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間歇的으로 一酸化炭素에 露出된 家兎 肺胞表面 活性 物質의 活性度에 關한 硏究
郭東秀,朱永恩 慶北大學校 醫科大學 1971 慶北醫大誌 Vol.12 No.2
In an attempt to observe a possible effect of CO intoxication on the activities of pulmonary surfactant, the rabbits were exposed to 0.1% CO gas daily for two hours, and on the 1st, 3rd and 5th day of exposure, the lung extract was prepared. The activities of surfactant were measured by tension-area diagram of lung extract recorded by the modified Langmuir-Wilhelmy balance with a synchronized recording system. A comparison was made with the control, and the results obtained are summarized as follows: 1. The maximal and minimal surface tensions, width of the tension-area diagram at the surface area of 40% in lung extract, and stability index of the normal rabbit lung extracts were 31.6± 3.11dynes/㎝, 8.2±0.56 dynes/㎝, 21.4±4.40 dynes/㎝ and 1.12±0.22, respectively. 2. The activities of surfactant in the CO gas exposed group did not show any significant change from the control. 3. The above results suggest that CO gas produces no noticeable effect on the surfactant system of the lung.