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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Oh, Chung Ryul,Kim, Jeong Eun,Kang, Jihoon,Kim, Sun Young,Kim, Kyu-pyo,Hong, Yong Sang,Lim, Seok-Byung,Yu, Chang Sik,Kim, Jin Cheon,Kim, Jihun,Jang, Se Jin,Kim, Tae Won Elsevier 2018 Clinical colorectal cancer Vol.17 No.4
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>We investigated whether the microsatellite instability (MSI) status affects the survival outcomes in patients with stage II/III rectal cancer who have undergone an upfront curative resection.</P> <P><B>Patients and Methods</B></P> <P>A total of 1103 patients with curatively resected stage II/III rectal cancer who had available polymerase chain reaction-based MSI results were included in the final analysis.</P> <P><B>Results</B></P> <P>Twenty-four (2.2%) patients in the total cohort were found to be MSI-high (MSI-H). In univariate analysis, neither disease-free survival (DFS) nor overall survival (OS) demonstrated significant differences between patients with MSI-H tumors and those with MSI-low (MSI-L) or microsatellite stable (MSS) tumors. The 5-year DFS rate was 78.0% in MSI-H patients and 69.9% in MSI-L/MSS patients (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.35-2.02; <I>P</I> = .689). The 5-year OS rates for MSI-H and MSI-L/MSS patients were 84.0% and 83.1%, respectively (HR, 0.86; 95% CI, 0.27-2.69; <I>P</I> = .790). By multivariate analysis, the MSI status did not affect either the DFS (HR, 1.00; 95% CI, 0.40-2.47; <I>P</I> = .994) or OS (HR, 0.85; 95% CI, 0.26-2.73; <I>P</I> = .778).</P> <P><B>Conclusions</B></P> <P>MSI-H tumors are rarely observed in rectal adenocarcinoma, and the MSI status may not affect the survival outcome in patients with a resected rectal cancer.</P>
Characterization of the autophosphorylating kinase, PkaF, in Streptomyces coelicolor A3(2) M130
Oh, Eun A.,Chi, Won-Jae,Kim, Mi-Soon,Kang, Sang Sun,Chun, Jaesun,Hong, Soon-Kwang Springer-Verlag 2011 Archives of microbiology Vol.193 No.12
<P>Streptomyces coelicolor, the model species for morphologically complex actinomycete bacteria, has unique characteristics such as morphological and physiological differentiation, which are controlled by various factors and several protein kinases. From the whole genomic sequence of S. coelicolor A3(2), 44 putative serine/threonine (Ser/Thr) protein kinases were identified, and the pkaF gene was chosen as the best-conserved protein for typical Ser/Thr protein kinases. pkaF encodes a 667-amino acid protein with a predicted N-terminal Ser/Thr kinase domain and four repeated C-terminal penicillin-binding domains and Ser/Thr kinase-associated (PASTA) domains. Based on PCR, a pkaF gene was cloned and heterologously expressed. PkaF expressed in Escherichia coli had the bigger molecular size than the expected value (75 kDa) and was further purified by Ni2+-NTA agarose affinity column chromatography to homogeneity. The purified PkaF was autophosphorylated through the transfer of the gamma-phosphate group of ATP. The extent of phosphorylation was proportional to the amount of PkaF, and the phospho-PkaF was dephosphorylated by the addition of the cell lysate of S. coelicolor A3(2). Although no change was observed in the pkaF disruptant, overexpression of pkaF induced severe repression of morphogenesis and actinorhodin production, but not undecylprodigiosin production, implying that PkaF specifically regulates morphogenesis and actinorhodin production in S. coelicolor.</P>
Supervoxel-based Staircase Detection from Range Data
Oh, Ki-Won,Choi, Kang-Sun The Institute of Electronics and Information Engin 2015 IEIE Transactions on Smart Processing & Computing Vol.4 No.6
In this paper, we propose a supervoxel clustering-based staircase extraction algorithm to obtain poses and dimensions of staircases from a point cloud. In order to effectively reduce the candidate points and accelerate supervoxel clustering, large planes in the scene, such as walls, floors, and ceilings, are eliminated while scanning the environment. Next, staircase candidates with small planes are initially estimated using supervoxel clustering. Then, parameter values for the staircases are refined, and higher staircases that remain undetected due to occlusion are predicted and generated virtually. Experimental results show that staircases are detected accurately and predicted successfully.
