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담관 폐쇄에 의한 백서간의 형태학적변화와 항산화효소 생성량과의 관계
박찬국,김명철,김창욱,김만우,유기동,김영학,이만재,모성환,기근홍 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Background/Aims: Obstructive cholestasis has been known to cause heaptic injury, resulting in morphological change in the liver. Rats with biliary obstruction may be believed to be susceptible to oxidative stress and free radical related liver injury by the infiltration of inflammatory cells. Using biliary obstruction in rats, we studied the relationships between morphologic changes and the levels of antioxidant enzymes. Methods: The proximal portion of the common bile duct of Sprague-Dawley rats were ligated with silk. We observed morphological changes, estimated the antioxidant enzymes within the liver tissue, and assayed aspartate aminotransferase, total bilirubin, and alkaline phosphatase within serum at every week for 4 weeks. Results: After biliary obstruction, the activities of superoxide dismutase, catalase, and glutathione peroxidase gradually increased in rat liver. Histologically, proliferation of bile ductules and fibrosis developed 3 to 4 weeks later after ligation of common bile duct. Hepatic lobular destruction and severe portal triaditis were noted 2 weeks later. Conclusions: Due to the increased activities of the antioxidant enzymes after biliary obstruction, it is believed that the oxygen free radicals play an important role in hepatic injury by cholestasis in rats, and that morphological changes may partially result from the release of oxygen free radicals by the inflammatory cells.