Association of Syntax Score II with Contrast-induced Nephropathy and Hemodialysis Requirement in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Ibrahim Rencuzogullari,Metin Çağdaş,Süleyman Karakoyun,Yavuz Karabağ,Mahmut Yesin,Mustafa Ozan Gürsoy,İnanç Artaç,Doğan İliş,Süleyman Çağan Efe,Kevser Tural,Ibrahim Halil Tanboğa 대한심장학회 2018 Korean Circulation Journal Vol.48 No.1

Background and Objectives Contrast-induced nephropathy (CIN) is a common complication of primary percutaneous coronary intervention (pPCI) and is associated with high mortality and morbidity and long hospital stay in patients with ST elevation myocardial infarction (STEMI). The Syntax Score (SS) has previously been studied in STEMI patients, and it was associated with increased CIN development and long-term mortality. This study investigates a possible relationship between CIN development and Syntax Score II (SSII) and compares SS and SSII by assessing CIN risk in STEMI patients treated with pPCI. Methods A total of 1,234 patients who underwent pPCI were divided into 2 groups according to CIN development. Patients with CIN were further divided into 2 groups according to whether or not they required hemodialysis. Reclassification tables, net reclassification improvement, and integrated discriminative improvement methods were used to assess the additive predictive value of SSII for predicting CIN. Results In the present study, 166 patients (13.5%) had CIN. Although both SS and SSII were significantly higher in CIN patients, only SSII was an independent predictor of CIN (odds ratio [OR], 1.031; 95% confidence interval [CI], 1.012–1.051; p<0.001) and hemodialysis requirement (OR, 1.078; 95% CI, 1.046–1.078; p<0.001). When comparing SSII and SS in their ability to determine CIN risk, we found SSII to have a reclassification improvement of 27.59% (p<0.001) and an integrated discrimination improvement of 9.1% (p<0.001). Conclusions The combination of clinical and anatomic variables can more accurately identify patients who are at high risk for CIN after pPCI. While SSII is harder to calculate than SS, it provides better prediction for CIN and hemodialysis requirement than SS.

The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Ibrahim Burak Atci,Hakan Yılmaz,Mustafa Yavuz Samanci,Aysel Gurcan Atci,Yesim Karagoz 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.2

Study Design: Retrospective case control. Purpose: The authors of this study assessed whether the prevalence of paraspinal fatty degeneration correlates with the presence of Modic type I and I/II change in patients with low back pain (LBP). Overview of Literature: Modic changes are bone marrow and end plate changes visible on magnetic resonance imaging. Methods: A consecutive series of 141 patients who attended the neurosurgery outpatient clinic between April 2017 and September 2017 for nonspecific LBP were evaluated. Sixty-one patients with single-level Modic type I or I/II change constituted the patient group. Eighty age-, gender-, and body mass index (BMI)-matched patients without any Modic changes were recruited as the control group. A retrospective review was performed in 61 patients with Modic changes and 80 controls without Modic changes. The percentage of fatty muscle degeneration was graded by two reviewers using T2-weighted axial images at the L4–L5 level. The system was graded as follows: grade 0, normal; grade I, minimal focal or linear fat deposition; grade II, up to 25%; grade III, 25%–50%; and grade IV, more than 50%. Results: Sixty-one patients with nonspecific LBP and Modic type I or I/II change and 80 patients without Modic changes were evaluated. There was no difference between these groups in terms of age, gender, and BMI distribution. The mean muscle cross-sectional area in the patient and control groups were 1,507.37±410.63 and 1,681.64±379.69. Regarding fatty degeneration, a chi-square test of homogeneity was run, and the two multinomial probability distributions were not equal within the population analyzed. Conclusions: The novel finding of this investigation is that patients with Modic type I and I/II changes have greater amounts of fatty degeneration in their lumbar paraspinal musculature.

