위암에서 전이된 것으로 사료되는 피부 전이암

권호준(Ho June Kwon),오광열(Kwang Youl Oh),이규석(Kyu Suk Lee) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

Cutaneous metastases from internal carcinornas are relatively rare. The frequency of metastases to the skin varies from 0.5-4.4%. We report a case of cutaneous metastasis suspected to originat from stomach cancer. A 44-year-old female, who had an episode of total gastrectony under diagnosis of stornach cancer three years ago, had multipe painless erythernatous nodules on the case and neck for one year. Histologic findings shows atypical anaplastic cell infiltration at the derr is and subcutaneous tissues. Cells with hyperchrornatic and erally displaced nuclei were recogniz d PAS staining shows positive reactions within the cells of glarid like structure. She died twelve month after the appearance of the cutaneous lesions. (Kor J Dermetol 1994; 32(6): 1068-1071)

만성 활동성 간염 환자에서 발생한 미만성 원발성 피부 아스페르길루스증

권호준(Ho June Kwon),정재봉(Jae Bong Jung),이규석(Kyu Suk Lee),송준영(Joon Young Song) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

An 41-year-old woman with chronic active hepatitis developed multible asymptomatic erythematous papules, plaques and purpuras on the both lower leg, feet, forearms and hands. Some lesions progressed to ulcers with central black colored necrotic eschars. Biopsies and cultures demorrstrated a fungus, aspergillus fumigatus a the etilogic agent. No evicience of involvement of other organs by aspergillus fumigatus was found. Intravenous amphotericin B therapy was discontinued because of he immediate adverse effects. The patient received treatment with oral itaconazole(200mg/day) and intravenous fluconazole(400mg/day), but skin lesions have been recurring repeatedly. (Kor J Dermatol 1995; 33(1): 172-178)

최근 5년간 내원한 주사 환자 133예에 관한 임상적 고찰

구본식,권호준,김병천,이규석,송준영 ( Bon Sik Koo,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee,Joon Young Song ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3

Background: A clinical study of rosacea has never been reported in Korea. Objective : The purpose of this study was to elucidate the clinical observations of rosncea. Methods : During a 5-year-period from Jan. 1990 to Dec. 1994, 133 patients were evaluated with regard to age, sex, location of skin lesions, clinical type, duration, and precipitating factors. Results & Conclusions : 1. Of the 7,787 cases amongst outpatients, 133 cases(1.7% ) were dignosed with rosacea. Of there 46 were male patients and 87 females, giving a sex ratio of 1:1.9 in favor of females. 2. The most common type of rosacea was vascular rosacea(60.2%) 3. The average duration of rosacea was 3.4 years. 4. Rosacea afflict persons aged 40-49 most frequently. 5. The predilection sites of the rosacea were : cheek(42.9%), nose(23.3%), entire face(11.3%), cheek & nose(9%), zygomatic area(6.8%), extra-facial area(3.8%), forehead(2.9%). 6, The aggravating factors of rosacea were : unknown cause(32.3%), coffee & tea(18%), alcohol(13.5%), emotional stress(10.5%), sun exposure(9.8%), multi-factoral(7.5%), drugs(steroids) (4.6%). (Kor J Dermatol 1997;35(3): 405-410)

