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차형기(Hyung Gi Cha),문두찬(Doo Chan Moon),권경술(Kyung Soll Kwon),정태안(Tae Ahn Chung) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
Letterer-Siwe disease is one of Langerhans cell histiocytosis, with Hand-Schuller-Christian disease and eosinophilic granuloma, characterized by proliferation of Langevha is cell. The clinical course of Letterer-Siwe disease is acute fulmunant of casionally fatal, involving skin and many other internal organs, such as the lymph node, liver, spleen, ung and bone. We present 3 cases of Letterer-Siwe disease with characteristic cutaneous findings and revealed Langerhans granules by imrriunohistochemical stain and electronmicrc scopic examination. All patients died in spite of combined chernotherapy. (Kor J Dermatol 1994; 32(1): 186-192)