Load Frequency Control of Single-Area Power System with PI–PD Controller Design for Performance Improvement

Güler Yavuz,Kaya Ibrahim 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4

Load frequency control (LFC) is an important control problem as it determines the quality of power generation by controlling the system frequency and inter-area tie-line power. To maintain a good quality power supply, LFC must be robust against unknown external disturbances and parameter variations of the power system. Therefore, this paper presents the design of PI–PD controllers, which are robust against parameter changes and have good disturbance suppression capability, for load frequency control of a single-area single- or multi-source power system. PI–PD controller parameters were obtained by applying the weighted geometric center method to the stability boundary locus of the closed-loop control system. The approach was applied to both the inner and outer loops of the PI–PD control system structure, sequentially. Performance and robustness of the proposed PI–PD control system are evaluated using some well-known integral error criteria values, settling time, and peak value (overshoot) in the analysis of the power system with both nominal values and ± 50% changes in the system parameters. The simulation results show that the designed PI–PD controller effectively limits the effect of load disturbance and variations in system parameters.

Three-dimensional assessment of nasal changes after maxillary advancement with impaction using stereophotogrammetry

Gokhan Cobana,Ibrahim Yavuz,Busra Karadas,Ahmet Emin Demirbas 대한치과교정학회 2020 대한치과교정학회지 Vol.50 No.4

Objective: To evaluate the changes in the nose in three dimensions after Le Fort I osteotomy in patients with skeletal Class III malocclusion. Methods: The subjects were 40 adult patients (20 females and 20 males; mean age, 20.3 ± 3.0 years; range, 17.0 to 31.1 years) who underwent one-piece Le Fort I osteotomy with maxillary advancement and impaction treatment for maxillary hypoplasia. The mean maxillary advancement was 4.56 ± 1.34 mm, and the mean maxillary impaction was 2.03 ± 1.04 mm. Stereophotogrammetry was used to acquire three-dimensional images before and at least 6 months after surgery. Results: Alare (Al) and alare curvature (Ac) points had moved vertically and anterolaterally postoperatively. A significant increase was observed in the nasal ala width and alar base width, and no changes were noted in the columellar length, nasolabial angle, and nasal area. There was a significant relationship between maxillary impaction and nasal ala width and horizontal and sagittal positions of the bilateral Al and Ac. The only relationship found was between maxillary advancement and postoperative sagittal location of the subnasale and pronasale. Conclusions: Nasal soft tissues were highly affected by the vertical movement of the maxilla; however, the soft tissue responses were individual-dependent.

Prostate Biopsy in the Elderly: Histologic Findings and Treatment Necessity

Akman, Ramazan Yavuz,Koseoglu, Hikmet,Oguzulgen, Ahmet Ibrahim,Sen, Erhan,Yaycioglu, Ozgur Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

The aim of this study is to determine results of high prostate specific antigen (PSA) or abnormal digital rectal examination driven prostate biopsies performed in our Department in men aged 75 or more and to show the characteristics of pathology results. The hospital records of the patients who had high PSA or abnormal digital rectal examination driven prostate biopsy in two common university based research hospitals have been reviewed retrospectively. Patients aged 75 years or older at the date of biopsy whose records provided pathology results and full medical history were evaluated for the study. A total of 103 patients were evaluated with a mean age of $79.4{\pm}3.4years$. More than half of the patients (55.1%) were in their seventh decade and the rest were in the eighth decade. Median PSA value was 15.0 (range 2.1-4500) ng/ml. In most of the biopsies (67%), PSA levels were lower than 20 ng/ml. In almost half of the patients (48%), digital rectal examination was abnormal. In 68.9% of the patients, there were at least one or more associated co-morbid diseases. Gleason scores were 7 or higher in 73%, and 8 or higher in 37% of the patients with prostate cancer. Four of the 70 (6%) patients had bone metastases. Castrations were applied to most of the patients with prostate adenocarcinoma (%79). High percentage of high grade (Gleason 7 or more) prostate adenocarcinoma in the elderly refutes the perception of prostate cancer in this age group as clinically insignificant. Therefore, it is to be kept in mind that prostate cancer in the elderly an be clinically significant and prostate biopsies are to be performed when necessary.

