http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 김건표(Kyun Pyo Kim) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
개에서 자가 부분 간 이식술전후 동맥혈의 KBR ( Ketone Body Ratio ) 측정과 이식 간의 초기 기능부전 지표로서의 상관관계에 관한 연구
김상준(Sang Joon Kim),김수태(soo Tae Kim),안세현(Sei Hyun Ahn),김병식(Byung Sik Kim),정중기(Jung Kee Jung),김건표(Kyun Pyo Kim),서경석(Kyung Suk Seo) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Living-related segmental liver transplantation is now accepted as a method of liver transplantatior in pediatric group. But if graft failure occurs, mortality is high. Hence the early prediction of graft failure may contribute to the improvement of the chance of survival. The ketone bodies (acetoacetate, B-hydroxybutyrate) are known to be produced in the hepatic mitochondria. KBR (ketone body ratio) is a ratio of acetoacetate/B-hydroxybutyrate, which ref1ects the NAD+/NADH, i.e. oxidoreduction state of NAD of hepatic mitochondria. Because the viability of grafted liver is ultimately depeadant on the oxidoreduction potential of hepatic mitochondria, KBR might reflect the viability of grafted liver. The purpose of this experiment is to study whether KBR is a useful indicator of initial grat failure after liver transplantation. The experiment consisted of ten autologous left lobe liver transplants in dogs. The arterial blood was taken at preoperative period, anhepatic stage, reperfusion-15 minutes, 1 hour, 3 hour, 6 hour anl daily during their survival, and then KBR was calculated by ketone body concentration. The result of KBR measurement was as follows; it was 1.16+-0.33 at preoperative period, and abruptly decreased to 0.46+- 0.21 at anhepatic stage, and recovered to various levels according to initial graft function after reperfusion. To evaluate the initial graft function, the dogs were divided into two groups. A group (n=3) had KBR below 0.7 at reperfusion 1 hour, and B group (n=7) above 1.0. In group A, all of them showed early graft failure and died within 12 hours postoperatively. KBR changes in group A were as follows; it was 1.16 at preoperative period, and decreased to 0.25 at anhepatic stage, and recorded 0.69, 0.54, 0.61, 0.29 at reperfusion-15 min, 1 hour, 3 hour, 6 hour respectively. It never recovered above 0.7 at any period after reperfusion. In group B. they showed good early-graft function with survival of 16 hours to 8 days and died of other causes, ln group B, preoperative KBR was 1.16, and decreased to 0.54 at anhepatic stage, but promptly recovered to 0.95 at reperfusion-15 minute, 1.32 at 1 hour. It slightly decreased to 0.83 at 1 hour but maintained above 1.0 after 6 hour. In conclusion, the decreased KBR at anhepatic stage should promptly recover after reperfusion for the graft viability, and the value below 0.7 of KBR after reperfusion-1 hour represents the early graft failure, and above 1.0 of KBR represents good functioning graft. The KBR is a useful indicator of early graft function in canine autologous segmental liver transplantation, and it is assumed that KBR is further applicable on canine and human allogenic segmental liver transplantation.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
