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공영윤(Young Yun Kong),이관기(Kwan Ki Lee),남상윤(Sang Yun Nam),홍남두(Nam Doo Hong) 한국생약학회 1992 생약학회지 Vol.22 No.4
Phellinus linteus was examined for its anticancer activity using an animal model. Water extract of Phellinus Zinteus was prepared from artificially cultivated mycelia. Neither toxicity nor abnormal changes of hematological ` parameters were observed in the rat given orally with high doses of drug extract for 15 days. ICR mice were transplanted with Sarcoma-180 tumor cells intraperitoneally and drug extract was daily given to the mice from 1 day after tumer transplantation for 3 weeks. Administration of drug extract significantly prolonged the survival duration of Sarcoma 180-transplanted mice. For the better understanding of the anticancer activity, we have examined the effect of the drug extract administration on various killer cell functions, such as natural killer(NK) cells, cytotoxic T-lymphocytes (CTL) and macrophages which have been known to be main effector cells in immune responses against tumors. The results from the 4 hr <sup>51</sup>Cr-release assay have shown that the drug extract augments mouse NK cell activity but neither CTL nor macrophages. It is possible, then, that the anticancer activity of the Phellinus linteus may be associated with augmentation of NK cell function in the cancerated hosts.
권창호(Chang Ho Kwon),홍남두(Nam Doo Hong),김남재(Nam Jae Kim),공영윤(Young Yun Kong),장순욱(Soon Wook Chang) 한국생약학회 1988 생약학회지 Vol.19 No.3
An aromatic hydrocarbon, mp 79∼80°, C<sub>11</sub>H<sub>12</sub>O_5, was first isolated from Phyllostachys sp. and identified as 1, 4-benzenedicarboxylic acid 2`-hydroxyethyl methyl ester. Five compounds isolated after alkali hydrolysis were identified as vanillin, 4-hydroxyacetophenone, terephthalic acid, 4-hydroxybenzaldehyde and friedelin.
당귀의 Coumarin 성분연구 : Decursin의 구조이성체 Decursinol Angelate의 분리 및 정량
류경수(Kyung Soo Ryu),홍남두(Nam Doo Hong),김남재(Nam Jae Kim),공영윤(Young Yun Kong) 한국생약학회 1990 생약학회지 Vol.21 No.1
From the root of Angelica gigas Nakai, decursinol angelate was isolated, which is structural isomer of decursin. Raw material contained average 2.44% of decursinol angelate and 3.30% of decursin by the GC analysis.