Maxillary expansion with the memory screw: a preliminary investigation

Halicioglu, Koray,Kiki, Ali,Yavuz, Ibrahim The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.2

Objective: The purpose of this study was to investigate the effects of a newly developed rapid maxillary expansion screw-the memory screw-over 6 months. Methods: Five subjects, aged between 11.7 and 13.75 years, were enrolled in this study. All subjects underwent placement of a maxillary expansion appliance containing superelastic nickel-titanium open-coil springs in its screw bed. The parents of the patients and/or the patients themselves were instructed to activate the expansion screw by 2 quarter-turns 3 times a day (morning, midday, and evening; 6 quarter-turns a day). The mean expansion period was $7.52{\pm}1.04$ days. Dentoskeletal effects of the procedure, including dentoalveolar inclination, were evaluated. Measurements of all the parameters were repeated after 6 months of retention in order to check for relapse. Results: Sella-Nasion-A point (SNA) and Sella-Nasion/Gonion-Menton angles increased, and Sella-Nasion-B point (SNB) angle decreased in all the subjects during the expansion phase. However, they approximated to the initial values at the end of 6 months. On the other hand, the increments in maxillary apical base (Mxr-Mxl) and intermolar widths was quite stable. As expected, some amount of dentoalveolar tipping was observed. Conclusions: The newly developed memory expansion screw offers advantages of both rapid and slow expansion procedures. It widens the midpalatal suture and expands the maxilla with relatively lighter forces and within a short time. In addition, the resultant increments in the maxillary apical base and intermolar width remained quite stable even aft er 6 months of retention.

Internalized Stigma in Pediatric Psoriasis: A Comparative Multicenter Study

( Erkan Alpsoy Mualla Polat ),( Ibrahim Halil Yavuz ),( Pelin Kartal ),( Didem Didar Balci ),( Ayse Serap Karadag ),( Asli Bilgic Ercan Arca ),( Bilge Fettahlioglu Karaman ),( Selma Emre ),( Esra Adis 대한피부과학회 2020 Annals of Dermatology Vol.32 No.3

Background: Internalized stigma, adoption of negative attitudes and stereotypes of the society regarding persons’ illness, has not been studied previously in pediatric psoriasis patients. Objective: We aimed to investigate the internalized stigma in pediatric psoriasis patients and to determine differences according to factors affecting internalized stigma compared to adult psoriasis patients. Methods: This multicenter, cross-sectional, comparative study included 125 pediatric (55 female, 70 male; mean age±standard deviation [SD], 14.59±2.87 years) and 1,235 adult psoriasis patients (577 female, 658 male; mean age±SD, 43.3±13.7 years). Psoriasis Internalized Stigma Scale (PISS), Dermatology Life Quality Index (DLQI), Perceived Health Status (PHS), and the General Health Questionnaire (GHQ)-12 were the scales used in the study. Results: The mean PISS was 58.48±14.9 in pediatric group. When PISS subscales of groups were compared, the pediatric group had significantly higher stigma resistance (p=0.01) whereas adult group had higher scores of alienation (p=0.01) and stereotype endorsement (p=0.04). There was a strong correlation between mean values of PISS and DLQI (r=0.423, p=0.001). High internalized stigma scores had no relation to either the severity or localization of disease in pediatric group. However, poor PHS (p=0.007) and low-income levels (p=0.03) in both groups, and body mass index (r=0.181, p=0.04) in the pediatric group were related to high PISS scores. Conclusion: Internalized stigma in pediatric patients is as high as adults and is related to poor quality of life, general health, and psychological illnesses. Unlike adults, internalized stigma was mainly determined by psoriasis per se, rather than disease severity or involvement of visible body parts, genitalia or folds. (Ann Dermatol 32(3) 181∼188, 2020)

TEMPO-treated CNF Composites: Pulp and Matrix Effect

Bayram Poyraz,Ayhan Tozluoğlu,Zeki Candan,Ahmet Demir,Mustafa Yavuz,Ümit Büyuksarı,H. İbrahim Ünal,Hakan Fidan,Rasim Cem Saka 한국섬유공학회 2018 Fibers and polymers Vol.19 No.1

