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마우스에서 Candida albicans의 병원성에 관한 연구
전준열(Joon Yul Chon),김영표(Young Pio Kim) 대한피부과학회 1989 大韓皮膚科學會誌 Vol.27 No.4
In search for animal model of systemic candidiasis, the authors attempted to infect the mice with Candida albicans (CUMD 23 and CUMD 25) isolated from human subjeets and study the mode of infection and pathogenesis. Swiss mice were inoculated with these organisrns either intravenously or intraperitoneally. After deterrnining the lethal doses of the pathogens at 30th day, another group of mice were inoculated with a sublethal dose. They were sacrificed weekly up to 4 weeks and the organs were examined mycologically and histopathologically. The results show that strain CUMD 23 is more virulent than CUMD 25. The most susceptible organ to C. albicans is the kidney followed by the peritoneum, mesentery and the pancreas. In the early lesion, C. atbicans generally show the spore form in the peritoneum, mesentery and the kidney when injected intraperitonea,lly but as time went by it rather took the hyphal form especially in the kidney. In the case of intravenous injection, the hyphal masses were seen in the kidney more quickly. With this result, it is suggested that the dissemination of C. albicans occurs easily in the latter and the spores reaching the kidney transform into hyphae which are not easily subjected to phagocytosis.
사람피부조직의 adenosine deamonase 산소활성에 관한 연구
임철완,김영표,강정봉,전준열 대한피부과학회 1981 대한피부과학회지 Vol.19 No.4
Adenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and amrnonia, was assayed in human penile foreskin. The skin tissue was separated into two layers; epidermis and dermis. They were sliced with scissors into gel state, 4 volumes of 0. 05M phosphate buffer solution were added and the tissue homogenized. After centrifugation at 4,000xg for 5 minutes, the supernatant was used as an enzyme solution. ADA activity was measured according to the method of Giuseppe$quot; ADA was found to be present in both layers (epidermis; 0. 24 ΔOD/mg protein, dermis; 0. 19 ΔOD/mg protein) with slightly higher activity in the epidermis. As in earlier reports, it was found that ADA in the skin showed nearly even activity in the pH range of 5.0-8.0. Considering the significance of ADA in immunological function, the presence of ADA in the skin suggests that the tissue may participate in the immune function.