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강경덕(Kang, Kyoung-Duck),강준구(Kang, Joon-Koo),김지연(Kim, Ji-Yeon),오준호(Oh, Joon-Ho),이준철(Lee, Jun-Chul),장유리(Jang, You-Ri) 경희법학연구소 2010 KHU 글로벌 기업법무 리뷰 Vol.3 No.1
After the plan to move the administrative functions of the Capital was ruled unconstitutional by the Constitutional Court, the policy was changed and was implemented in a downsized form of moving a few number of administrative organs. However the recent government amendment which nullifies moving of any administrative organ has flamed controversy on all sides. The notion of regional equity reflects the constitutional principle of equality and it is the central idea behind local self-government. Moreover, balanced regional development will help to resolve the increasing disparity between the Greater Metropolitan area and others regions as well as increasing economic and social efficiency. We need to look at the Se-jong city issue in this context. Construction of Se-jong city was first conceived by the Park Jung-Hee regime and hence is not an issue confined to this current administration. Also this policy should not be seen as a mere appeasement to the people of Chung-Cheong province. The validity of the policy should be assessed in the wider principle and context of balanced national development. When in comparing the validity of the original legislation and the government amendment, those in favor of the amendment criticize that the original bill will harm administrative efficiency. However, this is purely a “Seoul-centric” analysis and it is inconsistent with the principle of balanced regional development. The original plan is more efficient on a nationwide scale compared with the amendment. Administrative inefficiency has to be accepted up to a certain degree as a price for balanced regional development and numerous compensative policies can be introduce to minimize the problem. Furthermore, the fact that the original plan already guarantees self-sufficiency of Se-jong as a city makes the claim that the amendment will help to create a self-sufficient city, meaningless. Therefore, the amendment is less satisfactory not only in the context of balanced regional development, but also efficiency-wise. The amendment also has a normative problem. It lacks in democratic legitimacy since there were no proper discussions involving all social voices and there were not enough objective evaluations and analyses. Also it is not in consonance with already existing legislations on balanced national development. The region selected by the amendment does not possess any notable superiority over other regions as a education-science city. Hence it is possible that it is in violation of the consitutional principle of non-discrimination since there is no rational reason for the selection. After examination of the above mentioned rationales, it can be concluded that, without extensive changes and supplementary measures, the amendment is unlikely to pass the National Assembly. If the government retracts the amendment or makes extensive changes to it as to allow part of the executive branch to move to Se-jong, we can expect that the national consensus of the location of the capital city could change as well. Then the customary constitutional principle which makes Seoul the Capital could be overturned by the Constitutional Court and more complete move of the Capital and its administrative functions can be expected to follow.
