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RISS 인기검색어
- 검색키워드
- 저자 : ( Yehuda Ringel ) (검색결과 2 건)
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( Changhwan Choi ),( Tamar Ringel Kulka ),( Daniel Temas ),( Ari Kim ),( Yehuda Ringel ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Dysbiosis leading to abnormal intestinal fermentation has been suggested as a possible etiological mechanism in Irritable bowel syndrome (IBS). We aimed to investigate the location and magnitude of altered intestinal bacterial fermentation in IBS and its clinical subtypes. Methods: 114 IBS patients who satisfi ed Rome III criteria and 33 healthy controls (HC) were investigated. Intestinal fermentation was assessed using two surrogate measures: Intestinal intraluminal pH and fecal short chain fatty acids (SCFAs). Intraluminal pHs were measured at four quartiles (Q1-4) in each small and large bowel using a wireless motility capsule (SmartPill™). Fecal SCFAs including acetate, propionate, butyrate and lactate were analyzed by capillary gas chromatography. Correlations between intestinal pH, fecal SCFAs, intestinal transit time and IBS symptom scores were analyzed. Results: Intraluminal pH levels in Q1, Q4, and total colon were signifi cantly lower in IBS compared to those in HC (6.83 for IBS vs. 7.29 for HC, P = 0.042). There were no differences in total and segmental pH levels in the small bowel between IBS and HC (6.84 vs. 6.83, P = NS). The intraluminal colonic pH differences were consistent in all IBS subtypes. Total SCFAs level was signifi cantly lower in C-IBS than in D-IBS and M-IBS. The total SCFAs level in all IBS was similar with that in HC. Colonic pH levels correlated positively with colon transit time (CTT) and IBS symptom severities. Total SCFAs levels correlated negatively with CTT, and positively with stool frequency. Conclusions: Bacterial fermentation is increased in IBS across all subtypes compared with HC. The altered intestinal fermentation in IBS appeared to be in the colon but not in the small bowel. Fecal SCFAs negatively correlated with CTT and may not be a sensitive marker to estimate intraluminal bacterial fermentation.
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Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome
( Jackie D Wood ),( Su Mei Liu ),( Douglas A Drossman ),( Yehuda Ringel ),( William E Whitehead ) 대한소화기기능성질환·운동학회 (구 대한소화관운동학회) 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.1
Background/Aims Functional gastrointestinal disorders are those in which no abnormal metabolic or physical processes, which can account for the symptoms, can be identified. The irritable bowel syndrome (IBS) is a significant functional disorder, which affects 10-20 percent of the population worldwide. Predominant symptoms of IBS are abnormal defecation associated with abdominal pain, both of which may be exacerbated by psychogenic stress. Our study was designed to test a hypothesis that symptoms in a subset of patients with a diagnosis of IBS are associated with an autoimmune degenerative neuropathy in the enteric nervous system. Methods Serum was collected from Rome II-IBS patients and controls at the University of North Carolina Functional Gastrointestinal Diseases Center. Assay procedures were immunohistochemical localization of antibody binding to enteric neurons and human protein microarray assay for antigens recognized by antibodies in the sera. Results Eighty-seven percent of IBS sera and 59% of control sera contained anti-enteric neuronal antibodies. Antibody immunostaining was seen in the nucleus and cytoplasm of neurons in the enteric nervous system. Protein microarray analysis detected antibody reactivity for autoantigens in serum with anti-enteric neuronal antibodies and no reactivity for the same autoantigens in samples not containing anti-enteric neuronal antibodies in our immunostaining assay. Antibodies in sera from IBS patients recognized only 3 antigens out of an 8,000 immunoprotein array. The 3 antigens were: (1) a nondescript ribonucleoprotein (RNP-complex); (2) small nuclear ribonuclear polypeptide A; and (3) Ro-5,200 kDa. Conclusions Results of the present study suggest that symptoms in a subset of IBS patients might be a reflection of enteric neuronal dam - age or loss, caused by circulating anti-enteric autoimmune antibodies. (J Neurogastroenterol Motil 2012;18:78-85)
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