle from ginseng treated hearts might be related to calcium which was mobilized from plasma membrane of internal organelle by ginseng.
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DBA / 2J Mice 에서 청각성 경련 조절에 대한 중추신경계 도파민의 역할
고광호,김낙두 ( Kwang Ho Ko,Nak Doo Kim ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.4
The effect of drug-induced changes of brain biogenic amines on audiogenic seizures was determined in DBA/2J mice. One group of mice received 1-dopa which induced a large increase in brain dopamine and norepinephrine contents. A second group of animals also received 1-dopa with diethyldithiocarbamate, a dopamine-β-hydroxylase inhibitor, pretreatment which caused an elevation of dopamine but not norepinephrine levels. A third group of mice received only diethyldithiocarbamate which did not cause any changes of brain dopamine or norepinephrine concentrations. Brain 5-hydroxytryptamine contents of mice were not changed by any of these drug treatments. There were dramatic reductions in the incidence of tonic extensor seizures in the first and the second groups of animals but not in the third group. Drug-induced reduction in seizure incidence of mice correlated with an increase in brain dopamine contents but not with changes in brain norepinephrine.
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흰쥐 뇌에서의 Presynaptic alpha-Receptor와 MAO 활성의 상관 관계
이경주(Kyoung Joo Lee),김낙두(Nak Doo Kim),고광호(Kwang Ho Ko) 대한약학회 1984 약학회지 Vol.28 No.6
Relationship between hypertension and monoamine oxidase (MAO) activity in rat brain and the change of this relationship by presynaptic alpha-receptor agonist were studied. Animals were divided into three groups. Group I was composed of normotensive Sprague-Dawley rats (NR), group II of spontaneously hypertensive rats (SHR) and group III of acquired hypertensive rats induced by deoxycorticosterone acetate (DOCA) and NaCl treatment. Clonidine, a presynaptic alpha-receptor agonist, was administered to groups II and III. Blood pressures and MAO activities were measured in each group. MAO activities in the brain of SHR were lower than those of NR. Animals in group II received clonidine which lowered blood pressures but did not change MAO activities in the brain. DOCA and NaCl induced hypertension 21 days after these treatments in group III and did not cause any changes in brain MAO activity. Clonidine lowered blood pressures of group III but did not study suggest that abnormaly low MAO activities in SHR brain may be one of the underlying factors for the susceptibility to hypertension and that the decrease in noradrenergic neuronal activities through presynaptic alpha-receptor activation by clonidine may not be related to the changes of brain MAO activities.
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감초의 분획과 Glycyrrhizin이 황소정랑의 Prostaglandin Synthetase 활성에 미치는 효과
조영선(Young Sun Joe),김낙두(Nak Doo Kim),고광호(Kwang Ho Ko) 한국생약학회 1986 생약학회지 Vol.17 No.2
The investigation aimed to study the effects of methanol fraction of licorice (FM 100) and glycyrrhizin on prostaglandin synthetase activity, in relation to their analgesic effects. Effects of FM 100 and glycyrrhizin on the activity of prostaglandin synthetase extracted from bull seminal vesicles were examined by the modified method of Takeguchi et al. The analgesic effect of FM 100 was tested in mice by the acetic acid writhing method. FM 100 was administered orally to mice. BSV prostaglandin syn thetase activity was inhibited significantly by FM 100 in a dose-dependent manner, whereas the activity was slightly inhibited by glycyrrhizin. Statistically significant analgesic effects were also observed with FM 100. The results suggest that analgesic effect of licorice may be due to the inhibition of prostaglandin synthesis.
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백서에 인삼 투여시 간의 에탄올 대사 효소 활성에 미치는 효과
장명열(Myung Ryul Jang),김낙두(Nak Doo Kim),고광호(Kwang Ho Ko) 한국생약학회 1984 생약학회지 Vol.15 No.2
The investigation was aimed to study the effect of ginseng ethanol extract on the hepatic ethanol-metabolizing enzyme activity in vivo. The extract (100㎎/㎏/day) was administered orally to Sprague-Dawley rats for 7∼10 days and their microsomal ethanol oxidizing system (MEOS) and catalase activities were measured. The MEOS activity in the rat treated with the extract was not significantly different from that of the normal group. Microsomal fraction containing MEOS was separated and the MEOS activity was measured after preincubation for 5, 60 and 180 min, respectively. There were no significant differences in MEOS activities between the normal and treated groups preincubated for 5, 60 and 180 min. The activity in the rat treated with single i.p. injection of 95% CCl₄ (0.5㎖/㎏) was decreased by 48%, compared to the normal group and in the rat treated with the extract (100㎎/㎏) for 7∼10 days, the decrease of the MEOS activity was potentiated. Catalase activity in the rat treated with the extract (100㎎/㎏) was similar to that obtained from the normal group.
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