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      • 가토(家兎)의 신장기능(腎臟機能)에 미치는 측뇌실내(側腦室內) Prostaglandin $F_{2{\alpha}}$의 영향(影響)

        국영종,고광후,Kook, Young-Johng,Ko, Kwang-Hoo 대한약리학회 1976 대한약리학잡지 Vol.12 No.2

        The facts that $PGE_2$ produced diuresis in the rabbit when given into a lateral ventricle of the brain and that $PGF_{2{\alpha}}$ is abundantly found in the brain prompted us to investigate the effects of $PGF_{2{\alpha}}$ introduced directly into the ventricle on the renal function. $PGF_{2{\alpha}}$ given intraventriculary in doses of $10{\mu}g\;and\;100{\mu}g$ elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action. Atropine pretreatment did not influence the renal effects of intraventricular $PGF_{2{\alpha}}$. Intravenously administered $PGF_{2{\alpha}}$ in doses of 30 to $100{\mu}g$ did not produce any significant change in renal function. Intraventricular $PGF_{2{\alpha}}$ had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension. These observations suggest that $PGF_{2{\alpha}}$ induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that $PGF_{2{\alpha}}$ might play a roll in regulating renal function through the center.

      • 가토(家兎)의 신장기능(腎臟機能)에 미치는 측뇌실내(側腦室內) Prostaglandin F<sub>2α</sub>의 영향(影響)

        국영종(Young-Johng Kook),고광후(Kwang-Hoo Ko) 대한약리학회 1976 대한약리학잡지 Vol.12 No.2

        The facts that PGE<sub>2</sub> produced diuresis in the rabbit when given into a lateral ventricle of the brain and that PGE<sub>2α</sub> is abundantly found in the brain prompted us to investigate the effects of PGE<sub>2α</sub> introduced directly into the ventricle on the renal function. PGE<sub>2α</sub> given intraventriculary in doses of 10μg and 100μg elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action. Atropine pretreatment did not influence the renal effects of intraventricular PGE<sub>2α</sub>. Intravenously administered PGE<sub>2α</sub> in doses of 30 to 100μg did not produce any significant change in renal function. Intraventricular PGE<sub>2α</sub> had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension. These observations suggest that PGE<sub>2α</sub> induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that PGE<sub>2α</sub> might play a roll in regulating renal function through the center.

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        태권도 손날몸통막기 유형에 따른 메커니즘 비교분석

        신현무(HyunMooShin),고석곤(SukGonGo),강성철(SungChulKang),고광후(KwangHooKo),김태완(TaeWhanKim) 한국체육학회 2009 한국체육학회지 Vol.48 No.4

        본 연구의 목적은 국가대표 품새 시범단 선수들을 대상으로 3차원 영상분석(Vicon Camera 7대)과 지면반력기(AMTI 2대)를 이용하여 두 가지 유형의 태권도 손날몸통막기 동작의 특성들을 알아보고 두 유형의 차이를 검증하는데 있다. 분석 변인으로는 시간, 손날의 최대합성속도, 중심변인, 지면반력이 있다. 각 변인별 평균치와 표준편차를 구한 후, 두 가지 유형별로 종속 T test를 실시하여 그 차이를 분석하였으며 다음과 같은 결과를 얻었다. 지면반력 변인에서 좌·우 지면반력은 유형1이 유형2보다 좌우 지지발 모두에서 더 큰 지면반력값을 나타냈으며, 전·후 지면반력은 유형2가 유형1보다 좌우 지지발 모두에서 더 높은 값을 보였다. 수직 지면반력은 좌측 지지발에서는 유형1이, 우측 지지발에서는 유형2가 더 큰 지면반력값을 나타내었다. 전·후 지면반력(좌: p<.037 , 우: p<.004)과 상·하 지면반력(좌: p<.016, 우: p<.002)에서 통계적으로 유의한 차이를 나타내 보였다. The purpose of this study is to examine the kinetical and biomechanical characteristics of two types of double knife-hand body blocking movement and to verify the characteristic differences of the two types. For the experiment, 3D image analysis(Vicon camera 7) and ground reaction force plates(AMTI 2) are used and the subjects are selected from the Korean National Poomse Demonstration Team. The analysis variables are time, velocity, mid-point balance, and ground reaction force. Each variable’s mean and standard deviation is calculated and then a dependent T test is used to analyze the statistical differences between the two types. The results of the analysis are as follows: The Ground Reaction Force(GRF) of type1 is measured higher than that of type2 in the medio-lateral plane for both supporting feet, whereas the GRF of type2 is observed higher than that of type1 in the anteroposterior plane for both supporting feet. The vertical GRF shows that type1 is higher in left supporting foot, but type 2 is higher in right supporting foot. There are statistically significant differences for both supporting feet in the anteroposterior direction(left: p<.037, right: p<.004) and superior-inferior direction (left: p<.016, right: p<.002).

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