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혈연간 동종 조혈모세포 이식 후 이식편대숙주질환과 함께 발생한 급성 호산구성 폐렴
박환성 ( Hwan Sung Park ),옥태진 ( Tae Jin Ok ),김유재 ( You Jae Kim ),김광운 ( Guang Un Kim ),박소은 ( So Eun Park ),안지현 ( Ji Hyun An ),김윤구 ( Yun Ku Kim ),정재호 ( Jae Ho Jeong ),김수정 ( Su Jeong Kim ),이유미 ( Yu Mi Lee ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6
Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.