This study examined the effects of matrix (PVA and Si) on the properties of TEMPO-treated nanocomposites preparing from different pulp sources (Kraft and NaBH4 treated Kraft). Chemical characterization and crystallization were determined via FT-IR, thermal stability via TGA and morphological alterations via SEM. UTM and DTMA were used to measure the Young’s and storage moduli. The real and imaginary parts of permittivity and electric modulus were evaluatedusing an impedance analyzer. After interaction, prominent vibrations and alteration of crystallinity were seen. Storage and Young’s moduli decreased after Si and PVA interaction. The Si-TOCN films showed higher permittivity properties and all of the films followed a similar trend of significantly dropping ε' and ε'' values at high frequency. The PVA-TOCN films had mechanical advantages at room temperature compared to the Si-TOCN films. However, the Si-TOCN films had better thermomechanical properties at high temperatures. NaBH4 revealed favorable effects on mechanical properties of the films.

Effects of Al on the Phase Volume Fractions and Wear Properties in the AlxCoCrFeMoNi High Entropy Alloy System

Hakan Gasan,Ersu Lökçü,Akin Ozcan,Osman Nuri Celik,Ibrahim Celikyurek,Mustafa Ulutan,Yavuz Kurtulus 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.3

A detailed investigation was carried out to study the effect of Al on the phase volume fractions and wear properties in theAlxCoCrFeMoNihigh entropy alloy (HEA) system. The analysis of phases was studied by X-ray diffraction for further Rietveldrefinement was performed to determine the volume fraction of phases. In order to accomplish experimental studies, thevolume fraction of phases has been analyzed by CALPHAD based simulations. The wear behavior of HEAs were studiedunder dry sliding conditions using a ball-on-disc geometry. The alloy system includes FCC, σ, B2 and BCC phases andexhibits a broad range of phase transformations with varying Al content. The wear behavior of HEAs, in the present work, iscorrelated with their volume fraction of phases and hardnesses. The minimum wear rate, 3.04 × 10−5 mm3/(Nm), is observedin A1.5CoCrFeMoNialloy containing relatively hard σ, B2 and BCC phases, which has a maximum hardness 829.8 HV.

Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis?

Bahar Bektan Kanat,Gulru Ulugerger Avci,Osman Faruk Bayramlar,Damla Unal,Ozge Sonmez,Ibrahim Murat Bolayirli,Alper Doventas,Deniz Suna Erdincler,Hakan Yavuzer 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.2

Background: Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs). We investigated the use of MMP2/TIMP2 and MMP9/TIMP1 ratios as biomarkers of bone resorption in geriatric osteoporosis and evaluated the relationship between osteoporosis and geriatric syndromes. Methods: This analytical cross-sectional study involved 87 patients (41 with osteoporosis) treated at the geriatric outpatient clinic of a university hospital. The demographic characteristics, comprehensive geriatric assessment scores, laboratory findings, and bone mineral density of the patients were recorded. Serum MMP9, TIMP1, MMP2, and TIMP2 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: We enrolled 41 and 46 patients with and without osteoporosis, respectively. The groups showed no significant differences in MMP2/TIMP2 and MMP9/TIMP1 ratios (p=0.569 and p=0125, respectively). While the basic activities of daily life (BADL) scores in the osteoporosis group were higher than those in the group without osteoporosis, the instrumental activities of daily life (IADL) scores were significantly lower (p=0.001 and p=0.007, respectively). No significant differences were observed in Mini-Nutritional Assessment, Mini-Mental State Examination, and Geriatric Depression Scale scores (p=0.598, p=0.898, and p=0.287, respectively). Conclusion: This is the first study to examine the relationship between osteoporosis and several geriatric syndromes, as well as the relationship between osteoporosis and serum MMP, TIMP values, and MMP/TIMP ratios in geriatric patients. Our results showed that osteoporosis causes dependency in both BADLs and IADLs, and that the MMP2/TIMP2 and MMP9/TIMP1 ratios provided no additional benefit in demonstrating bone resorption in geriatric osteoporosis.