제1형 신경섬유종증에서 세포외 기질과 TGF - β1 유전자의 발현

정재봉,권호준,류영욱,이규석,송준영 ( Jae Bong Jung,Ho June Kwon,Young Wook Rhu,Kyu Suk Lee,June Young Song ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background: Neurofibroma, the hallmark of neurofibromatosis, is a cutaneous or subcutaneous lesion, with a variable clinical presentation. Histologically, neurofibroma consists of proliferation of nerve derived cellular elements, together with an abundant, collagenous extracellular matrix. Specifically, neurofibroma has been shown to contain 30-50% collagen in its matrix. Objective 5. methods : We examined the expression of extracellular matrix genes(collagen, fibronectin, laminin), TGF-b mRNA and Ha-ras oncogene mRNA by using Northern and slot-blot hybridization and immunoperoxidase stains. Result: In Northern blot analysis, Ha-ras and TGF-b genes revealed respectively, 8.8kb and 2. 5kb sized mRNA transcripts in neurofibroma. These parameters were normal in the control. The expression of these genes were 1.9, 2.0 fold increased in neurofibroma. In slot-blot analysis, expression of type I collagen showed fibronectin genes to be 2,401+210, 540+43, respectively, in neurofibroma. So there were 3.7 fold, 2.1 fold, differences respectively, compared to the normal control. However, there were no significant changes of type IV collagen and laminin Bl mRNA levels between neurofibroma and normal skin tissues. Irnmunoperoxidase staining by rnonoclonal anti type IV collagen antibody in neurofibroma showed type IV collagen to be diffusely and weakly stained in tissue. On staining by monoclonal anti-laminin antibody, laminin was stained in a matrix and around vessels. Conclusion : The increased expression of extracellular matrix genes may suggest that there is a subpopulation of fibroic cells in neurofibroma which are stimulated by TGF-b. Ha-ras genes which might have accumulated with the differentiation of neural tissue may be related to the pathogenesis of neurofibroma tissue formation. Further studies are needed to determine whether the other factors are related to the pathogenesis of neurofibroma. (Kor J Dermatol 1997;35(2): 249-257)

최근 10년간 피부 질환으로 응급실에 내원한 환자에 대한 통계학적 고찰 ( 1986 - 1995 )

손보성,신문석,권호준,김병천,이규석,송준영 ( Bo Sung Son,Moon Seok Sihn,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee,Joon Young Song ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.2

Background: Dermatologic emergency patients who visit the emergency room increase in number every year. But there is no report about the statistical analysis of such visits. Objectives & Method: We reviewed 326 new dermatologic emergency patients who uisited the emergency room of Dongsan Medical Center in Taegu from 1986 to 1995 to study the age, sex, monthly and yearly distributior, arrival time, length of visit, prevalence of common dermatoses, admission rate and death rate. Results : The results are summarized as follows: 1. Of 326 patients, there were 151 males and 175 females. The sex ratio of male to female was 1: 1.15. The number of patients increased with each year. 2. In age distribution, there were 23(7%) under 10;46(14%) between 11-20,55(17%) between 21-30;49(15% ) between 31-40;33(10%) between 41 50; 62(19% ) between 51-60 years,39(12% ) between 61-70 and 19(6%) between 71-80 years. 3. In monthly and arrival time distribution, the peak month incidence occurred in August(24 %), and the lowest incidence in December(1%). The peak incidence of arrival time occurred PM 6-12 hours and the lowest incidence AM 0-6 hour. 4. In the distribution about length nf visit, 73% of patients stayed more than 10 hours, 23% 5-10 hours and 4% less than 5 hours. 5. Of the most common derrnatoses, acute urticaria was seen in 124 cases(38%), and herpes zoster. in 94 cases (29%). In age distribution, acute urticaria was most preualent between the age of 0-30 and herpes zoster between 50-70. 6. The admission rate was 43%(140 cases). The death rate was 1.2%(3 cases). Conclusion : Our study of e nergency patients revealed that dermatologic emergency patients who visited the emergency room had increased in number every year and the distribution of patients is quite different from that of outpatients. (Kor J Dermatol 1997;35(2): 223-227)

간 농양과 동반된 괴저성 농창

신문석,구본식,권호준,김병천,이규석 ( Moon Seok Sihn,Bon Sik Koo,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Ecthyma Gangrenosum is a rapidly progressing skin infection charact,erized by edema, hemorragic bullae and necrosis. Ecthyma Gangrenosum occurs almost exclusively in severely imrnunocompromised patients during the course of pseudomanas aeruginosa septisemia. A 5 month-old boy was transferred to our department because of multiple well defined central necrotic black-colored large erythematous bullae. In the bacterial cultures of skin, stool and liver aspiration fluid, Pseudomonas aeruginosa was grown. In the abdominal ultrasonogram and computed tomogram, the multiple liver abscess, hepatomegaly and ascites were shown on both hepatic lobes. Herein we report a case of ecthyma gangrenosum associated with liver abscess. (Kor J Dermatol 1997;35(3): '.41-545)

The effect of UVB on the transcriptional factor, NF-kB and SP-1, activity in cultured human keratinocytes and fibroblasts treated with curcumin

