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Tetracycline-incorporated Silk Fibroin Films
( Jong Ho Kim ),( Bong Seob Shin ),( Jong Young Jeon ),( Haeyong Kweon ),( You Young Jo2 ),( Heui Sam Lee ),( Kwang Gill Lee ) 한국잠사학회 2012 International Journal of Industrial Entomology Vol.25 No.1
Silk fibroin films incorporated with tetracycline was prepared and characterized by Fourier-transform infrared spectrometer and differential scanning calorimeter and examined antibacterial effect. The conformation of silk fibroin was changed from random coil to e sheet structure with incorporation of tetracycline. Antibacterial activity of the materials was evaluated against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus epidermis, and Staphylococcus aures) using agar plate method showing clear inhibition zone around tetracycline silk film. It is concluded that tetracycline-incorporated SF films are highly effective against bacteria.