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- 저자 : 愼鏞會 (검색결과 4 건)
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Ginsenoside Re와 Rg_1의 렛드 담췌액 분비 촉진 작용
愼鏞會,李範九,李善美,朴鍾大,趙台淳 성균관대학교 약학연구소 1994 成均藥硏論文集 Vol.6 No.1
The focus of this study was to investigate the influences of ginsenoside Re and Rg_1 on pancreaticobiliary secretion, cholate ouput and amylase activity. After single or two weeks administration of ginsenosides, pancreaticobiliary juice of rats was collected for 8hrs. No change was observed in pancreaticobiliary juice volume in single-treated rats compared to control, but this was significantly increased in two weeks-treated rats. While cholate output was increased in single-treated group as dose-dependent manner, it was significantly increased in two weeks-treated group. A marked increases of amylase activity in the pancreaticobiliary juice were observed in both single administration of Rg_1 and two weeks administration of ginsenoside.
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人蔘 Saponin成分이 흰쥐 膽膵液 分泌에 미치는 效果에 관한 硏究
愼鏞會,李炫實,朴鍾大,趙台淳 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2
The effect of saponins including water extract of Panax Ginseng was studied on the pancreaticobiliary secretion and cholate output and amylase activity in rats. The saponins tested were crude saponin, panaxadiol (PDS), panaxatriol (PTS). After single or two weeks administration of the samples, pancreaticobiliary juice of rats were collected for 8 hrs and the results obtained were summarized as follows. (1) In animals with single administration, pancreaticobiliary juice volume(PJV) was not significanty increased as compared to the control group. However, there was a significant increase in PJV of animals from 4 to 6 hrs after two weeks administration of water extract (500mg / kg / day) or crude saponin(50mg / kg / day). (2) Cholate output was increased dose-dependently from 1 to 5 hrs after the single administration of PDS, PTS. On the other hand, after two weeks administration of crude saponin (50mg/kg/day), the cholate output of the animals was increased significantly. (3) amylase activity in the juice were intermittently increased in single administration of water extract, crude saponin and PTS(100mg / kg). After two weeks administration, there was a significant increase in amylase activity of animals treated with PTS as compared to the control group.
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5-Phenyl-2, 4-Pentadienoic Acid Amide 유도체의 중추 억제작용에 관한 연구
조태순,임중기,신용회,신대희 대한약학회 1987 약학회지 Vol.31 No.1
In order to find out the pharmacologically active but less toxic compounds than piperine, the actions of several amide derivatives of 5-phenyl-2, 4-pentadienoic acid on the CNS depressant activities were examined. The nine amide derivatives were investigated by using ICR mice as an experimental amimals on acute toxicities, anticonvulsant, sedative, analgesic and antipyretic effects. In the case of acute toxicities, all derivatives were weaker than piperine except compound III. Compound I showed strong anticonvulsant activity. On the other hand, compound I, III and IV significantly prolonged the sleeping time induced by hexobarbital in mice. Compound I, III and IV exhibited better analgesic effect than aspirin while compound II, V, VII and IX showed similar antipyretic activity to aspirin.
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