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- 저자 : 강소군 ( Shaojun Jiang ) (검색결과 2 건)
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이승헌 ( Seung Hun Lee ),강소군 ( Shaojun Jiang ),박태현 ( Tae Hyun Park ),최승호 ( Choong Bae Yoo ),안성구 ( Eung Ho Choi ),유총배 ( Sung Ku Ahn ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3
Background: The stratum corneum(SC) has a permeability barrier function which regulates percutaneous absorption by the inhibition of transepidermal water loss(TEWL). Acute mechanical or chemical disruption of the SC induces the impairment of the permeability barrier and so increases the TEWL. The calciumtion has been recognized as an important ion in the recovery of the skin barrier. Recently the main delivery pathway of iontophoretic drugs have been suggested by SC interstices. However the morphologic changes in the SC interstices and calcium after iontophoresis have not been reported. Objective : The aim of our study is to confirm that iontophoresis may induce changes in the SC interstices and delay the recovery of the barrier after disruption. Material and Methods : After tape stripping the hairless mouse flank skin, the iontophoresis power supply (6V, 0.6mA) was connected to the patch atiached for 2.5 hours to the stripped site. We checked the THWL 0, 2.5, 6, 12, 18, 24 hours after the tape stripping and obtained specimens and performed osmium tetroxide, ruthenium tetroxide postfixation and calcium ion-capture cytochemical stains for electron microscopic study. Results : The recovery rate of the TEWL in iontophoresis was lower than in the control. This was especially so in the anouse which had received anode iontophoresis for 6 hours. It showed statistically lower TEWL than in the control(p<0.05). Anode iontophoresis induced low calcium in stratum granulosum (SG), but cathode iontophoresis induced high calcium in SC. After iontophoresis there were changes in the SC interstices structures. Conclusion : Iontophoresis can induce changes in the SC interstices and calcium distribution and so may help the topical drug delivery system. (Kor J Dermatol 1996;34(3): 375-380)
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Benzalkonium chloride 자극 후 desoxymethasone 연고 , vaseline 및 hydrobase 도포에 따른 피부장벽의 회복
안성구 ( Sung Ku Ahn ),최응호 ( Eung Ho Choi ),강소군 ( Jiang Shaojun ),황상민 ( Sang Min Hwang ),이승헌 ( Seung Hun Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Backgroud: Topical irritants disrupt the cutaneous permeability barrier through the removal of stratum comeum lipids. This perturbation of barrier integrity stimulates a variety of homeostatic repair responses that ultimately result in the normalization of bamer function. Object To measure the effect of desoxymethasone ointment, vaseline and hydrobase on the barrier recovery of benzalkonium chloride (BKC) imtated skin Materials and methods . The left flank skin of 2-3 monthold hairless mice was treated with BKC and then desoxymethasone ointment, vaseline and hydrobase were applied. Transepidermal water loss (TEWL) was checked after 0, 3, 6, 9, 12, 15, 18, 21 and 24 hours. Electron microscopic examination was performed after 3 and 24 hours after desoxymethasone, vaseline and hydrobase had been applied. Results : The recovery of TEWL was most prominantly observed in the desoxymethasone ointment treated group followed by vaseline and hydrobase. Electron microscopic examination using ruthenium tetroxide fixation revealed that secretion and numbers of lamellar bodies and complete formatice of lipid bilayers were most prominent at desoxymethasone ointment and vaseline treated group. Conclusion : Desoxymethasone ointment, vaseline and hydrobase can be good agents in improving bamer recovery after exposure to irritant material. (Korean J Dermatol 1998;36(5): 820-826)
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