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조요한(Yo Han Joh),최인실(In Sil Choi),이근욱(Keun Wook Lee),오도연(Do Youn Oh),김병수(Byung Su Kim),이대호(Dae Ho Lee),김태유(Tae You Kim),방영주(Yung Jue Bang),우홍균(Hong Gyun Wu),성명훈(Myung Whun Sung),이철희(Chul Hee Lee),김광현(N 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2
Objective: The role of chemotherapy in locally advanced head and neck cancer has been established in nasopharynx and larynx as definitive therapy and organ preserving therapy, respectively. Oral cavity cancers are relatively uncommon and local recurrence is the main cause of treatment failure. We planned this retrospective study to evaluate the role of neoadjuvant chemotherapy in locally advanced oral cavity cancer patients. Materials and Methods: From 1988 March to 2001 February, locally advanced, previously untreated oral cavity cancer patients who received neoadjuvant chemotherapy were examined. Chemotherapy had been done in the following patients: Histologically proven squamous cell or poorly differentiated carcinoma, stage 3 or 4, and performance state 0-2 patients. Chemotherapy regimen consisted of cisplatin and infusional 5-fluorouracil. Response was evaluated after 2 cycles and in case of no response, definitive local therapy was done; otherwise 3 cycles was done before local treatment. Results: 48 patients were treated and 47 patients were evaluable for responses. Complete response rate was 6.4%(3/47) and partial response 80.0%(38/47), scoring overall response rate of 87.2%. Median time to progression was 27.0 months (95% CI : 0-58months) and overall 5 year survival was 54.8%. 5-year disease-free survival in the patients in remission after local treatment was 51.9%. In multivariate analysis, contributing factor to the survival were response to neoadjuvant chemotherapy and local treatment modalities. Extensive surgery was done in 10 patients and 25 patents (52.1%) was followed up with preserved function. With median follow-up of 57.0 months, 19 recurrences were detected, most of which were local or regional type. Conclusion: Neoadjuvant chemotherapy followed by local treatment in oral cavity cancer showed high response rate and was thought to be effective therapeutic approach especially in view of organ preservation.
Pontibacter salisaro sp. nov., Isolated from a Clay Tablet Solar Saltern in Korea
Joung, Yo-Chan,Kim, Han-Eul,Ahn, Tae-Seok,Joh, Ki-Seong 한국미생물학회 2011 The journal of microbiology Vol.49 No.2
A Gram-negative, aerobic, rod-shaped, and red-pigmented bacterial strain, $HMC5104^T$, was isolated from a solar saltern, found in Jeungdo, Republic of Korea ($34^{\circ}$59'47"N $126^{\circ}$10'02"E). The major fatty acids were summed feature 4 (comprising iso-$C_{17:1}$ I and/or anteiso-$C_{17:1}$ B; 37.2%), iso-$C_{15:0}$ (20.4%), and iso-$C_{17:0}$ 3OH (15.3%). The DNA G+C content was 46.0 mol%. The major isoprenoid quinone was menaquinone-7 (MK-7). A phylogenetic tree based on 16S rRNA gene sequences showed that strain $HMC5104^T$ formed a lineage within the genus Pontibacter, and was closely related to Pontibacter korlensis (95.9%), P. roseus (94.9%), and P. actiniarum (94.3%). Similarities to all other Pontibacter species were between 95.9-93.9%. On the basis of the evidence presented in this study, strain $HMC5104^T$ represents a novel species of the genus Pontibacter, for which the name Pontibacter salisaro sp. nov. is proposed. The type strain is $HMC5104^T$ (=KCTC $22712^T$ =NBRC $105731^T$).
김태용(Tae Yong Kim),조요한(Yo Han Joh),김진수(Jin Su Kim),홍용상(Yong Sang Hong),이근욱(Keun Wook Lee),윤탁(Tak Yun),송은기(Eun Ki Song),나임일(Im Il Na),신현춘(Hyun Chun Shin),김동완(Dong Wan Kim),이재서(Chae Seo RLee),성명훈(Myung W 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2
Background: About 3% of all cancer patients suffer from cancer of unknown primary origin. Generally, carcinoma of unknown primary (CUP) carries a grave prognosis, but primary tumor presented to the neck is exception to this. The aims of study are to determine the role of chemotherapy and to find the prognostic factors in unknown primary tumor presented to the neck. Method and Material: Eighty-four patients were diagnosed with unknown primary tumor presented to the neck between January 1996 and June 2002. Among 84 patients, 43 patients (52%) received chemotherapy, radiation or surgery were performed in 20 patients (23%), 21 patients (25%) had no treatment. Results: The response rates to chemotherapy were 87.5% in CUP only localized to the neck and 44.0% in CUP systemically involved (p=0.012). A median follow-up duration was 6.4 years and overall median survival time was 9 months. The median overall survival time of patients treated with chemotherapy were 17 months and that of patients who received surgery or radiation were 20 months (p=0.3548). The important prognostic factors were performance status and the number of involved organ. Conclusion: The prognosis of patients with CUP presented to the neck is more favorable than that of patients with CUP of other localization. The effectiveness of chemotherapy for CUP only localized to the neck was similar to that of surgery or radiation. The important prognostic factors were performance status and the number of involved organ.
서희선(Seo, Hee-Seon),조요한(Cho, Yo-Han),조치영(Joh, Chee-Young) 한국소음진동공학회 2007 한국소음진동공학회 논문집 Vol.17 No.9
A study was carried out to investigate the fluid-structure interaction phenomena of buried hydrophone system that exposed complex loads due to handling, transportation and installation. The buried hydrophone system has necessarily neighborhood structures for installation. Because of the neighborhood structure, acoustic field is deformed. We analyze the piezoelectric-structural-acoustic coupled problem and the results to use a finite element analysis software, ANSYS, which has an coupled field analysis capability. The effect of the component of hydrophone system is revealed altogether in pressure distribution. So, we classify and analyze the problem by four different compositions for decomposition.