Sun, Qian,Zhu, Lei,Meng, Ze-Da,Ullah, Kefayat,Ye, Shu,Oh, Won-Chun The Korean Ceramic Society 2013 한국세라믹학회지 Vol.50 No.4
ACF and ZnO modified $TiO_2$ composite materials (ZnO-ACF/$TiO_2$) were prepared by a sol-gel method. The composites were characterized by X-ray diffraction (XRD), energy dispersive X-ray (EDX) analysis and scanning electron microscope (SEM) analysis. A methyl orange (MO) solution under visible light irradiation was used to determine the photocatalytic activity. The degradation of the MO was determined using UV spectrophotometers. An increase in the photocatalytic activity was observed and attributed to an increase of the photo-absorption effect by the ZnO and the cooperative effect of the ACF.
{Poster Presentation} P46 : Angiotropic Metastatic Malignant Melanoma of Canine Mammary Gland Tumor
( Sun Hee Do ),( Won Ll Jeong ),( Sang Joon Park ),( Jae Yong Chung ),( Suk Hwan Lee ),( Young Ha Lee ),( Seo Jin Bak ),( Hee Joo Kim ),( Mi Na Seo ),( Mi Ran Ki ),( Won Seok Oh ),( Se Ll Park ),( Tae 한국수의병리학회 2005 한국수의병리학회 국제심포지움자료집 Vol.2005 No.-
Oh, Jin Young,Lee, Ji Hoon,Han, Sun Woong,Chae, Soo Sang,Bae, Eun Jin,Kang, Young Hun,Choi, Won Jin,Cho, Song Yun,Lee, Jeong-O,Baik, Hong Koo,Lee, Tae Il The Royal Society of Chemistry 2016 ENERGY AND ENVIRONMENTAL SCIENCE Vol.9 No.5
<P>To utilize human heat energy as a permanent power source, we demonstrate, for the first time, an intrinsically highly foldable and stretchable thermoelectric generator that is based upon chemically exfoliated 1T-transition metal dichalcogenide (TMDC) nanosheets (NSs) for self-powered wearable electronics. The power factors of WS2 (n-type) and NbSe2 (p-type) NS films were evaluated to be 5-7 mu K-2 m(-1) and 26-34 mu W K-2 m(-1), respectively, near room temperature. With these films, parallel-connected thermoelectric generators that were fabricated were able to constantly produce up to 38 nW of output power at D60 K. The thermoelectric device stably sustained its performance, even after 100 bending cycles and after 100 stretching cycles (50% strain). By direct observation, we found that the film is highly stretched by partial tearing and folding but still maintains an electrical percolation pathway. The morphology then is quickly recovered by a plug-in contact between the torn parts as the external strain is released. Finally, we demonstrate the electric power generation from a prototype wearable thermoelectric generator that was woven into a wristband fitted on a real human body.</P>
Oh, Sun Kyung,Kim, Hee Sun,Ahn, Hee Jin,Seol, Hye Won,Kim, Yoon Young,Park, Yong Bin,Yoon, Chul Jong,Kim, Dong-Wook,Kim, Seok Hyun,Moon, Shin Yong Wiley (John WileySons) 2005 Stem cells Vol.23 No.2
<P>Here we report the derivation and characterization of new human embryonic stem cell (hESC) lines, SNUhES1, SNUhES2, and SNUhES3. These cells, established from the inner cell mass using an STO feeder layer, satisfy the criteria that characterize pluripotent hESCs: The cell lines express high levels of alkaline phosphatase, cell surface markers (such as SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81), transcription factor Oct-4, and telomerase. When grafted into severe combined immunodeficient mice after prolonged proliferation, these cells maintained the developmental potentials to form derivatives of all three embryonic germ layers. The cell lines have normal karyotypes and distinct identities, revealed from DNA fingerprinting. Interestingly, analysis by electron microscopy clearly shows the morphological difference between undifferentiated and differentiated hESCs. Undifferentiated hESCs have a high ratio of nucleus to cytoplasm, prominent nucleoli, indistinct cell membranes, free ribosomes, and small mitochondria with a few crista, whereas differentiated cells retain irregular nuclear morphology, desmosomes, extensive cytoplasmic membranes, tonofilaments, and highly developed cellular organelles such as Golgi complex with secretory vesicles, endoplasmic reticulum studded with ribosomes, and large mitochondria. Existence of desmosomes and tonofilaments indicates that these cells differentiated into epithelial cells. When in vitro differentiation potentials of these cell lines into cardiomyocytes were examined, SNUhES3 was found to differentiate into cardiomyocytes most effectively.</P>