류영욱 ( Young Wook Ryoo ),권호준 ( Ho June Kwon ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ) 대한피부과학회 1996 초록집 Vol.34 No.10

비전형적인 임상 양상을 보인 미만성 피부전이암

신문석 ( Moon Seok Sihn ),권호준 ( Ho June Kwon ),류영욱 ( Young Wook Ryoo ),정재봉 ( Jae Bong Jung ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.5

Cutaneous metastases from Internal carcinomas are relatively rare. We report a case of cutaneous metastasis believed t.o originate from primary lung carcinoma in a 69-year-old male patient. The patient presented with localized well defined multiple variable sized, hard eryt,hematous papules, nodules and pustules on the right chest, back and upper arm. Biopsy specimens from the nodules upper chest revealed scatt,ered islands of tumor cells and fi brosis of the dermis. To evaluate the role of p53 protein in the development of skin tumors, we examed p53 expres sion at protein level by imnunoperoxidase stain using monoclonal antimouse human p53 antibody on paraffin embeded tissues The patient died after four months from the appearance of cutaneous lesions. (Kor J Dermatol 1995;33(5): 956-960)

전신성 경피증 피부섬유아세포에서 VII형 교원질 mRNA의 검출

이규석 ( Kyu Suk Lee ),신문석 ( Moom Seok Sihn ),권호준 ( Ho June Kwon ),송준영 ( Joon Young Song ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.4

Background: Type VII collagen is a relatively low abundance extracellular matrix protein among the collagenous molecules. Among the minor collagens. type VII collagen has been demon strated by a immunolocalization studies to be component of anchoring fibrils and structures extending perpendicularly from the lamina densa to the upperpapillary dermis. Objective : The purpose of his study is to determine the expression of the type VII collagengene in a group of scleroderma patients as compared to normal skin. Methods : We have examined the levels of type VII collagen mRNA using quantitative reverse transcription PCR and in sit gybridization in scleroderma skin fibroblasts. Immunofluorescent staining with anti-type VII collan antibody was performed in vitro and in vivo to evaluate the expression of type VII collagen at protein level. Results : 1. the ratio of type VII collagen/GAPDH RT-PCR product were 63.3+15.3 in scleroderma and 21.7+7.6 in normal fibroblasts by RT-PCR. 2. The expression of type VII collagen mRNA was considerably lower than type I in scleroderma. A few positive signals by in situ hybridization with type VII collagen cDNA were shown in the dermis. 3. The staining was markedly enhanced in scleroderma fibroblasts and tissues compaired with normal subjects in imunofluorescent staining with anti-Type VII collagn antibody. Conclusion : RT-PCR and immunofluorescent staining with antibodies to type VII collagen shows enhanced gene expression in scleroderma skin fibroblasts. These data suggest that type VII collagen may be the main soruce of the sclerotic change of skin in scleroderma. (Kor J Dermatol 1996;34(4) : 591~599)

색소레이저(Pulsed Dye Laser, SPTL-1) 로 치료한 포도주색 혈관종의 임상효과에 관한 연구

김병천,이규석,신문석,송준영,정재봉,권호준 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.3

Port-wine stains(PWSs) are benign congenital vascular malformation that most commonly occur as isolated lesions on the face, neck, and trunk. The major indication for therapy, regardless of age, is psychological burden imposed by the PWSs. The pulsed dye laser(Candela SPTL-1) is a flashlamp excited dye laser, using the principles of selective photothermolysis that selectively targets the abnormal microvasculatures of cutaneous lesion while sparing adjacent structures including the epidermis, emitting at 585mm wavelength, pulse duration of 450㎲ec and 5mm spot size. From the June 1992 to May 1995, at O.P. D., Department of Dermatology, Keimyung University Hospital, 138 patients with portwine stains were analyzed to evaluate the clinical effects by the pulsed dye laser. The results were as follow : 87.9% of adults and 97.4% of children showed excellent or good results. 86.0% of male and 93.8% of female showed excellent or good results. 90.9% of head and neck, 87.5% 0f trunk, and 87.5% of extremity showed excellent or good results. Complication included transient erythema(12.3%), hyperpigmentation(7.9%), oozing(7.2%), infection(4.3%), edema(2.8%), and hypopigmentation(0.7%). There was no posttreatment sclerosis, hypertrophic or atrophic scar.