Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

딤플을 적용한 평판에 대한 항력 감소 연구

백부근(Bu-Geun Paik),편영식(Young-Sik Pyun),김준형(Jun-Hyung Kim),김경열(Kyung-Youl Kim),김기섭(Kim1 ?Ki-Sup),정철민(Chul-Min Jung),김찬기(Chan-Ki Kim) 대한조선학회 2012 大韓造船學會 論文集 Vol.49 No.4

연구개발비가 기업성과에 미치는 영향에 관한 연구

김흥기,송영렬 한국세무회계학회 2004 세무회계연구 Vol.14 No.-

본 연구의 목적은 투자자에게 공시된 연구개발비 지출액 관련 회계정보가 기업성과에 미치는 영향을 알아보는 것이다. 이와 같은 연구의 목적을 수행하기 위해 우리나라 상장기업들 중 화학, 전기전자, 기계, 그리고 의약품업종에 속하는 78개 기업을 표본으로 선정하여 가설검증을 실시하였으며, 그 연구결과는 다음과 같다. 첫째, 당기의 연구개발비는 기업의 성과와 특별한 관계를 보여주지 못하였다. 하지만, 과거의 연구개발비 수준이 높을수록 주식투자수익률과 회계이익인 총자산순이익률이 높아지는 것으로 측정되었다. 따라서 당기의 연구개발비는 기업성과와 관계가 없다고 할 수 있으나 과거의 연구개발비는 그 규모가 클수록 기업성과가 높아진다고 할 수 있다. 둘째, 연구개발비의 비재무적 자료인 연구소설립경과기간이 길수록 그리고 연구원의 수가 많을수록 주식투자수익률이 높아지는 것으로 측정되었다. 그리고 연구원의 수와 회계이익간에도 연구원의 수가 많을수록 회계이익이 상승한다고 할 수 있다. 따라서 당기의 연구개발비와 당기의 기업성과간에는 특정한 관계가 발견되지 않았으나 과거의 연구개발비를 당기 기업의 매출이나 수익의 증대에 영향을 미치고 있는 것으로 판단된다.

백반증 환자의 혈청이 배양된 정상 인체 멜라닌 세포의 세포고사에 미치는 영향에 관한 연구

김민영,이성열,박영립,이종석,황규왕 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

About the etiologies of vitiligo, so many hypotheses have been proposed, but the exact pathologic mechanism was not clear. Among those hypotheses, autoimmune theory is most popular and clinically it is often accompanied by many other autoimmune disorders such as thyroid disease, pernicious anemia, diabetes mellitus, Addison's disease, autoimmune hypoparathyroidism and organ specific antibodies. Investigator thought that apoptosis is important mechanism on the destruction of melanocyte by autoantibodies. To prove this, 10 autoimmune disorder-free, active and progressive vitiligo patient's sera were added to melanocytes culture media and incubated for 48 hours. After that, investigator observed the changes of melanocyte with TUNEL stain and Hoechst stain, which were well-known methods for apoptotic cell stain. The melanocytes incubated with vitiligo patients sera showed more apoptosis than that with normal person's sera. These results indicates that vitiligo patients' sera have some substances inducing apoptosis of melanocytes.

