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김윤식 ( Yoon Sik Kim ),기원진 ( Won Jin Kee ),백해경 ( Hae Kyong Back ),이상호 ( Sang Ho Lee ),신진호 ( Jin Ho Shin ) 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2
This study was carried out to review and evaluate a total of 2,463 cases of human chromosomal analysis at Kwangju Christian Hospital from 1974 to 2004. We collected 2.0-3.0ml of human peripheral blood in heparized bottle. Then, we cultured it for 72 hours. We performed GTG-banding and chromosomal kayotyping analysis by Cytovision kayotyping system. Abnormal karyotypes were observed in 30.5% of the total cases (750/2,463). Autosome and sex chromosome anomalies were observed in 25.8% (635/2,463) and 4.7% (115/2,463) respectively. In a total of 2463 cases, there were 522 (22.4%) cases of Down``s syndrome karyotype, and 67 (2.7%) cases of Turner syndrome. In conclusion, Down``s syndrome has decreased after the end of the 1990s, but other (Turner syndrome et al.) chromosomal abnormal cases haven``t decreased after the1970s.