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Glycopyrrolate(Robinul)가 Scopolamine 의 서맥에 미치는 영향
정성수,정창영,하인호,하정성 대한마취과학회 1982 Korean Journal of Anesthesiology Vol.15 No.4
Glycopyrrolate, a synthetic quarternary ammonium compound, has a similar pharmacologic property to that of acopolamine, a belladonna alkaloid. Since glycopyrrolate, a quarternary ammonium compound, does not readily cross the blood brain barrier, it has less central effect than that of scopolamine, a tertiary-amine compound. The authors administered a small dose of scopolamine and glycopyrrolate to human volunteers, and examined the effect on the heart rate for both drugs. The results were as follows; 1) A small dose of scopolamine (0.1 mg) showed significant decrease in the heart rate. 2) A small dose of glycopyrrolate (0.1 mg) induced littel change in the heart rate. 3) A small dose of glycopyrrolate (0.1 mg), 10 minutes after glycopyrrolate (0.1 mg), showed marked increase in the heart rate. 4) A small dose of scopolamine (0.1 mg), given 10 minutes after glycopyrrolate (0.1 mg), showed tendency for decrease in heart kate. 5) A small dose of glycopyrrolate (0.1 mg), 10 minutes afterscopolamine (0.1 mg), showed significant increase in the heart rate. 6) Scopolamine induced bradycardia was suppressed by an additional dose of glycopyrrolate and a preceding dose of glycopyrrolate.
Clonidine 이 Midazolam 의 마취유도시간에 미치는 영향
정성수,하정성,박영옥 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.9
These studies were conducted to determine the influence of intravenous clonidine on the induction time of midazolam when used for induction of anesthesia and assoeiated hemodynamic effect. Eighty ASA physical status I or II patients were randomly allocated to one of four treatment groups ; normal saline (control, group 1, n=20), clonidine 1.25 ug/kg (group 2, n=20), clonidine 2.5 ug/kg (group 3, n=20), clonidine 5 ug/kg (group 4, n=20). The test drug was admi- nistered 15 min before induction of anesthesia with intravenous midazolam (0.23 mg/kg). After injection of midazolam, induction time (the time from the start of injection to spontaneous closing of eyes and to loss of eye-lash reflex) and apnea ratio were recorded as well as mean arterial pressure, heart rate and oxygen saturation at 3 min intervals up to induction of anesthesia and then at 1 min intervals for 10 min. Significant shortening in induction time were observed in clonidine groups (33±8 and 448 sec in group 2, 32±7 and 428 sec in group 3, 26 and 38±8 sec in group 4) compared with the control group (68±11, 83±11 sec in group 1), but there were no significant difference between clonidine groups. Mean arterial pressure and heart rate were significantly decreased by large dose of clonidine (group 3 and 4), but not changed by saline and small dose of clonidine (group 1 and 2). These results suggest that small dose (1.25 ㎍/kg) of clonidine shortened the induction time of midazolam and did not significantly affect the hemodynamics.
하정성 대한마취과학회 1975 Korean Journal of Anesthesiology Vol.8 No.1
It has been generally known that hypotension may occur during total hip prosthesis with general anesthesia. However, The cause of hypotension is not well known. In these cases, of total hip prosthesis during general anesthesia, the following results were obstained. 1) during total hip prosthesis, blood pressure fell. 2) intravenous injection of effortil and dexamethasone improved the hypotension.
나라장터 용역계약의 낙찰가율에 영향을 미치는 발주요인 분석
하정성(Jung-Sung Ha),최태홍(Tae-Hong Choi),조완섭(Wan-Sup Cho) 한국컴퓨터정보학회 2023 韓國컴퓨터情報學會論文誌 Vol.28 No.12
본 연구는 낙찰가율에 영향을 미치는 용역계약에 대한 요인을 나라장터의 사례를 중심으로 분석하는 것을 목적으로 한다. 연구에서 발주기관과 입찰자가 광범위한 나라장터에서 낙찰가율에 영향을 주는 용역계약을 분석함으로써 기존 연구와의 차별성을 살펴보았다. 분석모형으로 낙찰가율 영향 요인으로 예산액, 계약 방법, 공고 일수, 낙찰 방법, 낙찰 하한률 등 5개의 독립변수를 활용하였다. 조사분석은 지난 18년간 나라장터 용역입찰건에 대한 데이터를 텍스트 마이닝을 이용하여 빅데이터를 수집하고 다차원적인 방법으로 데이터를 분석하였다. 분석 결과 첫째, 예산액은 낙찰가율을 결정하지 않는다. 다만 소액의 경우에는 그러하지 아니하였다. 둘째, 계약 방법은 낙찰가율에 영향을 미치는 것으로 나타났다. 셋째, 공고 일수가 길어질수록 낙찰가율이 감소하고 있다. 넷째, 낙찰 방법은 낙찰가율에 영향을 미치고 있다. 다섯째, 낙찰 하한률은 낙찰가율을 결정하고 있다. 본 연구는 낙찰가율에 영향을 미치는 요인에 대한 실증분석 결과를 토대로 정책적 시사점을 찾고자 하였다. The purpose of this study is to analyze the factors for service contracts that affect the successful bid price rate, focusing on the case of the country market. In the study, ordering organizations and bidders differentiated themselves from existing studies by analyzing service contracts that affect the successful bid price rate in a wide range of country markets. Comparative analysis of the awarding price ratio for services, this work provides a comparable result to the existing results in the previous literature. The analytical model used five independent variables such as budget, contract method, the days of the public notice, the awarding method, and the lowest awarding ratio. In the survey and analysis, big data was collected using text mining for service bids for Nara Market over the past 18 years and data was analyzed in a multi-dimensional way. The results of the analysis are as follows, (1) if budget does not determine the awarding price ratio. This is not the case in small amounts. (2) The contract method affects the awarding price ratio. (3) The days of the public notice increase, the awarding price ratio decrease. (4) the awarding method affects the awarding price ratio. (5) The lowest awarding ratio determines the awarding price ratio. Based on the results of empirical analysis, policy implications were sought.
Ether 마취중 Atropine 및 Propantheline 이 심박수변화에 미치는 영향의 비교
하정성 대한마취과학회 1975 Korean Journal of Anesthesiology Vol.8 No.1
It has been generally understood that belladonna alkaloids in small doses produce bradyc- ardia. However, it is also known that these agents increase heart rate during general anest- hesia. In this study, a comparison of atropine and propantheline on human heart rate during ether anesthesia was made and the following results were obtained. 1) Atropine and propantheline increased heart rate. 2) Effect of propantheline on the heart rate was more marked than that of atropine.