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        Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae

        Sawada Yuta,Takahashi Shinji,Terai Hidetomi,Kato Minori,Toyoda Hiromitsu,Suzuki Akinobu,Tamai Koji,Yabu Akito,Iwamae Masayoshi,Nakamura Hiroaki 대한척추외과학회 2024 Asian Spine Journal Vol.18 No.1

        Study Design: Level 3 retrospective cohort case-control study.Purpose: This study aimed to investigate the risk factors for distal junctional kyphosis (DJK) caused by osteoporotic vertebral fractures following spinal reconstruction surgery, with a focus on the sagittal stable vertebra.Overview of Literature: Despite the rarity of reports on DJK in this setting, DJK was reported to reduce when the lower instrumented vertebra (LIV) was extended to the sagittal stable vertebra in the posterior corrective fixation for Scheuermann’s disease.Methods: This study included 46 patients who underwent spinal reconstruction surgery for thoracolumbar osteoporotic vertebral fractures and kyphosis and were followed up for 1 year postoperatively. DJK was defined as an advanced kyphosis angle >10° between the LIV and one lower vertebra. The patients were divided into groups with and without DJK. The risk factors of the two groups, such as patient background, surgery-related factors, radiographic parameters, and clinical outcomes, were analyzed.Results: The DJK and non-DJK groups included 14 and 32 patients, respectively, without significant differences in patient background. Those with instability in the distal adjacent LIV disc had a significantly higher risk of DJK occurrence (28.6% vs. 3.2%, <i>p</i>=0.027). DJK occurrence significantly increased in those with the sagittal stable vertebra not included in the fixation range (57.1% vs. 18.8%, <i>p</i>=0.020). Other preoperative radiographic parameters were not significantly different. Instability in the distal adjacent LIV disc (adjusted odds ratio, 14.50; <i>p</i>=0.029) and the exclusion of the sagittal stable vertebra from the fixation range (adjusted odds ratio, 5.29; <i>p</i>=0.020) were significant risk factors for DJK occurrence.Conclusions: Regarding spinal reconstruction surgery in patients with osteoporotic vertebral fractures, instability in the distal adjacent LIV disc and the exclusion of the sagittal stable vertebra from the fixation range were risk factors for DJK occurrence in the short term.

      • A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

        Kochi, Yuta,Yamada, Ryo,Suzuki, Akari,Harley, John B,Shirasawa, Senji,Sawada, Tetsuji,Bae, Sang-Cheol,Tokuhiro, Shinya,Chang, Xiaotian,Sekine, Akihiro,Takahashi, Atsushi,Tsunoda, Tatsuhiko,Ohnishi, Yo Nature Publishing Group 2005 Nature genetics Vol.37 No.5

        Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.

      • Field Scene Recognition for Navigating Autonomous Agricultural Vehicle

        ( Yoshinari Morio ),( Yuta Sawada ),( Masataka Shioji ),( Motoki Tanaka ),( Katsusuke Murakami ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        In this study, four agricultural vehicle navigation systems, namely, two different types of vehicle position estimation systems for self-localization of an autonomous agricultural vehicle, an obstacle detection system for safety self-driving, and an agricultural key-objects recognition system for intelligent worker assistance, were developed by using image processing system without using GNSS and LiDAR. Firstly, in the two types of vehicle position estimation systems, the position of a vehicle could be estimated by matching an input field scene image to the training scene images captured along each of targeted traveling routes. The scene images were captured by using a three-camera-type of capture system with left camera, front camera, and right camera. Secondly, in the obstacle detection system, obstacles on a road, ditches along a road, and the level difference between a traveling road and a farm field were detected by using the stereo camera built with two web camera. The obstacles, ditches, and the level difference were recognized by in real time estimating 3D ground plane. Finally, in the agricultural key-objects recognition system, key-object types(workers, trucks, containers, agricultural machines) and key-posture types(standing, squat, stoop, sitting), key-worker-direction types (front, back, left, right), and container contents amount could be recognized by using deep learning based system of YOLO. The experimental results demonstrated the potential of our systems for navigating an autonomous vehicle in agricultural fields.

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        Surgical Outcomes of Multilevel Posterior Lumbar Interbody Fusion versus Lateral Lumbar Interbody Fusion for the Correction of Adult Spinal Deformity: A Comparative Clinical Study

        Iwamae Masayoshi,Matsumura Akira,Namikawa Takashi,Kato Minori,Hori Yusuke,Yabu Akito,Sawada Yuta,Noriaki Hidaka,Nakamura Hiroaki 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.4

        Study Design: A retrospective case control study.Purpose: The purpose of this study was to compare the surgical outcomes of multilevel lateral lumbar interbody fusion (LIF) and multilevel posterior lumbar interbody fusion (PLIF) in the surgical treatment of adult spinal deformity (ASD) and to evaluate the sagittal plane correction by combining LIF with posterior-column osteotomy (PCO).Overview of Literature: The surgical outcomes between multilevel LIF and multilevel PLIF in ASD patients remain unclear.Methods: We retrospectively reviewed 31 ASD patients who underwent multilevel LIF combined with PCO (LIF group, n=14) or multilevel PLIF (PLIF group, n=17) and with a minimum 2-year follow-up. In the comparison between LIF and PLIF groups, their mean age at surgery was 69.4 vs. 61.8 years while the mean follow-up period was 29.2 vs. 59.3 months. We evaluated the transition of pelvic incidence–lumbar lordosis (PI–LL) and disc angle (DA) in the LIF group, in fulcrum backward bending (FBB), after LIF and after posterior spinal fusion (PSF) with PCO. The spinopelvic radiographic parameters were compared between LIF and PLIF groups.Results: Compared with the PLIF group, the LIF group had less blood loss and comparable surgical outcomes with respect to radiographic data, health-related quality of life scores and surgical time. In the LIF group, the mean DA and PI–LL were unchanged after LIF (DA, 5.8°; PI–LL, 15°) compared with the values using FBB (DA, 4.3°; PI–LL, 15°) and improved significantly after PSF with PCO (DA, 8.1°; PI–LL, 0°).Conclusions: In the surgical treatment of ASD, multilevel LIF is less invasive than multilevel PLIF and combination of LIF and PCO would be necessary for optimal sagittal correction in patients with rigid deformity.

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