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소아 선천성 근성 사경의 추나 치료 효과에 대한 임상연구 고찰 - 중의학 무작위 대조군 임상연구를 중심으로 -
권효은,오수민,장수비,최일신,김기봉,천진홍,Kwon Hyo Eun,Oh Su Min,Jang Su Bi,Choi Il Shin,Kim Ki Bong,Cheon Jin Hong 대한한방소아과학회 2023 대한한방소아과학회지 Vol.37 No.2
Objective This study aimed to analyze the efficacy of the tuina treatment for congenital muscular torticollis based on randomized controlled clinical studies in China. Methods The China National Knowledge Infrastructure was the main source of data. Using the keywords "tuina", "chuna", "推拿", and "斜颈", 12 randomized controlled clinical studies were identified and analyzed. Results Compared with the control group, the tuina treatment group showed statistically significant changes with respect to the therapeutic effect. Conclusions This study suggests that tuina treatment is effective for congenital muscular torticollis patients and provides evidence for further studies on oriental medicine treatments, including tuina for congenital muscular torticollis.
Ustekinumab으로 성공적으로 치료한 뱀독에 의한 홍색피부건선 1예
권효은,신민경,정기헌 대한건선학회 2020 대한건선학회지 Vol.17 No.2
Erythrodermic psoriasis (EP) is a severe form of psoriasis that can affect nearly entire body surface area. Aggravating factors such as infection, Koebner reaction and sudden withdrawal of systemic therapy can acutely arouse erythroderma in chronic psoriasis patients. In recent studies, ustekinumab has been shown to be effective against EP which has not responded to conventional treatments. A 65-year-old female with a 6-year history of psoriasis was admitted with generalized erythema and desquamation after taking snake venom as an alternative medicine. Considering clinical manifestations and histopathologic findings, she was diagnosed as EP. She was treated with systemic corticosteroid and cyclosporine, but the remaining lesion persisted and her itching, painful symptoms did not respond to cyclosporine treatment. Ustekinumab treatment was started, and after the first injection, the patient showed remarkable improvement of psoriatic lesions. Herein, we report a case of successful treatment with ustekinumab of erythrodermic psoriasis induced by snake venom.
생쥐 소장 및 대장 카할세포의 자발적 탈분극에서 택사의 효과에 관한 비교연구
권효은,박동석,김정남,김병주 대한한의학방제학회 2022 大韓韓醫學方劑學會誌 Vol.30 No.2
Objectives : The purpose of this study was to examine the effects of Alisma canaliculatum Extract (ACE) on pacemaker potentials of small and large intestinal interstitial Cells of Cajal (ICC) in mice. Methods : We used enzymatic digestions to dissociate the ICC in the small and large intestine in mice. The whole-cell patch-clamp method was used to record pacemaker potentials in ICC. Results : 1. The ICC generated the pacemaker potentials in small intestine in mice. ACE (0.1-1mg/ml) induced membrane depolarization and decreased frequency with concentration-dependent manners. 2. Pretreatment with a Ca2+ free solution, Na+ 5 mM solution or 2-APB, a nonselective cation channel blocker, stopped the small intestinal ICC pacemaker potentials. In the case of Ca2+-free solution, Na+ 5 mM solution or 2-APB, ACE had no effects on the membrane depolarizations in small intestinal ICC. 3. The ICC generated the pacemaker potentials in large intestine in mice. Membrane depolarization appears regularly in the small intestine, but irregularly in the large intestine. ACE induced membrane depolarization (0.1-1mg/ml) and increased frequency (0.1-0.5mg/ml). 4. Pretreatment with a Ca2+ free solution, Na+ 5 mM solution or 2-APB, stopped the large intestinal ICC pacemaker potentials. In the case of Ca2+-free solution, Na+ 5 mM solution or 2-APB, ACE depolarized the membrane depolarizations in large intestinal ICC. 5. In mice, intestinal transit rate (ITR) values were dose-dependently decreased by the intragastric administration of ACE. Conclusions : These results suggest that ACE can regulate the pacemaker activity of ICC and the reaction by ACE is different from the small and large intestinal ICC, and the control of the intestinal motion by ACE may be caused by many complex processes.
