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RISS 인기검색어
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- 저자 : 구석원(Suk Won Goo) (검색결과 1 건)
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구석원(Suk Won Goo),이태희(Tai Hee Lee),이기영(Kee Young Lee),이민화(Min Wha Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.6
N/A Polyamines such as putrescine, spermidine and spermine are known as uremic toxins. Preincubation of platelets with these poltamines resulted in the inhibition of platelet aggregation in response to ADP, thrombin, collagen and epinephrine. The aggregation of platelets by 40 μg/ml of collagen is completey inhibited with 10mM spermine and spermidine and delayed for 5 minutes with 10 m M putrescine. The concentrations of polyamines delaying the aggregation by collagen for 1 minute were 0.3 mM for spermine, 1 mM for spermidine and 3 mM for putrescine. Platelet aggregation by ristocetin was not affected by these polyamines. Polyamines also inhibited platelet cytosolic phos-phoinositidespecific phospholipase C activity in vitro. The concentrations of polyamines causing 50% inhibition of phospholipase C were 0.5 mM for spermine, 1.5 mM for spermidine and 10 mM for putrescine. Platelet aggregation by physiologic agonists is known to be mediated by inositol 1,4,5-triphosphate and protein kinase C. It is suggested that these polyamines inhibit platelet aggregation through inhibiting the phospholipase C and these polyamines may be causative of the bleeding tendency in uremic patients.
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