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- 저자 : ( Yuko Teraoka ) (검색결과 1 건)
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( Yuko Teraoka ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Progesterone (P4) plays an important role in maintaining pregnancy via its anti-inflammatory effect in the myometrium: however, this effect is less understood in the fetal membrane. We previously reported that mice with dental Porphyromonas gingivalis (P.g ) infection could be useful as a model of preterm birth. In this model, inflammation in the fetal membrane via toll-like receptor 2 (TLR2) is thought to result in preterm birth. We investigated whether P4 prevented preterm birth and the effects of P4 in the fetal membrane in this preterm birth model. Methods: P.g mice were injected subcutaneously with (P.g +P4 mice) or without (P.g mice) 1 mg of P4 daily at days 15.5 to 17.5 of gestation. We observed the mice in these gestational periods. Western blot analysis was performed for detection of TLR2, NF-κB and MAPK in the fetal membrane at day 18 of gestation. We also evaluated inflammatory cytokines (IL-1β, IL-8, TNF-α) and the expression level of TLR2 at the same tissues using RT-PCR. Results: The average gestational period was 20.4 days in P.g +P4 mice and 18.3 days in P.g mice. The enhancement of NF-κB and MAPK expression levels was significantly decreased in P.g +P4 mice, compared with in P.g mice. Treatment with P4 reduced the enhancement of the expression of IL-1β, IL-8, and TNF-α; by 88%, 76% and 59%, respectively. And the enhancement of TLR2 expression was also decreased in P.g +P4 mice. Conclusion: P4 suppressed the activation of inflammatory signaling pathways via TLR2 in the fetal membrane of a chronic inflammation-induced preterm birth mouse model. The anti-inflammatory effect of P4 in the fetal membrane prevented preterm birth.
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