http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
전기충격요법에서 Esmolol 정주가 혈압 및 심박수에 미치는 영향
김건식,신옥영,강철호 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.6
Background : Electroconvulsive therapy(ECT) that works by electrically inducing grand mal seizure is an effective therapy for patients with major psychosis and affective disorders. But ECT may produce intense stimulation of the central nervous system resulting in hypertension and tachycardia. Such an acute hyperdynamic state may be undesirable because of possible cardiovascular complications. We compared the ability of different bolus doses of esmolol to blunt the hemodynamic effects of ECT. Methods: Twenty ASA physical status 1∼2 patients were enrolled in a crossover design study to determine the effects of two standard esmolol bolus doses(0.5 mg/kg and 1.0 mg/kg) on the hemodynamic response and seizure duration during ECT. In each patients receiving esmolol or placebo, arterial pressure, heart rate, seizure duration and peripheral oxygen saturation(SpO2) were recorded. Results : The seizure duration with placebo was 43±9 sec, esmolol 0.5 mg/kg bolus dose was 39±14 sec and esmolol 1.0 mg/kg bolus dose 39±12 sec, but it was not significant. Compared with esmolol 0.5 mg/kg bolus dose, esmolol 1.0 mg/kg bolus dose decreased blood pressure and heart rate during ECT more effectively. Conclusions : Esmolol 1.0 mg/kg bolus dose was considered to be the better dose in blunting the hyperdynamic response during ECT without shortening of seizure duration. (Korean J Anesthesiol 1997; 33: 1054∼1060)