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좁은잎천선과 및 조릿대 혼합 추출물의 항산화 성분과 항산화 활성
권희연(Hee-Yeon Kwon),최선일(Sun-Il Choi),한웅호(Xionggao Han),문효(Xiao Men),장길웅(Gill-Woong Jang),최예은(Ye-Eun Choi),강준철(Jun-Chul Kang),조주현(Ju-Hyun Cho),이옥환(Ok-Hwan Lee) 한국식품과학회 2020 한국식품과학회지 Vol.52 No.4
본 연구에서는 HR02/04(8:2)-W에 대한 항산화 성분 및 생리활성을 평가하기 위하여, p-coumaric acid 함량, 총 플라보노이드 및 총 페놀 함량, DPPH, ABTS 라디칼 소거능, FRAP 활성, reducing power, ORAC value를 측정하였다. 또한, 피부 섬유아세포에서 hydrogen peroxide에 의하여 산화적 스트레스가 유도된 세포모델에서의 HR02/04(8:2)-W의 산화 손상 보호효과를 측정하기 위하여 XTT assay 및 H₂-DCFDA assay를 진행하였다. HPLC를 이용한 p-coumaric acid 함량 분석 결과, HR02/04(8:2)-W 내의 pcoumaric acid는 75.62±1.56 mg/100 g 함유되어 있는 것으로 나타났으며, 총 플라보노이드 함량 및 총 페놀 함량은 각각 21.57±0.84 mg RE/g, 21.25±1.31 mg GAE/g으로 측정되었다. DPPH 및 ABTS 라디칼 소거활성 시험에서 HR02/04(8:2)-W의 농도 유의적으로 소거활성이 증가하는 것을 확인하였으며, FRAP 활성 및 reducing power 측정에서도 우수한 항산화 활성을 보였다. ORAC assay 결과 control 보다 5배 이상 높은 수치를 보이며 효과적으로 라디칼 저해 활성을 보였다. 항산화 실험에서의 뛰어난 항산화 활성은 HR02/04(8:2)-W에 함유된 페놀류들에 의한 것으로 판단된다. 피부 섬유아세포를 이용한 실험에서, HR02/04(8:2)-W을 300 μg/mL의 농도까지 세포의 생존력에 영향을 미치지 않는 것으로 나타났으며, hydrogen peroxide 처리에 의하여 56%까지 감소되었던 세포 생존율을 최대 78%까지 증가시키며 효과적으로 세포를 보호했음을 확인하였다. H₂-DCFDA 염색을 통하여 세포내의 ROS의 양을 측정하였을 때, hydrogen peroxide처리에 의하여 control군 대비 137%까지 증가하였던 ROS를 최대 89% 까지 감소시킴으로써 세포 내 활성산소를 효과적으로 억제하였다. 이상의 결과를 종합하여 볼 때, HR02/04(8:2)-W이 뛰어난 항산화 생리활성 기능을 가지고, 세포 내 활성산소를 효과적으로 제거할 수 있는 소재임이 확인되었으며, 천연물 유래 기능성 식품원료로서의 활용 가능성이 매우 넓을 것으로 판단된다. The purpose of this study was to evaluate the antioxidant components and activities of HR02/04(8:2)-W, a mixture of S. quelpaertensis Nakai and F. erecta var. sieboldii. We investigated the p-coumaric acid, total flavonoid, and total phenol contents. To evaluate the antioxidant efficacy, we measured the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity, FRAP activity, reducing power, and ORAC value. We observed the protective effect of hydrogen peroxide against cell damage in human dermal fibroblasts. As a result of the experiment, the p-coumaric acid, total flavonoid, and total phenol contents were 75.62±1.56 mg/100 g, 21.57±0.84 mg rutin equivalent (RE)/g, and 21.25±1.31 mg gallic acid equivalent (GAE)/g, respectively. In the experiments on antioxidant activity, HR02/04(8:2)-W was found to have significantly increased antioxidant activity. In the human dermal fibroblasts, the HR02/04(8:2)-W treated groups could effectively protect cells against oxidative damage. In this study, we confirmed that HR02/04(8:2)-W is a material with effective physiological antioxidant activity.
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신봉철 ( Bong Chul Shin ),허내윤 ( Nae Yun Heo ),강미선 ( Mi Seon Kang ),이주원 ( Ju Won Lee ),박승현 ( Seung Hyun Park ),진규복 ( Kyu Bok Jin ),강준 ( Jun Kang ) 대한내과학회 2013 대한내과학회지 Vol.84 No.6
Hepatobiliary involvement is a rare manifestation of Henoch-Schonlein purpura (HSP). HSP cases related to hepatitis A, B or C virus have been reported but little is known about HSP cases complicated by cholestatic hepatitis without underlying hepatobiliary disease. Here, we report a case of Henoch-Schonlein purpura presenting with cholestatic hepatitis. The patient presented with upper abdominal pain and cholestasis that developed characteristic purpura. The patient was treated conservatively by therapeutic fasting and nutritional support, and liver function recovered 7 weeks after admission. (Korean J Med 2013;84:831-835)
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