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δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
He, Yongfeng,Ki, Hyunkyoung,Kim, Hangun,Kim, Kwonseop Published for the International Federation for Cel 2015 Cell biology international Vol.39 No.8
<P>δ-Catenin and β-catenin belong to different subfamilies of armadillo proteins but share some common binding partners, such as E-cadherin. This is the first study that demonstrated a novel common binding partner for δ-catenin and β-catenin, lymphoid enhancer factor-1 (LEF-1). We found that the N-terminus of δ-catenin (amino acids 85-325) bound to the middle region of LEF-1 unlike β-catenin. Overexpressed δ-catenin entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD-1 cell lines. The current study provided novel insights that will provide a better understanding of the effects of δ-catenin on Wnt/LEF-1-mediated transcriptional activity.</P>
( Yongfeng He ),( Hangun Kim ),( Taeyong Ryu ),( Youra Kang ),( Jeong Ae Kim ),( Bo Hyun Kim ),( Jae Hyuk Lee ),( Keonwook Kang ),( Qun Lu ),( Kwonseop Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
This study revealed that CWR22Rv-1 cells overexpressing δ-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, δ-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1α and vascular endothelial growth factor (VEGF) expression. Furthermore, δ-catenin overexpression was found to enhance nuclear distribution of both β-catenin and HIF-1α in hypoxic condition, which is diminished by knockdown of δ-catenin. Our current study adds novel evidence regarding contribution of δ-catenin to the progression of prostate cancer. ⓒ2012 Federation of European Biochemical Societies. Published by Elsevier B.v.All rights reserved.
Determination of C-Terminal 관-Catenin Responsible for Inducing Dendritic Morphogenesis.
Lee, Ho-Bin,He, Yongfeng,Yang, Gyeong-Su,Oh, Jin-A,Ha, Ji-Seon,Song, Oh-Hyuen,Lee, Do-Jin,Jung, Sang-Chul,Kim, Kyung Keun,Kim, Kwonseop,Kim, Hangun American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.8
<P>관-Catenin induces dendritic morphogenesis in several cells and it was reported that deletion of C-terminal 207 amino acid of 관-catenin completely abolished the dendritic morphogenesis. However, exact domain responsible for inducing dendritic morphogenesis in C-terminus of 관-catenin was not mapped. Here, we report that expression of ??C47 (lacking 47 amino acid of C-terminus: 1-1200), ??C77 (lacking 77 amino acid of C-terminus: 1-1170) deletion mutants of 관-catenin induced the dendritic morphogenesis of HEK293T and NIH3T3 cells as full-length 관-catenin did. In agreement with previous report, ??C207 deletion mutant did not show the dendritic morphogenesis of the cells. Interestingly, introducing 107 amino acid deletion of C-terminus (??C107 mutant: 1-1140) and 177 amino acid deletion of C-terminus (??C177 mutant: 1-1070) showed limited primary and secondary dendritic process and notable spine-like process formation. These results suggest that 1140-1170 amino acid of C-terminal 관-catenin is required for primary and secondary dendrite-like process formation.</P>