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A case of generalized pustular psoriasis of pregnancy
( Jimin Yun ),( Youngwook Ryoo ),( Hyunwook Kim ),( Sungae Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Generalized pustular psoriasis of pregnancy (GPPP) is a rare form of generalized pustular psoriasis that typically occurs in the third trimester of pregnancy. It is characterized by widespread coalescent sterile pustules and erythematous patches with systemic symptoms such as fever. Generalized pustular psoriasis of pregnancy (GPPP) may be confused with acute generalized exanthematous pustulosis (AGEP), which has similar clinical and histologic features. A 33-year old multigravida woman at 18 weeks of gestation presented with erythematous patches and pustules visited our clinic. She had history of systemic lupus erythematosus for a month and was taking a dose of hydroxychloroquine, aspirin and oral iron. The skin biopsy findings showed subepidermal bullous lesion containing neutrophils and upper dermal neutrophilic infiltrate. Under the suspicion of AGEP, she stopped her medicine and was treated with anti-histamine, systemic and topical steroid, but without improvement. Another skin biopsy was done and she was re-diagnosed as GPPP. Skin lesions improved after treatment with systemic cyclosporine and her symptoms resolved after delivery. We herein present an educational case of GPPP that misdiagnosed as AGEP.
[P110] A case of Secretan`s syndrome mimicking cellulitis
( Jinwoong Jung ),( Youngwook Ryoo ),( Byungho Oh ),( Sungae Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Secretan`s syndrome was first described by Henri-Francois Secretan in 1901, characterized by recurring, firm edema on the dorsum of the hand and rarely on the feet. The etiology, pathology, and treatment are not yet clear, but it is known to occur after repeated minor trauma such as contact with a hard object. For treatment, movement should be minimized by splinting or fixing with a plaster cast, and if there is movement disorder due to swelling, occupational therapy is needed. These conservative treatments often improve symptoms within a few weeks, but may require surgical intervention if symptoms persist or are accompanied by movement disorders or pain. We report a case of secretan`s syndrome on the left hand dorsum which is the first report in Korea.
[FCT 5] Three cases of cytopenia in patients during the azathioprine treatment for bullous disease
( Jinwoong Jung ),( Byungho Oh ),( Youngwook Ryoo ),( Sungae Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Azathioprine is an immunosuppressive drug that has been widely used in dermatology for the treatment of immunobullous diseases. Myelosuppression is the most important side effect that requires close observation of complete blood cell count. The clinical findings of myelosuppression include general weakness, poor oral intake, nausea, dyspnea and pallor. It can occur within several weeks to years after initial azathioprine treatment, so doing weekly full blood count for the first 4 weeks, followed by reduced frequency of monitoring to a minimum of once every 3 months is recommended. If the myelosuppression is not treated properly, it can cause fever, secondary infection, sepsis, even death. Herein, we present these 3 cases that are educational for dermatologists to keep in mind the risk of myelosuppression during azathioprine treatment.