Anxiety Sensitivity and Psychological Distress in Patients with Rosacea: A Questionnaire-Based Study
권효은,안혜진,신민경 대한피부과학회 2022 대한피부과학회지 Vol.60 No.4
Background: Rosacea is a common chronic inflammatory disorder that affects the skin of the central face. Anxiety sensitivity (AS) refers to the fear of sensations and symptoms arising from an expected experience of anxiety. High AS can cause anxiety disorders. Several studies have evaluated depression in patients with rosacea; however, AS has not yet been investigated. Objective: We aimed to investigate AS, depression, and quality of life in patients with rosacea. Methods: Eighty-five patients with rosacea and 85 controls (aged>18 years) were enrolled in the study. The severity of rosacea was evaluated according to the standard guidelines of the National Rosacea Society. Patients with rosacea and controls were asked to complete the Korean version of the anxiety sensitivity index-revised (ASI-R), beck depression inventory (BDI), and dermatology life quality index (DLQI). Results: The ASI, BDI, and DLQI scores were significantly higher in patients with rosacea than in controls (p< 0.001). In particular, the cardiovascular subscale of the ASI was significantly increased in patients with rosacea. The ASI and BDI scores were significantly correlated. DLQI scores were weakly correlated with ASI compared with BDI scores in patients with rosacea. Conclusion: Our study is the first to report that AS is elevated in patients with rosacea. It is necessary to consider the anxiety-related symptoms of patients with rosacea, as they may benefit from psychological intervention to alleviate distress.
이명과 난청이 GIN (Gaps-In-Noise)과 이명장애지수에 미치는 영향
권효은,김창우,이재희 한국청각언어재활학회 2015 Audiology and Speech Research Vol.11 No.2
GIN (Gaps-In-Noise) test is a clinically useful material which evaluates abilities of auditory temporal processing. Although GIN test has been evaluated from various groups and the normative data of GIN has been obtained from children to older adults, little research has focused on comparison of GIN performances in listeners with tinnitus, hearing loss, and both. The present study aimed to (1) examine the effect of tinnitus and hearing loss on GIN test for four listener groups differing in tinnitus and hearing sensitivity, (2) observe any relationship between the results of GIN test and the subjective responses of K-THI and K-TDI questionnaires. The esults showed that both tinnitus and hearing loss significantly affected GIN threshold (ms) and GIN score (%). The results of K-THI and K-TDI questionnaires demonstrate that listeners with tinnitus who performed poorer in GIN test reported greater problems in their life activities. This supports the previous findings that temporal resolution abilities can be influenced by hearing sensitivity as well as tinnitus. Thus, the GIN test can be useful to identify deficits of auditory temporal resolution in patients with tinnitus and hearing loss.
방향족 탄화수소 유기용매를 이용한 고염선택도 정삼투 분리막
권효은,김달용,이정현 한국막학회 2018 한국막학회 총회 및 학술발표회 Vol.2018 No.05
Development of forward osmosis (FO) membranes with high salt selectivity is a essential issue to realize the FO technology. To improve salt selectivity of the FO membrane, a polyamide thin film composite FO membrane was fabricated by the interfacial polymerization method using aromatic hydrocarbon organic solvents on polyacrylonitrile (PAN) supports. The aromatic hydrocarbon organic solvent accelerated amine diffusion rate toward the organic phase and the subsequent reaction, which can improve membrane performance by fabricating a thin and highly dense basal PA layer. As a result, the prepared FO membrane showed ~1.7 times higher flux and ~4.5 times higher salt selectivity compared to HTI-CTA commercial membrane with 1.0 M NaCl draw solution and DI water feed solution in FO mode.