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Autoimmune Regulator Gene (Aire) is Expressed in Lymph Node Fibroblastic Reticular Cell, BLS4
Kyoung Mi Moon(문경미),Hee Ju Seo(서희주),Ji Youn Oh(오지윤),Jae Seol Lee(이재설),Hae Young Kim(김해영),Jeong-Hwan Kim(김정환),Woobong Choi(최우봉),Byung-Woo Kim(김병우),Kwang-Hyeon Kim(김광현),Jong-Hwan Lee(이종환) 한국생명과학회 2010 생명과학회지 Vol.20 No.5
Autoimmune regulator gene (Aire)는 흉선에서 발현되며 promiscuous genes으로 알려진 흉선에서 자가항원 발현을 조절한다. Aire 와 promiscuous genes은 흉선에서 T세포 tolerance와 자가면역에 관여한다. 말초 조직 즉 림프절에서 Aire의 역할을 알아보고자 림프절 구성 세포중 하나인 fibroblastic reticular cell (FRC)을 분리 확립하였다. 마우스 림프절로부터 분리된 FRC에서 Aire의 발현을 확인하였고 또한 promiscuous antigen인 insulin의 발현도 확인하였다. Aire 과발현 플라스미드로 형질전환 후 배양 FRC에서 Insulin의 발현이 증가하였다. 이것은 Aire가 FRC에서 promiscuous gene의 발현을 조절한다는 것을 보여주며 peripheral selection과 연관되어 있을 수 있다는 것을 제시한다. Autoimmune regulator gene (Aire) is expressed in the thymus and controls the expression of peripheral self-antigens, known as promiscuous genes. Aire and promiscuous genes are involved in T cell tolerance and autoimmunity in the thymus. Here, we identified Aire-expressing fibroblastic reticular cell (FRC), which was derived from mouse lymph node and also expressed in insulin promiscuous antigen. The expression of insulin was increased in cultured FRC over-expressed with Aire. These data suggest that Aire regulates promiscuous gene expression in FRC, and that this function might be under peripheral selection control.
수용성 황색색소를 분비하는 Bacillus sp. PY123균주의 분리 및 특성
김광현,김지연 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1
To develop a yellow pigment for a food-additive, a strain producing a water-soluble yellow pigment was isolated from phylloplane of tree leaf. The strain PY123 was identified a Bacillus sp. based on morphological and biochemical characterization such as a bacillus form, mortility, spore formation, Gram positive, and catalase production. The pigment production of the strain PY123 was increased about 3 times in potato broth containing 1% sucrose and 0.1 mM CoCl₂than in only potato broth after incubation at 30℃ for 2 days. When 0.1 mM CoCl₂was added in potato broth containing 1% sucrose at late log phase during incubation of the strain PY123, cell growth was not inhibited, and the period at maximal pigment production of the strain PY123 was about 12 hrs faster than in potato broth containing 1% sucrose and 0.1 mM CoCl₂simultaniously.
한식 잔반처리를 위한 호기성 미생물의 분리 및 그 분해효과
김광현,김지연,이광배 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
For the treatment of Korea food-wastes, three mesophilic and one thermophilic bacteria were isolated from soil and fermented fertilizers. The thermophilic Streptomyces sp. strain WF021 produced two enzymes which were a protease and a lipase at 55℃. The mesophilic Bacillus sp. strain WF024 produced four enzymes which were a protease, a lipase, a amylase and a cellulase when the strain was grown both at 30℃ and 55℃. The Bacillus sp. PY123 had produced three enzymes which were a protease, a cellulase and a lipase at 30℃. The Bacillus sp. strain CM1 produced three enzymes which were a protease, a amylase, and a cellulase at 30℃. The bacteria were grown in media containing 6% NaCl at least and did not have antagonism each other. The four isolates treated much more food-wastes than referance strains did. In a flask without aeration, three reference strains treated 15.4% of food-wastes, while four isolated treated 23.7% of food-wastes. In a flask with aeration, food-wastes were treated 67.3% by four isolates, and 64.3% by three reference strains, but 53.9% without bacteria. However, food-wastes were treated about 78% in a 200ℓ-reactor made by Siwon Co., while 65.8% in a 20ℓ-reactor made by Sanyo Co.