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Heat transfer and thermal error analysis of micro - macro coaxial driver
Hai Shun Deng,Yongtao Wang,Tian Xie,Bo Xu,Sen Huang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10
In order to reduce the influence of temperature on the operating performance of the macro and micro drive, a double-wounding circulating water cooling structure is proposed. Based on the law of thermal resistance, the heat transfer model of the macro and micro drive forced convec-tion cooling was established, and the influencing factors of the internal temperature distribution of the macro and micro drive system were analyzed. And the macro to micro drive forced con-vection cooling when the macro dynamic system part of the output force, and the size of the output displacement and micro system of the rise of temperature of the giant magnetostrictive material (GMM) and output displacement simulation and experiment, the results show that when the circulating water flow rate is more than 3 m/s, macro to micro drive internal temperature decreased significantly, the macro dynamic range at around 1 N. The fluctuation range of macrodynamic output displacement is between 0~20 μm. The error of output displacement gen-erated by the micro-motion magnetostrictive rod is less than 1 μm, at this time, the temperature change has little influence on the output force, output displacement and micro output displace-ment of the macro-moving part.
Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis
Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.