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99mTc - DMSA와 99ㅡTc - DTPA의 상대적 신섭취율을 이용한 신기능의 평가
이규보(Kyu Bo Lee),이재태(Jae Tae Lee),조동규(Dong Kyu Cho),정병천(Byung Chun Chung),최정일(Chung Il Choi),김광원(Kwang Weon Kim),권태환(Tae Hwan Kwon) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.2
N/A Background: The evaluation of individual renal function is important to diagnosis and follow-up of various diseases. Ureteral catheterization of each kidney has been widely used for this purpose, but this method had some technical difficulty, frequent complications and much restriction in reapplication. Therefore we tried to applicate radiopharmaceuticals for the evaluation of individuai renal function. Methods: We measured 2 hour, 4 hour and 24 hour relative renal uptake of 99mTc-DMSA and relative glomerular filteration rate of 99mTc-DTPA with 59 patients with various renal diseases to determine their usefulness for assessment of individual renal function and to compare correlations between every renal uptake of Tc-DMSA and relative glornerular filteration rate. Results: The correlations between 2 hour-, 4 hour- and 24 hour- relative renal uptake of 99mTc-DMSA and relative glomerular filterat.ion rate of 99mTc-DTPA were R=0.9190 (p<0.001), R=O. 9229 (p<0.001) and R=0.9917 (p<0.001). In acute obstructive uropathy, the correlations at 2 hour and 4 houre were poor as R=0.1812 (p<0.05) and R=0.4923 (p<0.05), but the correlation at 24 hour was good as R=0.9942 (p<0.001). Conclusions: We concluded that relative renal uptake at 2 hour and 4 hour had good correlation with relative DTPA uptake ratio in the cases without chronic renal failure and obstructive uropathy. Delayed image with 24 hour relative renal uptake of 99mTc-DMSA had the best correlation with relative glomerular filteration rate of 99mTc-DTPA and that might be useful in evaluation of chronic renal disease in which showed increased beckground activity or acute obstructive uropathy.
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