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( Yeojung Koh ),( Jinkyung Cho ),( Donghyun Kim ),( Shinuk Kim ),( Hyun Sik Kang ) 한국체육학회 2015 전국체전기념 한국체육학회 학술발표회 Vol.2015 No.-
Purpose: The purpose of this study was to investigate the combined effect of caloric restriction and exercise training on non-alcoholic fatty liver disease (NAFLD) and its metabolic complication associated with high fat diet (HFD)-induced obesity. In this study, we attempted to delineate the potential mechanism(s) by which the combined treatment strategy improves the metabolic complications of NAFLD in HFD-induced obese mice. Method: C57BL/6 mice (n=50) were fed standard chow (SC) (n=10) or HFD (n=40) for 23 weeks. Further, the HFD fed mice were further divided into four groups; HFD (n=10), HFD+exercise training (EX, n=10), HFD+SC (n=10), and HFD+SC+EX (n=10) for the last 8 weeks of the 23-week dietary treatment period. Mice in EX groups were forced to run on a motor-driven rodent treadmill for 50 minutes per day and 5 days per week. Result: Liver histology showed that caloric restriction combined with treadmill exercise alleviated HFD-induced hepatic steatosis in conjunction with reduced body weight and subcutaneous fat mass gains and improved whole body insulin resistance. The beneficial effects of the treatments were associated with up-regulated molecular markers of hepatic β-oxidation in conjunction with suppressed molecular markers of de novo lipogenesis and inflammation. Yet, the alleviating effects of the treatments were in the order of HFD+SC+EX, HFD+SC, and HFD+EX. Conclusion: The current findings of the study suggest that caloric restriction combined with exercise training had greater treatment and/or protective effect against NAFLD and its metabolic complication in mice with HFD-induced NAFLD phenotype.