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나환자에서 Dapsone과 Clofazimine 병용치료법
강수찬(Soo Chan Kang),서무규(Moo Gyu Suh),오수희(Su Hee Oh),정상립(Sang Lip Chung) 대한피부과학회 1985 大韓皮膚科學會誌 Vol.23 No.2
Seventy-seven patients who were treated regularly for more than 5 years in the Taegu Leprosy Mission were investigated with regard to the change of the bacillary index(BI) after treatment of either dapsone(DDS) alone or a combination of DDS and clofazimine. The results were as follows: 1) In the group that took only DDS 400-500 mg per week, the BI conversion to negative took average 51 months. 2) In the group that took only 600-700 mg per week, the BI conversion to negative took average 34 months. 3) In the group that took only DDS 400 mg per week initially and 600-700mg per week secondarily, the BI conversion to negative took average 64 months, the last 33 months of which marked the time period that 600-700 mg were taken per week. 4) In the group that took only DDS 400-500mg per week initially and a combination of DDS gpp 700 mg per week and clofazimine. 3pp-4pp mg per week secondarily, the BI conversion to negative took average 63 months, the last 35 months of which marked the time period for the combined therapy. 5) In the group that took a combination of DDS 600- 700 mg per week and clofazimine 400 mg per week, the BI conversion to negative took average 42 months.
강수찬(Soo Chan Kang),정경재(Kyung Jae Chung),전재복(Jae Bok Jun),서순봉(Soon Bong Suh) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1
Generalized granuloma annulare is manifested by numerous, symrnetrical, shiny, normal-skin colored, discrete or confluent, papular eruption on the sunexposed areas, most.ly in females of past middle age. Up to date, a variety of therapeutic approaches have been tried with inconsistent results. Recently several agents have been reported to be inconsistent results. Recently several agents have reported to be effecti e in the treatment of genealizecl granuloma annulare. Of these, dapsone has been used with favorable respones. The fact dapsone can inhibit the lysosomal enzyme release and the mononuclear cell-rnediated rnyeloperoxidase cytotaxicity would account for its effect in granuloma annulare even in part. We observed a case of generalized granulare in a 49-year old man, who had had numerous normal-skin colored or faintly violaceous, flattopped papular eruption on the sun-exposed areas for 3 years. He was treated successfully with dapsone 100mg a day for about 22 months.
박재경(Jae Kyung Park),강수찬(Soo Chan Kang),김상원(Sang Won Kim),박재복(Jae Bok Park) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.1
We herein report a case of gout, who was a 45-year-old man and had had multiple various-sized papules or tophi on the helices of ears, hands, elbows, knees, ankles and feet for 10 years. Histopathologic findings of the large tophus of right knee revealed the typical pattern of gout with needle-shaped urate crystal. The phenomenon of iransepidermal elimination was observed in serial sections of histologic speeirnerls, The nsrrow transepidermal channel, lined by pseudoepitheliomstous lips bilaterally, was Eilled with the cellular debris and urate crystal fragments and cornmunicated direotly with the upper dermis. Presumably, transepidermal elirnination in gouty tophus may be the phenomenon whieh could be found rnore commonly than the scarcity of literature. (Kor J Dermatol 28(1): 86-89, 1090)
정상립(Sang Lip Chung),강수찬(Soo Chan Kang) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.5
In order to study immunological responses in psoriatic lesions, direct immunofluorescence(DIF) findings in stratum corneum of psoriatic lesions are compared with histopathological changes. The results are summerized as follows: 1) Deposition of Igs or C 3 in stratum corneum of psoriatic lesions was demonstrated in 14(56%) of 25 psoriasis patients. IgG was present in 40% IgA in 48%, IgM in 24%, and C 3 in 32%. However, DIF findings are negative in the str,atum corneum in the uninvolved skin of psoriasiis. In control groups of 12 cases of various skin diseases, DIF findings were negative in the stratum corneum except 1 case of a patient with acne rosacea. 2)DIF findings in 22 cases of histopathologic changes of psoriatic lesions were found in 50% of hyperkeratosis in 48% of parakeratosis in 50% of Munro microabscess, in 50%, of spongiform pustule, and in 57% of the absence of stratum granulosum: ie, about only 50% were positive in DIF results. Histopathologic changes in 11 cases of positive DIF finding in psoriatic lesions were hyperkeratosis in 100%, parakeratosis in 91%, Munro microabscess in 64%, spongiform pustule in 55%, and the absence of stratum granulosum in 73%.
서무규(Moo Gyu Suh),강수찬(Soo Chan Kang),전재복(Jae Bock Jun),서순봉(Soon Bong Suh) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4
This report presents a case of metasric calcinosis cutis resembling pseudoxanthoma elasticum in clinical appearance. The patient, 19-year-old man, has dull yellowish firm folded lesion on both axillae, and immobility of lower extremities because of bony osteoporosis, knee fracture, impaired renal function, Skin biopsy, bone marrow biopsy, bone X-ray, and laboratory findings showed metastatic calcinosis cutis due to histiocytosis X and chronic renal failure.
박재경(Jae Kyung Park),편세현(Sae Hyun Pyun),강수찬(Soo Chan Kang),김상원(Sang Won Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.5
We report herein three cases of superficial migratory thrornbophlebitis, who were all male, aged 33(Case 1), 49(Case 2), and 41(Case 3), respectively. Common to all three cases were the lesions which were multiple tender superfieial erythematous nodules, about 0.5 to 1.5cm in diameter, in cord-like indurations slong the superficial veins over the legs and feet. Histopathologically, the deep dermal veins commonly showed luminal occlusions by thrombi, and inflarnmstory infiltrates of a fairly large number of lyrnphohistiocytes and a few giant cells in their walls and surrounding tissues. Cases 1 and 2 were with idiopathic type, and Cage 3was associated with Buergers disease. The systemic therapy with dipyridamole, nicotinamide, aspirin and piraicam had been tried with unsatisfactory results.
박재경(Jae Kyung Park),편세현(Sae Hyun Pyun),강수찬(Soo Chan Kang),김상원(Sang Won Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3
We reported herein a case of median raphe cysts and canal of the scrotum. The 7-year-old patient had had the beaded cysts of 0.1 to 0.5cm in size slong a cord-like canal measuring about 8cm in the median raphe of the scrotum since the birth on. The cystic wall was unilocular and lined by pseudostratified columnar epitheliurn of one to four cells in thickness.