물리치료사들의 대체의료에 관한 인식도 조사

김영희,김기열,배주환,김상수,남철현 경산대학교 보건복지연구소 2000 保健福祉硏究 Vol.5 No.-

This study was conducted to examine physical therapists' awareness of alternative medicine and their treatment. 250 physical therapists who were working in Daegu were selected as subjects of this study. Data were collected from February 21, 2000 to March 31, 2000. The results of this study are summarized as follows. 1. Among 218 respondents, 72.7% of them directly experienced alternative medicine. According to general characteristics of the respondents, 79.0% of them who were in thirties had experiences in alternative medicine. 83.3% of the respondents who had worked for above twenty years experienced alternative medicine and 90.0% of the respondents who were working in Oriental medical clinics had experiences in it. 79.8% of the respondents who had been married experienced alternative medicine and 88.4% of them who were Buddhists had experience in it. 2. The sources of information on alternative medicine were newspapers and broadcast (22.9%), seminars of related associations (22.5%), and Books (20.0%). 3. The respondents experienced alternative medicine for the purpose of treating their chronic diseases (67.0%), improving their energy and quality of life (20.5%), and improving their weak physical constitution (13.4%). 4. According to the respondents' trust in alternative medicine, 40.8% of them trusted chiropractic, while 25.2% of them trusted massage and finger-pressure therapy. 19.7% of them trusted taping therapy and 15.1% of them trusted sports massage. 5. 67.0% of the respondents treated patients by alter native medicine in the hospitals and clinics. In the case of treatment methods by alternative medicine, 35.3% of them gave patients the massage and finger-pressure. 33.0% of them adopted taping therapy and 24.3% of them tried to treat patients by chiropractic. 17.0% of them applied moxacautery, while 15.1% of them gave patients the sports massage. 6. The respondents adopted alternative medicine to treat following diseases: lumbago (57.5%), shoulder pain (51.8%), sciatica (39.9%), arthritis (36.2%), headache (31.1%), hypertension (24.3%), diseases of the peripheral nervous system (22.4%), diseases of digestive organ (14.6%), insomnia (12.3%), obesity (8.7%), stroke (5.5%), allergy and skin diseases (4.1%), cystitis (3.6%). 7. According to their motives of concern about alternative medicine, 59.1% of them were interested in it because they expected additional effect which could be obtained from it in parallel with Western medicine. 16.7% of them were concerned about alternative medicine because they lacked ability to solve patients' clinical problems, while 15.3% of them were interested in it because they acknowledged the effect of it. 8.9% of them had interest in alternative medicine because they were dissatisfied with medical and scientific approach of Western medicine. 8. 73.4% of the respondents thought that alternative medicine needed to be introduced in the college/university curriculum

의료 폐기물의 처리에 관한 연구

김용수,배성렬,김영채,박우용,공성호 한양대학교 에너지 ·환경기술연구소 1995 에너지·環境技術論文集 Vol.2 No.-

의료기관의 증가에 따라서 발생되는 폐기물의 증가 또한 매우 심각한 형편이다. 하지만 우리나라에서는 아직 의료 폐기물의 법적인 규제나 처리기술의 개발이 매우 미흡한 상태이다. 의료 폐기물은 일반적으로 일반 폐기물과 감염성 폐기물로 나뉘며 특히 감염성 폐기물은 발생 후부터 일반 폐기물과 분리하여 수거, 운반, 보관 및 처리하는 것이 매우 중요하다. 발생된 감염성 의료 폐기물은 일반적으로 멸균을 거쳐야 하며 최종적으로 회전식 소각로, 공기 조정식 소각로 또는 로타리킬른 등이 소각로를 이용, 소각처리 후 최종처리를 하도록 한다. 이에 따라 대기오염 방지시설 또한 적절히 설치·운영되도록 한다. Due to increasing numbers of medical facilities, wastes regarding medical activities are also increasing recently medical wastes are generally categorized an infectious wastes and non-infectious wastes. Infectious medical wastes should be separated from non-infectious wasted right after generation. A sterilization process should be applied before further treatment of infectious wastes. An incineration process is usually used for final treatment of wastes. Therefore, air pollution control devices are carefully designed for incinerators.

악하부에 발생한 결핵성 경부 임파선염

김영운,정숭룡,이승호,이종호,김창룡,박문성,류선열 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.4

Tuberculosis, a chronic infectious granulomatous disease, is preumed to be quite a rare entity. Because of the development of chemotherapy and the improvement of nutritional conditions, incidence of tuberculosis have reduced. For these reasons, tuberculosis may be overlooked in the differential diagnosis whenever dealing with a submandibular swelling. Diagnosis of tuberculous lymphadenitis consists of historical data, physical findings, laboratory tests and histologic examination. The treatment of choice seems to be surgical excision and long term antituberculosis chemotherapy. Surgery provides a rapid tissue diagnosis, because the histological examination of the excisional biopsy is the most reliable diagnostic test. This is the report of a case of tuberculous cervical lymphadenitis on left submandibular area with no evidence of the involvement of lung.

자산재평가제도의 평가와 정책방향에 관한 연구

金永旭,徐熙烈 강남대학교 사회과학연구소 1998 사회과학논총 Vol.5 No.-

DL-8280(Tarivie^(�), Ofloxacin)의 호흡기감염증에 대한 임상효과

김영환,김의종,김건열 최신의학사 1986 最新醫學 Vol.29 No.7

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.